Planned Abscopal Effect with Concurrent Pembrolizumab and Ablative Radiotherapy to Pulmonary Metastasis: A Case Report and Review of the Literature
Most abscopal effects are reported as sporadic and unpredictable events following radiotherapy at symptomatic sites. Herein, we report a case in which a planned abscopal effect was induced following deliberate radiotherapy and concurrent systemic immunotherapy. A 53-year-old man with a combined posi...
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MDPI AG
2024-12-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/31/12/573 |
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| author | Yu-Ting Lee Chien-Chin Chen Hsiya Chao Chih-Chia Chang Cheng-Yen Lee |
| author_facet | Yu-Ting Lee Chien-Chin Chen Hsiya Chao Chih-Chia Chang Cheng-Yen Lee |
| author_sort | Yu-Ting Lee |
| collection | DOAJ |
| description | Most abscopal effects are reported as sporadic and unpredictable events following radiotherapy at symptomatic sites. Herein, we report a case in which a planned abscopal effect was induced following deliberate radiotherapy and concurrent systemic immunotherapy. A 53-year-old man with a combined positive score ≥10 developed extensive metastatic bladder cancer after progressing on conventional chemotherapy. Extensive metastases were identified in his liver, lungs, and bones. He later had four cycles of single-agent pembrolizumab and planned hypofractionated radiotherapy at an ablative dose to selected metastatic lung tumors and developed complete remission of disease even when pembrolizumab was discontinued. This is a clear demonstration that the abscopal effect could be harnessed in a systematic manner with a combined positive score and aggressive local radiotherapy. |
| format | Article |
| id | doaj-art-a2ee3c96f3b64deabb88be3bea6f83ed |
| institution | OA Journals |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-a2ee3c96f3b64deabb88be3bea6f83ed2025-08-20T02:00:41ZengMDPI AGCurrent Oncology1198-00521718-77292024-12-0131127787779210.3390/curroncol31120573Planned Abscopal Effect with Concurrent Pembrolizumab and Ablative Radiotherapy to Pulmonary Metastasis: A Case Report and Review of the LiteratureYu-Ting Lee0Chien-Chin Chen1Hsiya Chao2Chih-Chia Chang3Cheng-Yen Lee4Division of Hematology and Oncology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, TaiwanDepartment of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 60002, TaiwanDepartment of Biomedical Engineering, Chung Yuan Christian University, Taoyuan 320314, TaiwanDepartment of Radiation Oncology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, TaiwanDepartment of Radiation Oncology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, TaiwanMost abscopal effects are reported as sporadic and unpredictable events following radiotherapy at symptomatic sites. Herein, we report a case in which a planned abscopal effect was induced following deliberate radiotherapy and concurrent systemic immunotherapy. A 53-year-old man with a combined positive score ≥10 developed extensive metastatic bladder cancer after progressing on conventional chemotherapy. Extensive metastases were identified in his liver, lungs, and bones. He later had four cycles of single-agent pembrolizumab and planned hypofractionated radiotherapy at an ablative dose to selected metastatic lung tumors and developed complete remission of disease even when pembrolizumab was discontinued. This is a clear demonstration that the abscopal effect could be harnessed in a systematic manner with a combined positive score and aggressive local radiotherapy.https://www.mdpi.com/1718-7729/31/12/573abscopal effectradiotherapyimmune check point inhibitorpembrolizumab |
| spellingShingle | Yu-Ting Lee Chien-Chin Chen Hsiya Chao Chih-Chia Chang Cheng-Yen Lee Planned Abscopal Effect with Concurrent Pembrolizumab and Ablative Radiotherapy to Pulmonary Metastasis: A Case Report and Review of the Literature Current Oncology abscopal effect radiotherapy immune check point inhibitor pembrolizumab |
| title | Planned Abscopal Effect with Concurrent Pembrolizumab and Ablative Radiotherapy to Pulmonary Metastasis: A Case Report and Review of the Literature |
| title_full | Planned Abscopal Effect with Concurrent Pembrolizumab and Ablative Radiotherapy to Pulmonary Metastasis: A Case Report and Review of the Literature |
| title_fullStr | Planned Abscopal Effect with Concurrent Pembrolizumab and Ablative Radiotherapy to Pulmonary Metastasis: A Case Report and Review of the Literature |
| title_full_unstemmed | Planned Abscopal Effect with Concurrent Pembrolizumab and Ablative Radiotherapy to Pulmonary Metastasis: A Case Report and Review of the Literature |
| title_short | Planned Abscopal Effect with Concurrent Pembrolizumab and Ablative Radiotherapy to Pulmonary Metastasis: A Case Report and Review of the Literature |
| title_sort | planned abscopal effect with concurrent pembrolizumab and ablative radiotherapy to pulmonary metastasis a case report and review of the literature |
| topic | abscopal effect radiotherapy immune check point inhibitor pembrolizumab |
| url | https://www.mdpi.com/1718-7729/31/12/573 |
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