Prevalence of Sarcopenia and Its Effect on Postoperative Complications in Patients with Crohn’s Disease
Background and Aims. Sarcopenia is a prognostic factor of outcomes for various diseases, but reports on sarcopenia in patients with Crohn’s disease (CD) are few. We aim to determine the prevalence of sarcopenia and assess the role of sarcopenia in postoperative complications in patients with CD at a...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/3267201 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850170108634202112 |
|---|---|
| author | Chen Zhang Dingye Yu Liwen Hong Tianyu Zhang Hua Liu Rong Fan Lei Wang Jie Zhong Zhengting Wang |
| author_facet | Chen Zhang Dingye Yu Liwen Hong Tianyu Zhang Hua Liu Rong Fan Lei Wang Jie Zhong Zhengting Wang |
| author_sort | Chen Zhang |
| collection | DOAJ |
| description | Background and Aims. Sarcopenia is a prognostic factor of outcomes for various diseases, but reports on sarcopenia in patients with Crohn’s disease (CD) are few. We aim to determine the prevalence of sarcopenia and assess the role of sarcopenia in postoperative complications in patients with CD at a tertiary referral center. Methods. Patients who underwent intestinal surgery for CD from January 2013 to October 2019 were retrospectively enrolled. The L3 skeletal muscle mass index (SMI) was used to identify sarcopenia. Demographic data, preoperative laboratory data, surgical details, and hospital outcomes were recorded. The factors associated with postoperative complications were evaluated through univariate and multivariate analyses. Results. One hundred and twenty-four patients were enrolled. Thirty-four of them (27.4%), including 11 males, were diagnosed with sarcopenia. Compared with patients without sarcopenia, sarcopenic patients had a significantly lower BMI (P<0.001); lower preoperative serum albumin (P=0.006), prealbumin (P=0.030), and hemoglobin levels (P<0.001); longer hospital stay (34.4±26.8 days vs. 22.8±15.6 days, P=0.003); and more occurrences of complications (41.2% vs. 23.3%, P=0.049). The overall incidence of postoperative complications was 28.2%. Infection (51.4%) and intestinal fistula (22.9%) were the most common among such complications. Through the multivariate analysis, sarcopenia was identified as an independent risk factor for major postoperative complications (odds ratio=3.974, 95%CI=1.171–13.489, P=0.027). Conclusion. Sarcopenia is common in patients with CD requiring bowel resection, and it significantly increases the risk of major postoperative complications. |
| format | Article |
| id | doaj-art-a3224129c9d44cf3a363b06d8fe60bb5 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-a3224129c9d44cf3a363b06d8fe60bb52025-08-20T02:20:33ZengWileyGastroenterology Research and Practice1687-61211687-630X2021-01-01202110.1155/2021/32672013267201Prevalence of Sarcopenia and Its Effect on Postoperative Complications in Patients with Crohn’s DiseaseChen Zhang0Dingye Yu1Liwen Hong2Tianyu Zhang3Hua Liu4Rong Fan5Lei Wang6Jie Zhong7Zhengting Wang8Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Gastrointestinal Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaBackground and Aims. Sarcopenia is a prognostic factor of outcomes for various diseases, but reports on sarcopenia in patients with Crohn’s disease (CD) are few. We aim to determine the prevalence of sarcopenia and assess the role of sarcopenia in postoperative complications in patients with CD at a tertiary referral center. Methods. Patients who underwent intestinal surgery for CD from January 2013 to October 2019 were retrospectively enrolled. The L3 skeletal muscle mass index (SMI) was used to identify sarcopenia. Demographic data, preoperative laboratory data, surgical details, and hospital outcomes were recorded. The factors associated with postoperative complications were evaluated through univariate and multivariate analyses. Results. One hundred and twenty-four patients were enrolled. Thirty-four of them (27.4%), including 11 males, were diagnosed with sarcopenia. Compared with patients without sarcopenia, sarcopenic patients had a significantly lower BMI (P<0.001); lower preoperative serum albumin (P=0.006), prealbumin (P=0.030), and hemoglobin levels (P<0.001); longer hospital stay (34.4±26.8 days vs. 22.8±15.6 days, P=0.003); and more occurrences of complications (41.2% vs. 23.3%, P=0.049). The overall incidence of postoperative complications was 28.2%. Infection (51.4%) and intestinal fistula (22.9%) were the most common among such complications. Through the multivariate analysis, sarcopenia was identified as an independent risk factor for major postoperative complications (odds ratio=3.974, 95%CI=1.171–13.489, P=0.027). Conclusion. Sarcopenia is common in patients with CD requiring bowel resection, and it significantly increases the risk of major postoperative complications.http://dx.doi.org/10.1155/2021/3267201 |
| spellingShingle | Chen Zhang Dingye Yu Liwen Hong Tianyu Zhang Hua Liu Rong Fan Lei Wang Jie Zhong Zhengting Wang Prevalence of Sarcopenia and Its Effect on Postoperative Complications in Patients with Crohn’s Disease Gastroenterology Research and Practice |
| title | Prevalence of Sarcopenia and Its Effect on Postoperative Complications in Patients with Crohn’s Disease |
| title_full | Prevalence of Sarcopenia and Its Effect on Postoperative Complications in Patients with Crohn’s Disease |
| title_fullStr | Prevalence of Sarcopenia and Its Effect on Postoperative Complications in Patients with Crohn’s Disease |
| title_full_unstemmed | Prevalence of Sarcopenia and Its Effect on Postoperative Complications in Patients with Crohn’s Disease |
| title_short | Prevalence of Sarcopenia and Its Effect on Postoperative Complications in Patients with Crohn’s Disease |
| title_sort | prevalence of sarcopenia and its effect on postoperative complications in patients with crohn s disease |
| url | http://dx.doi.org/10.1155/2021/3267201 |
| work_keys_str_mv | AT chenzhang prevalenceofsarcopeniaanditseffectonpostoperativecomplicationsinpatientswithcrohnsdisease AT dingyeyu prevalenceofsarcopeniaanditseffectonpostoperativecomplicationsinpatientswithcrohnsdisease AT liwenhong prevalenceofsarcopeniaanditseffectonpostoperativecomplicationsinpatientswithcrohnsdisease AT tianyuzhang prevalenceofsarcopeniaanditseffectonpostoperativecomplicationsinpatientswithcrohnsdisease AT hualiu prevalenceofsarcopeniaanditseffectonpostoperativecomplicationsinpatientswithcrohnsdisease AT rongfan prevalenceofsarcopeniaanditseffectonpostoperativecomplicationsinpatientswithcrohnsdisease AT leiwang prevalenceofsarcopeniaanditseffectonpostoperativecomplicationsinpatientswithcrohnsdisease AT jiezhong prevalenceofsarcopeniaanditseffectonpostoperativecomplicationsinpatientswithcrohnsdisease AT zhengtingwang prevalenceofsarcopeniaanditseffectonpostoperativecomplicationsinpatientswithcrohnsdisease |