Pregnancy-related intracranial venous sinus thrombosis secondary to cryptococcal meningoencephalitis: a case report and literature review
Abstract Background Cerebral venous sinus thrombosis (CVST), a serious cerebrovascular and neurological emergency, is common in pregnant individuals and accounts for approximately 0.5–1.0% of all cerebrovascular diseases. However, CVST with cryptococcal meningoencephalitis in immunocompetent pregnan...
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| Language: | English |
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BMC
2024-10-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-024-10054-3 |
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| author | Junbing He Yufu He Yuting Qin Lizhen Liu Mingwei Xu Qinghua Liu |
| author_facet | Junbing He Yufu He Yuting Qin Lizhen Liu Mingwei Xu Qinghua Liu |
| author_sort | Junbing He |
| collection | DOAJ |
| description | Abstract Background Cerebral venous sinus thrombosis (CVST), a serious cerebrovascular and neurological emergency, is common in pregnant individuals and accounts for approximately 0.5–1.0% of all cerebrovascular diseases. However, CVST with cryptococcal meningoencephalitis in immunocompetent pregnant patients is rare. Case presentation A 30-year-old woman who was 33 weeks pregnant presented with recurrent dizziness, headache, and vomiting as the main clinical manifestations, all of which were initially nonspecific. After assessment of the cerebrospinal fluid, skull computerized tomography, magnetic resonance imaging, and other laboratory and imaging examinations, the patient was diagnosed with secondary pregnancy-related CVST with cryptococcal meningoencephalitis. Despite receiving potent anticoagulant and antifungal treatment, the patient’s condition deteriorated, and the patient’s family opted to cease treatment. Conclusions We present a rare case of CVST with cryptococcal meningoencephalitis in an immunocompetent pregnant patient. The difficulty of diagnosing and treating secondary pregnancy-related CVST caused by cryptococcal meningoencephalitis, as well as the great challenges faced at present are highlighted. One crucial lesson from the present case is that when clinical and imaging signs are unusual for CVST during pregnancy, it is essential to account for the possibility of other central nervous system (CNS) diseases, such as CNS infections with Cryptococcus, which may cause CVST. |
| format | Article |
| id | doaj-art-a2ee152278a54ed2957ec15055fd85aa |
| institution | OA Journals |
| issn | 1471-2334 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-a2ee152278a54ed2957ec15055fd85aa2025-08-20T02:17:39ZengBMCBMC Infectious Diseases1471-23342024-10-012411610.1186/s12879-024-10054-3Pregnancy-related intracranial venous sinus thrombosis secondary to cryptococcal meningoencephalitis: a case report and literature reviewJunbing He0Yufu He1Yuting Qin2Lizhen Liu3Mingwei Xu4Qinghua Liu5Jieyang Medical Research Center, Jieyang People’s HospitalJieyang Medical Research Center, Jieyang People’s HospitalThe Intensive Care Unit, Affiliated Hospital of Guangdong Medical UniversityThe Intensive Care Unit, Affiliated Hospital of Guangdong Medical UniversityJieyang Medical Research Center, Jieyang People’s HospitalJieyang Medical Research Center, Jieyang People’s HospitalAbstract Background Cerebral venous sinus thrombosis (CVST), a serious cerebrovascular and neurological emergency, is common in pregnant individuals and accounts for approximately 0.5–1.0% of all cerebrovascular diseases. However, CVST with cryptococcal meningoencephalitis in immunocompetent pregnant patients is rare. Case presentation A 30-year-old woman who was 33 weeks pregnant presented with recurrent dizziness, headache, and vomiting as the main clinical manifestations, all of which were initially nonspecific. After assessment of the cerebrospinal fluid, skull computerized tomography, magnetic resonance imaging, and other laboratory and imaging examinations, the patient was diagnosed with secondary pregnancy-related CVST with cryptococcal meningoencephalitis. Despite receiving potent anticoagulant and antifungal treatment, the patient’s condition deteriorated, and the patient’s family opted to cease treatment. Conclusions We present a rare case of CVST with cryptococcal meningoencephalitis in an immunocompetent pregnant patient. The difficulty of diagnosing and treating secondary pregnancy-related CVST caused by cryptococcal meningoencephalitis, as well as the great challenges faced at present are highlighted. One crucial lesson from the present case is that when clinical and imaging signs are unusual for CVST during pregnancy, it is essential to account for the possibility of other central nervous system (CNS) diseases, such as CNS infections with Cryptococcus, which may cause CVST.https://doi.org/10.1186/s12879-024-10054-3Cerebral venous sinus thrombosisCryptococcal meningoencephalitisPregnancyMagnetic resonance venographyCase report |
| spellingShingle | Junbing He Yufu He Yuting Qin Lizhen Liu Mingwei Xu Qinghua Liu Pregnancy-related intracranial venous sinus thrombosis secondary to cryptococcal meningoencephalitis: a case report and literature review BMC Infectious Diseases Cerebral venous sinus thrombosis Cryptococcal meningoencephalitis Pregnancy Magnetic resonance venography Case report |
| title | Pregnancy-related intracranial venous sinus thrombosis secondary to cryptococcal meningoencephalitis: a case report and literature review |
| title_full | Pregnancy-related intracranial venous sinus thrombosis secondary to cryptococcal meningoencephalitis: a case report and literature review |
| title_fullStr | Pregnancy-related intracranial venous sinus thrombosis secondary to cryptococcal meningoencephalitis: a case report and literature review |
| title_full_unstemmed | Pregnancy-related intracranial venous sinus thrombosis secondary to cryptococcal meningoencephalitis: a case report and literature review |
| title_short | Pregnancy-related intracranial venous sinus thrombosis secondary to cryptococcal meningoencephalitis: a case report and literature review |
| title_sort | pregnancy related intracranial venous sinus thrombosis secondary to cryptococcal meningoencephalitis a case report and literature review |
| topic | Cerebral venous sinus thrombosis Cryptococcal meningoencephalitis Pregnancy Magnetic resonance venography Case report |
| url | https://doi.org/10.1186/s12879-024-10054-3 |
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