Pulmonary Hypertension in Women
Pulmonary arterial hypertension (PAH) is a rare devastating disease characterized by elevated pulmonary artery pressure and increased pulmonary vascular resistance. Females have a higher incidence of PAH, which is reflected globally across registries in the United States, Europe, and Asia. However,...
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| Format: | Article |
| Language: | English |
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Houston Methodist DeBakey Heart & Vascular Center
2024-03-01
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| Series: | Methodist DeBakey Cardiovascular Journal |
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| Online Access: | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1308 |
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| author | Eunwoo Park Zeenat Safdar |
| author_facet | Eunwoo Park Zeenat Safdar |
| author_sort | Eunwoo Park |
| collection | DOAJ |
| description | Pulmonary arterial hypertension (PAH) is a rare devastating disease characterized by elevated pulmonary artery pressure and increased pulmonary vascular resistance. Females have a higher incidence of PAH, which is reflected globally across registries in the United States, Europe, and Asia. However, despite female predominance, women had better outcomes compared with male patients, a finding that has been labeled the “estrogen paradox.” Special considerations should be given to women with PAH regarding sexual health, contraception, family planning, and treatment before, during, and after pregnancy. Pregnant women with PAH should be referred to a pulmonary hypertension care center; a multidisciplinary team approach is recommended, and Cesarean section is the preferred mode of delivery. While pregnancy outcomes have improved over the years with PAH-specific therapy, pregnancy portends a high-risk for those with PAH. Continued research is needed to tailor PAH treatment for women. |
| format | Article |
| id | doaj-art-a2f0ce50b40f48589077db11b4246038 |
| institution | OA Journals |
| issn | 1947-6108 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Houston Methodist DeBakey Heart & Vascular Center |
| record_format | Article |
| series | Methodist DeBakey Cardiovascular Journal |
| spelling | doaj-art-a2f0ce50b40f48589077db11b42460382025-08-20T02:22:16ZengHouston Methodist DeBakey Heart & Vascular CenterMethodist DeBakey Cardiovascular Journal1947-61082024-03-01202708010.14797/mdcvj.13081285Pulmonary Hypertension in WomenEunwoo Park0https://orcid.org/0009-0002-5016-5471Zeenat Safdar1https://orcid.org/0000-0002-8984-8205Houston Methodist Hospital, Houston, TexasHouston Methodist Lung Center, Houston Methodist Hospital, Houston, Texas; Weill Cornell College of Medicine, New York, New YorkPulmonary arterial hypertension (PAH) is a rare devastating disease characterized by elevated pulmonary artery pressure and increased pulmonary vascular resistance. Females have a higher incidence of PAH, which is reflected globally across registries in the United States, Europe, and Asia. However, despite female predominance, women had better outcomes compared with male patients, a finding that has been labeled the “estrogen paradox.” Special considerations should be given to women with PAH regarding sexual health, contraception, family planning, and treatment before, during, and after pregnancy. Pregnant women with PAH should be referred to a pulmonary hypertension care center; a multidisciplinary team approach is recommended, and Cesarean section is the preferred mode of delivery. While pregnancy outcomes have improved over the years with PAH-specific therapy, pregnancy portends a high-risk for those with PAH. Continued research is needed to tailor PAH treatment for women.https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1308pulmonary hypertensionpulmonary arterial hypertensionheart disease in womenestrogen paradox |
| spellingShingle | Eunwoo Park Zeenat Safdar Pulmonary Hypertension in Women Methodist DeBakey Cardiovascular Journal pulmonary hypertension pulmonary arterial hypertension heart disease in women estrogen paradox |
| title | Pulmonary Hypertension in Women |
| title_full | Pulmonary Hypertension in Women |
| title_fullStr | Pulmonary Hypertension in Women |
| title_full_unstemmed | Pulmonary Hypertension in Women |
| title_short | Pulmonary Hypertension in Women |
| title_sort | pulmonary hypertension in women |
| topic | pulmonary hypertension pulmonary arterial hypertension heart disease in women estrogen paradox |
| url | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1308 |
| work_keys_str_mv | AT eunwoopark pulmonaryhypertensioninwomen AT zeenatsafdar pulmonaryhypertensioninwomen |