Unveiling ammonia-induced cell death: a new frontier in clear cell renal cell carcinoma prognosis

Unveiling ammonia-induced cell death: a new frontier in clear cell renal cell carcinoma prognosis

BackgroundClear cell renal cell carcinoma (KIRC) is the most aggressive renal carcinoma subtype of renal carcinoma, characterized by high mortality, early metastasis, and resistance to treatment. Ammonia-induced cell death (AICD) has recently been identified as a novel metabolic mechanism influencin...

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Bibliographic Details
Main Authors: Peize Yu, Qikai Zhong, Xinlei Wang, Yifang Liu, Qiang Liu, Yuqiang Zhang, Jiawei Lu, Yang Dong, Cong-hui Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
clear cell renal cell carcinoma
ammonia-induced cell death
prognostic risk model
ATP1A1
metabolic reprogramming
immune microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1636977/full
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