Functional and Anatomic Correlates of Two Frequently Observed Temporal Lobe Seizure-Onset Patterns
Intracranial depth electrode EEG records of 478 seizures, recorded in 68 patients undergoing diagnostic monitoring with depth electrodes, were evaluated to investigate the correlates of electrographic onset patterns in patients with temporal lobe seizures. The seizure onsets in 78% of these patients...
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2000.49 |
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| author | Ana Luisa Velascol Charles L. Wilson Thomas L. Babb Jerome Engel Jr |
| author_facet | Ana Luisa Velascol Charles L. Wilson Thomas L. Babb Jerome Engel Jr |
| author_sort | Ana Luisa Velascol |
| collection | DOAJ |
| description | Intracranial depth electrode EEG records
of 478 seizures, recorded in 68 patients
undergoing diagnostic monitoring with depth
electrodes, were evaluated to investigate the
correlates of electrographic onset patterns in
patients with temporal lobe seizures. The
seizure onsets in 78% of these patients were
identified as either hypersynchronous onsets,
beginning with low-frequency, high-amplitude
spikes, or low-voltage fast (LVF) onsets,
increasing in amplitude as the seizure
progressed. The number of patients (35)
having hypersynchronous seizure onsets was
nearly twice that of patients (18) having LVF
onsets. Three major differences were seen
among patients with the two seizure-onset
patterns. When compared with patients
having LVF onsets, patients with hypersynchronous
seizure onsets had a significantly
greater probability of having (1) focal rather
than regional seizure onsets (p<0.01), (2) seizures
spreading more slowly to the contralateral
mesial temporal lobe (p<0.003), and (3) cell
counts in resected hippocampal tissue showing
greater neuronal loss (p<0.001). The results
provide evidence that the most frequent electrographic abnormality associated with
mesial temporal seizures is local hypersynchrony,
a condition associated with major
neuronal-loss in the hippocampus. The results
also indicate that LVF seizure onsets more
frequently represent widely distributed discharges,
which interact with and spread more
rapidly to surrounding neocortical areas. |
| format | Article |
| id | doaj-art-a2e360942e5e47d4a93f02dadcf61f03 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-a2e360942e5e47d4a93f02dadcf61f032025-08-20T03:38:18ZengWileyNeural Plasticity2090-59041687-54432000-01-0171-2496310.1155/NP.2000.49Functional and Anatomic Correlates of Two Frequently Observed Temporal Lobe Seizure-Onset PatternsAna Luisa Velascol0Charles L. Wilson1Thomas L. Babb2Jerome Engel Jr3Medical Research Unit in Neurophysiology, National Medical Center, IMSS Mexico City, MexicoDepartment of Neurology, UCLA Center for the Health Sciences, Los Angeles, CA 90095, USADepartment of Neuroscienes NC-30 Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USADepartment of Neurology, UCLA Center for the Health Sciences, Los Angeles, CA 90095, USAIntracranial depth electrode EEG records of 478 seizures, recorded in 68 patients undergoing diagnostic monitoring with depth electrodes, were evaluated to investigate the correlates of electrographic onset patterns in patients with temporal lobe seizures. The seizure onsets in 78% of these patients were identified as either hypersynchronous onsets, beginning with low-frequency, high-amplitude spikes, or low-voltage fast (LVF) onsets, increasing in amplitude as the seizure progressed. The number of patients (35) having hypersynchronous seizure onsets was nearly twice that of patients (18) having LVF onsets. Three major differences were seen among patients with the two seizure-onset patterns. When compared with patients having LVF onsets, patients with hypersynchronous seizure onsets had a significantly greater probability of having (1) focal rather than regional seizure onsets (p<0.01), (2) seizures spreading more slowly to the contralateral mesial temporal lobe (p<0.003), and (3) cell counts in resected hippocampal tissue showing greater neuronal loss (p<0.001). The results provide evidence that the most frequent electrographic abnormality associated with mesial temporal seizures is local hypersynchrony, a condition associated with major neuronal-loss in the hippocampus. The results also indicate that LVF seizure onsets more frequently represent widely distributed discharges, which interact with and spread more rapidly to surrounding neocortical areas.http://dx.doi.org/10.1155/NP.2000.49 |
| spellingShingle | Ana Luisa Velascol Charles L. Wilson Thomas L. Babb Jerome Engel Jr Functional and Anatomic Correlates of Two Frequently Observed Temporal Lobe Seizure-Onset Patterns Neural Plasticity |
| title | Functional and Anatomic Correlates of Two Frequently Observed Temporal Lobe Seizure-Onset Patterns |
| title_full | Functional and Anatomic Correlates of Two Frequently Observed Temporal Lobe Seizure-Onset Patterns |
| title_fullStr | Functional and Anatomic Correlates of Two Frequently Observed Temporal Lobe Seizure-Onset Patterns |
| title_full_unstemmed | Functional and Anatomic Correlates of Two Frequently Observed Temporal Lobe Seizure-Onset Patterns |
| title_short | Functional and Anatomic Correlates of Two Frequently Observed Temporal Lobe Seizure-Onset Patterns |
| title_sort | functional and anatomic correlates of two frequently observed temporal lobe seizure onset patterns |
| url | http://dx.doi.org/10.1155/NP.2000.49 |
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