Amyloid‐β in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing
Abstract There is increasing evidence that common molecular pathways in neurons are closely linked with mitochondrial function and that mitochondrial dysfunction is connected to various forms of neurodegenerative diseases. For instance, mitochondria are involved in amyloid‐β (Aβ) deposition in Alzhe...
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| Format: | Article |
| Language: | English |
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Springer Nature
2016-01-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.201506050 |
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| _version_ | 1849235107511009280 |
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| author | Veronika Boczonadi Rita Horvath |
| author_facet | Veronika Boczonadi Rita Horvath |
| author_sort | Veronika Boczonadi |
| collection | DOAJ |
| description | Abstract There is increasing evidence that common molecular pathways in neurons are closely linked with mitochondrial function and that mitochondrial dysfunction is connected to various forms of neurodegenerative diseases. For instance, mitochondria are involved in amyloid‐β (Aβ) deposition in Alzheimer's disease, although the exact molecular pathways remain largely unknown. Brunetti et al (2015) in this issue of EMBO Molecular Medicine provide a novel link between Aβ accumulation and mitochondria. A pathogenic mutation in a Norwegian family in the mitochondrial metallopeptidase PITRM1 is found to underlie a novel mitochondrial neurodegenerative phenotype associated with Aβ accumulation. |
| format | Article |
| id | doaj-art-a30b22eb8e684a94b2a93e4cd96f1931 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-a30b22eb8e684a94b2a93e4cd96f19312025-08-20T04:02:55ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842016-01-018317317510.15252/emmm.201506050Amyloid‐β in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processingVeronika Boczonadi0Rita Horvath1Institute of Genetic Medicine, Wellcome Trust Centre for Mitochondrial Research, Newcastle UniversityInstitute of Genetic Medicine, Wellcome Trust Centre for Mitochondrial Research, Newcastle UniversityAbstract There is increasing evidence that common molecular pathways in neurons are closely linked with mitochondrial function and that mitochondrial dysfunction is connected to various forms of neurodegenerative diseases. For instance, mitochondria are involved in amyloid‐β (Aβ) deposition in Alzheimer's disease, although the exact molecular pathways remain largely unknown. Brunetti et al (2015) in this issue of EMBO Molecular Medicine provide a novel link between Aβ accumulation and mitochondria. A pathogenic mutation in a Norwegian family in the mitochondrial metallopeptidase PITRM1 is found to underlie a novel mitochondrial neurodegenerative phenotype associated with Aβ accumulation.https://doi.org/10.15252/emmm.201506050 |
| spellingShingle | Veronika Boczonadi Rita Horvath Amyloid‐β in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing EMBO Molecular Medicine |
| title | Amyloid‐β in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing |
| title_full | Amyloid‐β in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing |
| title_fullStr | Amyloid‐β in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing |
| title_full_unstemmed | Amyloid‐β in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing |
| title_short | Amyloid‐β in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing |
| title_sort | amyloid β in mitochondrial disease mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing |
| url | https://doi.org/10.15252/emmm.201506050 |
| work_keys_str_mv | AT veronikaboczonadi amyloidbinmitochondrialdiseasemutationinahumanmetallopeptidaselinksamyloidoticneurodegenerationwithmitochondrialprocessing AT ritahorvath amyloidbinmitochondrialdiseasemutationinahumanmetallopeptidaselinksamyloidoticneurodegenerationwithmitochondrialprocessing |