Evaluation of acoustic-thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapy
Purpose To evaluate numerical simulations of focused ultrasound (FUS) with a rabbit model, comparing simulated heating characteristics with magnetic resonance temperature imaging (MRTI) data collected during in vivo treatment.Methods A rabbit model was treated with FUS sonications in the biceps femo...
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| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2023.2301489 |
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| author | Nicholas Richards Douglas Christensen Joshua Hillyard Michelle Kline Sara Johnson Henrik Odéen Allison Payne |
| author_facet | Nicholas Richards Douglas Christensen Joshua Hillyard Michelle Kline Sara Johnson Henrik Odéen Allison Payne |
| author_sort | Nicholas Richards |
| collection | DOAJ |
| description | Purpose To evaluate numerical simulations of focused ultrasound (FUS) with a rabbit model, comparing simulated heating characteristics with magnetic resonance temperature imaging (MRTI) data collected during in vivo treatment.Methods A rabbit model was treated with FUS sonications in the biceps femoris with 3D MRTI collected. Acoustic and thermal properties of the rabbit muscle were determined experimentally. Numerical models of the rabbits were created, and tissue-type-specific properties were assigned. FUS simulations were performed using both the hybrid angular spectrum (HAS) method and k-Wave. Simulated power deposition patterns were converted to temperature maps using a Pennes’ bioheat equation-based thermal solver. Agreement of pressure between the simulation techniques and temperature between the simulation and experimental heating was evaluated. Contributions of scattering and absorption attenuation were considered.Results Simulated peak pressures derived using the HAS method exceeded the simulated peak pressures from k-Wave by 1.6 ± 2.7%. The location and FWHM of the peak pressure calculated from HAS and k-Wave showed good agreement. When muscle acoustic absorption value in the simulations was adjusted to approximately 54% of the measured attenuation, the average root-mean-squared error between simulated and experimental spatial-average temperature profiles was 0.046 ± 0.019 °C/W. Mean distance between simulated and experimental COTMs was 3.25 ± 1.37 mm. Transverse FWHMs of simulated sonications were smaller than in in vivo sonications. Longitudinal FWHMs were similar.Conclusions Presented results demonstrate agreement between HAS and k-Wave simulations and that FUS simulations can accurately predict focal position and heating for in vivo applications in soft tissue. |
| format | Article |
| id | doaj-art-a314a49768684b16ba792d2cd07e6cde |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-a314a49768684b16ba792d2cd07e6cde2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2023.2301489Evaluation of acoustic-thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapyNicholas Richards0Douglas Christensen1Joshua Hillyard2Michelle Kline3Sara Johnson4Henrik Odéen5Allison Payne6Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USADepartment of Biomedical Engineering, University of Utah, Salt Lake City, UT, USADepartment of Biomedical Engineering, University of Utah, Salt Lake City, UT, USADepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USADepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USADepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USADepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USAPurpose To evaluate numerical simulations of focused ultrasound (FUS) with a rabbit model, comparing simulated heating characteristics with magnetic resonance temperature imaging (MRTI) data collected during in vivo treatment.Methods A rabbit model was treated with FUS sonications in the biceps femoris with 3D MRTI collected. Acoustic and thermal properties of the rabbit muscle were determined experimentally. Numerical models of the rabbits were created, and tissue-type-specific properties were assigned. FUS simulations were performed using both the hybrid angular spectrum (HAS) method and k-Wave. Simulated power deposition patterns were converted to temperature maps using a Pennes’ bioheat equation-based thermal solver. Agreement of pressure between the simulation techniques and temperature between the simulation and experimental heating was evaluated. Contributions of scattering and absorption attenuation were considered.Results Simulated peak pressures derived using the HAS method exceeded the simulated peak pressures from k-Wave by 1.6 ± 2.7%. The location and FWHM of the peak pressure calculated from HAS and k-Wave showed good agreement. When muscle acoustic absorption value in the simulations was adjusted to approximately 54% of the measured attenuation, the average root-mean-squared error between simulated and experimental spatial-average temperature profiles was 0.046 ± 0.019 °C/W. Mean distance between simulated and experimental COTMs was 3.25 ± 1.37 mm. Transverse FWHMs of simulated sonications were smaller than in in vivo sonications. Longitudinal FWHMs were similar.Conclusions Presented results demonstrate agreement between HAS and k-Wave simulations and that FUS simulations can accurately predict focal position and heating for in vivo applications in soft tissue.https://www.tandfonline.com/doi/10.1080/02656736.2023.2301489Acoustic modelinghigh-intensity focused ultrasound |
| spellingShingle | Nicholas Richards Douglas Christensen Joshua Hillyard Michelle Kline Sara Johnson Henrik Odéen Allison Payne Evaluation of acoustic-thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapy International Journal of Hyperthermia Acoustic modeling high-intensity focused ultrasound |
| title | Evaluation of acoustic-thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapy |
| title_full | Evaluation of acoustic-thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapy |
| title_fullStr | Evaluation of acoustic-thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapy |
| title_full_unstemmed | Evaluation of acoustic-thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapy |
| title_short | Evaluation of acoustic-thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapy |
| title_sort | evaluation of acoustic thermal simulations of in vivo magnetic resonance guided focused ultrasound ablative therapy |
| topic | Acoustic modeling high-intensity focused ultrasound |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2023.2301489 |
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