Role of the PI3K/AKT signaling pathway in the cellular response to Tumor Treating Fields (TTFields)

Role of the PI3K/AKT signaling pathway in the cellular response to Tumor Treating Fields (TTFields)

Abstract Tumor Treating Fields (TTFields) are electric fields that induce cancer cell death. Genomic analysis of glioblastoma tumors resected from TTFields-treated patients suggested a potential link between a reduced or absent response to TTFields and activating mutations in the phosphatidylinosito...

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Main Authors: Anat Klein-Goldberg, Tali Voloshin, Efrat Zemer Tov, Rom Paz, Lina Somri-Gannam, Alexandra Volodin, Lilach Koren, Lena Lifshitz, Aviv Meir, Ayelet Shabtay-Orbach, Roni Blatt, Shay Cahal, Catherine Tempel-Brami, Kerem Wainer-Katsir, Tal Kan, Bella Koltun, Boris Brant, Yiftah Barsheshet, Adi Haber, Moshe Giladi, Uri Weinberg, Yoram Palti
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07546-8
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