Bidirectional Interaction Between Chronic Kidney Disease and Porphyromonas gingivalis Infection Drives Inflammation and Immune Dysfunction

Bidirectional Interaction Between Chronic Kidney Disease and Porphyromonas gingivalis Infection Drives Inflammation and Immune Dysfunction

Results and Conclusion: Our findings demonstrate that uremic toxins, such as indoxyl sulfate (IS), alter responses of macrophages and lymphocytes to P. gingivalis. In vivo, CKD significantly enhanced P. gingivalis survival and infection-induced alveolar bone loss. The increased distribution of patho...

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Bibliographic Details
Main Authors: Karina Adamowicz, Andrea Sofia Lima Ribeiro, Anna Golda, Marta Wadowska, Jan Potempa, Christoph Schmaderer, Hans-Joachim Anders, Joanna Koziel, Maciej Lech
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/jimr/8355738
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