Overview of the cellular and immune mechanisms involved in acute pancreatitis: In search of new prognosis biomarkers
Acute pancreatitis (AP) is an acute-onset gastrointestinal disease characterized by a significant inflammation of the pancreas. Most of the time, AP does not leave substantial changes in the pancreas after the resolution of the symptoms but the severe forms are associated with local or systemic comp...
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Cambridge University Press
2025-01-01
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| Series: | Expert Reviews in Molecular Medicine |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S1462399424000401/type/journal_article |
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| author | Alexandra Mititelu Alina Grama Marius-Cosmin Colceriu Tudor L. Pop |
| author_facet | Alexandra Mititelu Alina Grama Marius-Cosmin Colceriu Tudor L. Pop |
| author_sort | Alexandra Mititelu |
| collection | DOAJ |
| description | Acute pancreatitis (AP) is an acute-onset gastrointestinal disease characterized by a significant inflammation of the pancreas. Most of the time, AP does not leave substantial changes in the pancreas after the resolution of the symptoms but the severe forms are associated with local or systemic complications. The pathogenesis of AP has long been investigated and, lately, the importance of intracellular mechanisms and the immune system has been described. The initial modifications in AP take place in the acinar cell. There are multiple mechanisms by which cellular homeostasis is impaired, one of the most important being calcium overload. Necrotic pancreatic cells initiate the inflammatory response by secreting inflammatory mediators and attracting immune cells. From this point on, the inflammation is sustained by the involvement of innate and adaptive immune systems. Multiple studies have demonstrated the importance of the first 48 h for identifying patients at risk for developing severe forms. For this reason, there is a need to find new, easy-to-use and reliable markers for accurate predictions of these forms. This review provides an overview of the main pathogenetic mechanisms involved in AP development and the most promising biomarkers for severity stratification. |
| format | Article |
| id | doaj-art-a3130a5d528747beab257c9e85d47091 |
| institution | Kabale University |
| issn | 1462-3994 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Expert Reviews in Molecular Medicine |
| spelling | doaj-art-a3130a5d528747beab257c9e85d470912025-08-20T12:57:28ZengCambridge University PressExpert Reviews in Molecular Medicine1462-39942025-01-012710.1017/erm.2024.40Overview of the cellular and immune mechanisms involved in acute pancreatitis: In search of new prognosis biomarkersAlexandra Mititelu0https://orcid.org/0000-0002-0955-4486Alina Grama1https://orcid.org/0000-0001-7022-6345Marius-Cosmin Colceriu2https://orcid.org/0009-0001-8023-2631Tudor L. Pop3https://orcid.org/0000-0002-4931-12192nd Pediatric Discipline, Department of Mother and Child, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania2nd Pediatric Discipline, Department of Mother and Child, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania 2nd Pediatric Clinic, Emergency Clinical Hospital for Children, Cluj-Napoca, Romania2nd Pediatric Discipline, Department of Mother and Child, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania2nd Pediatric Discipline, Department of Mother and Child, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania 2nd Pediatric Clinic, Emergency Clinical Hospital for Children, Cluj-Napoca, RomaniaAcute pancreatitis (AP) is an acute-onset gastrointestinal disease characterized by a significant inflammation of the pancreas. Most of the time, AP does not leave substantial changes in the pancreas after the resolution of the symptoms but the severe forms are associated with local or systemic complications. The pathogenesis of AP has long been investigated and, lately, the importance of intracellular mechanisms and the immune system has been described. The initial modifications in AP take place in the acinar cell. There are multiple mechanisms by which cellular homeostasis is impaired, one of the most important being calcium overload. Necrotic pancreatic cells initiate the inflammatory response by secreting inflammatory mediators and attracting immune cells. From this point on, the inflammation is sustained by the involvement of innate and adaptive immune systems. Multiple studies have demonstrated the importance of the first 48 h for identifying patients at risk for developing severe forms. For this reason, there is a need to find new, easy-to-use and reliable markers for accurate predictions of these forms. This review provides an overview of the main pathogenetic mechanisms involved in AP development and the most promising biomarkers for severity stratification.https://www.cambridge.org/core/product/identifier/S1462399424000401/type/journal_articleacute pancreatitisbiomarkersimmune systempathogenesisprognosticseverity |
| spellingShingle | Alexandra Mititelu Alina Grama Marius-Cosmin Colceriu Tudor L. Pop Overview of the cellular and immune mechanisms involved in acute pancreatitis: In search of new prognosis biomarkers Expert Reviews in Molecular Medicine acute pancreatitis biomarkers immune system pathogenesis prognostic severity |
| title | Overview of the cellular and immune mechanisms involved in acute pancreatitis: In search of new prognosis biomarkers |
| title_full | Overview of the cellular and immune mechanisms involved in acute pancreatitis: In search of new prognosis biomarkers |
| title_fullStr | Overview of the cellular and immune mechanisms involved in acute pancreatitis: In search of new prognosis biomarkers |
| title_full_unstemmed | Overview of the cellular and immune mechanisms involved in acute pancreatitis: In search of new prognosis biomarkers |
| title_short | Overview of the cellular and immune mechanisms involved in acute pancreatitis: In search of new prognosis biomarkers |
| title_sort | overview of the cellular and immune mechanisms involved in acute pancreatitis in search of new prognosis biomarkers |
| topic | acute pancreatitis biomarkers immune system pathogenesis prognostic severity |
| url | https://www.cambridge.org/core/product/identifier/S1462399424000401/type/journal_article |
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