Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat
Afferent nerve signals were recorded from a peripheral cut end of the small nerve bundle of the hepatic branch of the vagus nerve in anesthetized rats. An injection of leptin (100 pg, 0.1 mL) into the portal vein facilitated the afferent activity. The response was dose dependent. Further, an intrave...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/516842 |
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| author | Akira Niijima |
| author_facet | Akira Niijima |
| author_sort | Akira Niijima |
| collection | DOAJ |
| description | Afferent nerve signals were recorded from a peripheral cut end of the small nerve bundle of the hepatic branch of the vagus nerve in anesthetized rats. An injection of leptin (100 pg, 0.1 mL) into the portal vein facilitated the afferent activity. The response was dose dependent. Further, an intravenous (IV) injection of leptin (1 ng, 0.1 mL) facilitated the efferent nerve activity of the sympathetic nerve to the adrenal gland and suppressed that of the celiac branch of the vagus nerve. In hepatic vagotomized rats, no change in efferent activity of the adrenal sympathetic nerve nor celiac branch of the vagus nerve was observed following iv administration of leptin. These observations suggest that leptin sensors in the hepatoportal region play a role in reflex modulation of autonomic outflow in relation to metabolic functions. |
| format | Article |
| id | doaj-art-a30764999c3a4d9ea61ec6c160c1f3cc |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-a30764999c3a4d9ea61ec6c160c1f3cc2025-02-03T06:13:46ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/516842516842Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the RatAkira Niijima0School of Medicine, Niigata University, Asahimachidori-1, Chuouku, Niigata 951-8510, JapanAfferent nerve signals were recorded from a peripheral cut end of the small nerve bundle of the hepatic branch of the vagus nerve in anesthetized rats. An injection of leptin (100 pg, 0.1 mL) into the portal vein facilitated the afferent activity. The response was dose dependent. Further, an intravenous (IV) injection of leptin (1 ng, 0.1 mL) facilitated the efferent nerve activity of the sympathetic nerve to the adrenal gland and suppressed that of the celiac branch of the vagus nerve. In hepatic vagotomized rats, no change in efferent activity of the adrenal sympathetic nerve nor celiac branch of the vagus nerve was observed following iv administration of leptin. These observations suggest that leptin sensors in the hepatoportal region play a role in reflex modulation of autonomic outflow in relation to metabolic functions.http://dx.doi.org/10.1155/2011/516842 |
| spellingShingle | Akira Niijima Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat Journal of Obesity |
| title | Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat |
| title_full | Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat |
| title_fullStr | Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat |
| title_full_unstemmed | Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat |
| title_short | Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat |
| title_sort | hepatoportal leptin sensors and their reflex effects on autonomic outflow in the rat |
| url | http://dx.doi.org/10.1155/2011/516842 |
| work_keys_str_mv | AT akiraniijima hepatoportalleptinsensorsandtheirreflexeffectsonautonomicoutflowintherat |