Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Background. The natural history of idiopathic pulmonary fibrosis (IPF) is very complex and unpredictable. Some patients will experience acute exacerbation (AE) and fatal outcomes. Methods. The study included 30 AE-IPF patients, 32 stable IPF (S-IPF) patients, and 12 healthy controls. We measured the...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/6940480 |
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| author | Mengshu Cao Jeffery J. Swigris Xin Wang Min Cao Yuying Qiu Mei Huang Yonglong Xiao Hourong Cai |
| author_facet | Mengshu Cao Jeffery J. Swigris Xin Wang Min Cao Yuying Qiu Mei Huang Yonglong Xiao Hourong Cai |
| author_sort | Mengshu Cao |
| collection | DOAJ |
| description | Background. The natural history of idiopathic pulmonary fibrosis (IPF) is very complex and unpredictable. Some patients will experience acute exacerbation (AE) and fatal outcomes. Methods. The study included 30 AE-IPF patients, 32 stable IPF (S-IPF) patients, and 12 healthy controls. We measured the plasma concentrations of leptin and KL-6. Simple correlation was used to assess associations between leptin and other variables. Plasma leptin levels were compared between AE-IPF and S-IPF subjects, decedents, and survivors. Kaplan-Meier curves were used to display survival and Cox proportional hazards regression was used to examine risk factors for survival. Results. In subjects with AE-IPF, plasma leptin was significantly greater than in subjects with S-IPF (p=0.0003) or healthy controls (p<0.0001). Plasma leptin was correlated with BMI, KL-6, LDH, CRP, and PaO2/FiO2 (p=0.007; p=0.005; p=0.003; p=0.033; and p=0.032, resp.). Plasma leptin was significantly greater in 33 decedents than in the 23 survivors (p=0.007). Multivariate Cox regression analysis showed leptin (>13.79 ng/mL) was an independent predictor of survival (p=0.004). Conclusions. Leptin could be a promising plasma biomarker of AE-IPF occurrence and predictor of survival in IPF patients. |
| format | Article |
| id | doaj-art-a2e9ffe3cad84c81912a5d48a80111f1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a2e9ffe3cad84c81912a5d48a80111f12025-08-20T03:38:18ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/69404806940480Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary FibrosisMengshu Cao0Jeffery J. Swigris1Xin Wang2Min Cao3Yuying Qiu4Mei Huang5Yonglong Xiao6Hourong Cai7Department of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, ChinaInterstitial Lung Disease Program, Department of Medicine, National Jewish Health, University of Colorado Denver, Denver, CO 80206, USADepartment of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, ChinaDepartment of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, ChinaDepartment of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, ChinaDepartment of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, ChinaDepartment of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, ChinaDepartment of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Nanjing University Medical School, Nanjing, Jiangsu 210008, ChinaBackground. The natural history of idiopathic pulmonary fibrosis (IPF) is very complex and unpredictable. Some patients will experience acute exacerbation (AE) and fatal outcomes. Methods. The study included 30 AE-IPF patients, 32 stable IPF (S-IPF) patients, and 12 healthy controls. We measured the plasma concentrations of leptin and KL-6. Simple correlation was used to assess associations between leptin and other variables. Plasma leptin levels were compared between AE-IPF and S-IPF subjects, decedents, and survivors. Kaplan-Meier curves were used to display survival and Cox proportional hazards regression was used to examine risk factors for survival. Results. In subjects with AE-IPF, plasma leptin was significantly greater than in subjects with S-IPF (p=0.0003) or healthy controls (p<0.0001). Plasma leptin was correlated with BMI, KL-6, LDH, CRP, and PaO2/FiO2 (p=0.007; p=0.005; p=0.003; p=0.033; and p=0.032, resp.). Plasma leptin was significantly greater in 33 decedents than in the 23 survivors (p=0.007). Multivariate Cox regression analysis showed leptin (>13.79 ng/mL) was an independent predictor of survival (p=0.004). Conclusions. Leptin could be a promising plasma biomarker of AE-IPF occurrence and predictor of survival in IPF patients.http://dx.doi.org/10.1155/2016/6940480 |
| spellingShingle | Mengshu Cao Jeffery J. Swigris Xin Wang Min Cao Yuying Qiu Mei Huang Yonglong Xiao Hourong Cai Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis Mediators of Inflammation |
| title | Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_full | Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_fullStr | Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_full_unstemmed | Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_short | Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_sort | plasma leptin is elevated in acute exacerbation of idiopathic pulmonary fibrosis |
| url | http://dx.doi.org/10.1155/2016/6940480 |
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