Immunohistochemical subtypes and their relationship with the clinicopathological and histological aspects of breast cancer
<strong>Background:</strong> The prognosis and therapy of breast cancer (BC) is closely related to the histopathological characteristics of the patient. These allow to establish prognostic groups, as support in the decision of effective individual treatments. However, the existing inform...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Spanish |
| Published: |
Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2022-05-01
|
| Series: | Medisur |
| Subjects: | |
| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/5255 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832576916512571392 |
|---|---|
| author | Lourdes González-Longoria Boada Secundino González Pardo Francisco López Muñoz |
| author_facet | Lourdes González-Longoria Boada Secundino González Pardo Francisco López Muñoz |
| author_sort | Lourdes González-Longoria Boada |
| collection | DOAJ |
| description | <strong>Background:</strong> The prognosis and therapy of breast cancer (BC) is closely related to the histopathological characteristics of the patient. These allow to establish prognostic groups, as support in the decision of effective individual treatments. However, the existing information is limited on the relationship between these aspects and the immunohistochemical subtypes (IHC) of breast cancer in Latin American countries. <br /><strong>Objective:</strong> To determine the relationship between the clinical-pathological and histological characteristics with the IHC subtypes of BC in Ecuadorian patients. <br /><strong>Methods:</strong> An observational of the cross-sectional study was carried out in Ecuadorian patients treated at the Abel Gilbert Pontón Hospital between January 2014 and December 2017. 199 patients with a histopathological diagnosis of BC were included. Clinicopathological variables were analyzed: age, tumor size and lymph node status; histological: type and histological grade.<br /><strong>Results:</strong> The mean age of the patients was 56,77 ± 11,96 years. Lymph node metastases were observed in most cases (63,3%). The mean tumor size was 3,88 ± 1,61 cm. More than half of the cases (56,8%) presented a moderately differentiated histological grade. The predominant molecular subtype was Luminal A neoplasia (53,8%). The analysis showed a significant association (p <0, 0001) between IHC subtypes and the clinicopathological and histological characteristics of BC. <br /><strong>Conclusions:</strong> Breast neoplasia in Ecuadorian patients is diagnosed in advanced stages. The study emphasizes the need to introduce IHC receptor tests into clinical practice to help determine the biology of breast cancer, improve the effect on therapy and the patient's prognosis.<br /><br /> |
| format | Article |
| id | doaj-art-a30f0809ca4f4ed6bcbf985d6f4ef629 |
| institution | Kabale University |
| issn | 1727-897X |
| language | Spanish |
| publishDate | 2022-05-01 |
| publisher | Centro Provincial de Información de Ciencias Médicas. Cienfuegos |
| record_format | Article |
| series | Medisur |
| spelling | doaj-art-a30f0809ca4f4ed6bcbf985d6f4ef6292025-01-30T21:28:58ZspaCentro Provincial de Información de Ciencias Médicas. CienfuegosMedisur1727-897X2022-05-012034784862142Immunohistochemical subtypes and their relationship with the clinicopathological and histological aspects of breast cancerLourdes González-Longoria Boada0Secundino González Pardo1Francisco López Muñoz2Facultad de Salud Pública. Universidad Camilo José Cela. Madrid. España.Facultad de Ciencias de la Salud. Universidad Técnica del Norte. Ecuador.Facultad de Salud Pública. Universidad Camilo José Cela. Madrid. España.<strong>Background:</strong> The prognosis and therapy of breast cancer (BC) is closely related to the histopathological characteristics of the patient. These allow to establish prognostic groups, as support in the decision of effective individual treatments. However, the existing information is limited on the relationship between these aspects and the immunohistochemical subtypes (IHC) of breast cancer in Latin American countries. <br /><strong>Objective:</strong> To determine the relationship between the clinical-pathological and histological characteristics with the IHC subtypes of BC in Ecuadorian patients. <br /><strong>Methods:</strong> An observational of the cross-sectional study was carried out in Ecuadorian patients treated at the Abel Gilbert Pontón Hospital between January 2014 and December 2017. 199 patients with a histopathological diagnosis of BC were included. Clinicopathological variables were analyzed: age, tumor size and lymph node status; histological: type and histological grade.<br /><strong>Results:</strong> The mean age of the patients was 56,77 ± 11,96 years. Lymph node metastases were observed in most cases (63,3%). The mean tumor size was 3,88 ± 1,61 cm. More than half of the cases (56,8%) presented a moderately differentiated histological grade. The predominant molecular subtype was Luminal A neoplasia (53,8%). The analysis showed a significant association (p <0, 0001) between IHC subtypes and the clinicopathological and histological characteristics of BC. <br /><strong>Conclusions:</strong> Breast neoplasia in Ecuadorian patients is diagnosed in advanced stages. The study emphasizes the need to introduce IHC receptor tests into clinical practice to help determine the biology of breast cancer, improve the effect on therapy and the patient's prognosis.<br /><br />http://medisur.sld.cu/index.php/medisur/article/view/5255cáncer de mama, biomarcadores, inmunohistoquímicapronóstico |
| spellingShingle | Lourdes González-Longoria Boada Secundino González Pardo Francisco López Muñoz Immunohistochemical subtypes and their relationship with the clinicopathological and histological aspects of breast cancer Medisur cáncer de mama, biomarcadores, inmunohistoquímica pronóstico |
| title | Immunohistochemical subtypes and their relationship with the clinicopathological and histological aspects of breast cancer |
| title_full | Immunohistochemical subtypes and their relationship with the clinicopathological and histological aspects of breast cancer |
| title_fullStr | Immunohistochemical subtypes and their relationship with the clinicopathological and histological aspects of breast cancer |
| title_full_unstemmed | Immunohistochemical subtypes and their relationship with the clinicopathological and histological aspects of breast cancer |
| title_short | Immunohistochemical subtypes and their relationship with the clinicopathological and histological aspects of breast cancer |
| title_sort | immunohistochemical subtypes and their relationship with the clinicopathological and histological aspects of breast cancer |
| topic | cáncer de mama, biomarcadores, inmunohistoquímica pronóstico |
| url | http://medisur.sld.cu/index.php/medisur/article/view/5255 |
| work_keys_str_mv | AT lourdesgonzalezlongoriaboada immunohistochemicalsubtypesandtheirrelationshipwiththeclinicopathologicalandhistologicalaspectsofbreastcancer AT secundinogonzalezpardo immunohistochemicalsubtypesandtheirrelationshipwiththeclinicopathologicalandhistologicalaspectsofbreastcancer AT franciscolopezmunoz immunohistochemicalsubtypesandtheirrelationshipwiththeclinicopathologicalandhistologicalaspectsofbreastcancer |