Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder
Brain tissue is particularly susceptible to oxidative stress (OS). Increased production of reactive oxygen species (ROS), reduced antioxidant systems, and decreased efficiency in repairing mechanisms have been linked to Alzheimer’s disease (AD). Postmortem studies in AD patients’ brains have shown o...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/624801 |
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| author | Mario Barbagallo Francesco Marotta Ligia J. Dominguez |
| author_facet | Mario Barbagallo Francesco Marotta Ligia J. Dominguez |
| author_sort | Mario Barbagallo |
| collection | DOAJ |
| description | Brain tissue is particularly susceptible to oxidative stress (OS). Increased production of reactive oxygen species (ROS), reduced antioxidant systems, and decreased efficiency in repairing mechanisms have been linked to Alzheimer’s disease (AD). Postmortem studies in AD patients’ brains have shown oxidative damage markers (i.e., lipid peroxidation, protein oxidative damage, and glycoxidation). Fermented papaya (FPP, a product of Carica papaya Linn fermentation with yeast) is a nutraceutical supplement with favorable effects on immunological, hematological, inflammatory, and OS parameters in chronic/degenerative diseases. We studied 40 patients (age 78.2 ± 1.1 years), 28 AD patients, and 12 controls. Urinary 8-OHdG was measured to assess OS. Twenty AD patients were supplemented with FPP (Immunage, 4.5 grams/day) for 6 months, while controls did not receive any treatment. At baseline, 8-OHdG was significantly higher in patients with AD versus controls (13.7 ± 1.61 ng/mL versus 1.6 ± 0.12 ng/mL, P<0.01). In AD patients FPP significantly decreased 8-OHdG (14.1 ± 1.7 ng/mL to 8.45 ± 1.1 ng/mL, P<0.01), with no significant changes in controls. AD is associated with increased OS, and FPP may be helpful to counteract excessive ROS in AD patients. |
| format | Article |
| id | doaj-art-a30d803e6dfe44c9afa30b0e2e867c7a |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a30d803e6dfe44c9afa30b0e2e867c7a2025-08-20T02:20:33ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/624801624801Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya PowderMario Barbagallo0Francesco Marotta1Ligia J. Dominguez2Geriatric Unit, Department DIBIMIS, University of Palermo, Via del Vespro, 129, 90127 Palermo, ItalyReGenera Research Group for Aging Intervention, Milano, ItalyGeriatric Unit, Department DIBIMIS, University of Palermo, Via del Vespro, 129, 90127 Palermo, ItalyBrain tissue is particularly susceptible to oxidative stress (OS). Increased production of reactive oxygen species (ROS), reduced antioxidant systems, and decreased efficiency in repairing mechanisms have been linked to Alzheimer’s disease (AD). Postmortem studies in AD patients’ brains have shown oxidative damage markers (i.e., lipid peroxidation, protein oxidative damage, and glycoxidation). Fermented papaya (FPP, a product of Carica papaya Linn fermentation with yeast) is a nutraceutical supplement with favorable effects on immunological, hematological, inflammatory, and OS parameters in chronic/degenerative diseases. We studied 40 patients (age 78.2 ± 1.1 years), 28 AD patients, and 12 controls. Urinary 8-OHdG was measured to assess OS. Twenty AD patients were supplemented with FPP (Immunage, 4.5 grams/day) for 6 months, while controls did not receive any treatment. At baseline, 8-OHdG was significantly higher in patients with AD versus controls (13.7 ± 1.61 ng/mL versus 1.6 ± 0.12 ng/mL, P<0.01). In AD patients FPP significantly decreased 8-OHdG (14.1 ± 1.7 ng/mL to 8.45 ± 1.1 ng/mL, P<0.01), with no significant changes in controls. AD is associated with increased OS, and FPP may be helpful to counteract excessive ROS in AD patients.http://dx.doi.org/10.1155/2015/624801 |
| spellingShingle | Mario Barbagallo Francesco Marotta Ligia J. Dominguez Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder Mediators of Inflammation |
| title | Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder |
| title_full | Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder |
| title_fullStr | Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder |
| title_full_unstemmed | Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder |
| title_short | Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder |
| title_sort | oxidative stress in patients with alzheimer s disease effect of extracts of fermented papaya powder |
| url | http://dx.doi.org/10.1155/2015/624801 |
| work_keys_str_mv | AT mariobarbagallo oxidativestressinpatientswithalzheimersdiseaseeffectofextractsoffermentedpapayapowder AT francescomarotta oxidativestressinpatientswithalzheimersdiseaseeffectofextractsoffermentedpapayapowder AT ligiajdominguez oxidativestressinpatientswithalzheimersdiseaseeffectofextractsoffermentedpapayapowder |