A translational review of hyperthermia biology
This review was written to be included in the Special Collection ‘Therapy Ultrasound: Medicine’s Swiss Army Knife?’ The purpose of this review is to provide basic presentation and interpretation of the fundamentals of hyperthermia biology, as it pertains to uses of therapeutic ultrasound. The fundam...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2447952 |
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| author | Mark W. Dewhirst |
| author_facet | Mark W. Dewhirst |
| author_sort | Mark W. Dewhirst |
| collection | DOAJ |
| description | This review was written to be included in the Special Collection ‘Therapy Ultrasound: Medicine’s Swiss Army Knife?’ The purpose of this review is to provide basic presentation and interpretation of the fundamentals of hyperthermia biology, as it pertains to uses of therapeutic ultrasound. The fundamentals are presented but in the setting of a translational interpretation and a view toward the future. Subjects that require future research and development are highlighted. The effects of hyperthermia are time and temperature dependent. Because intra-tumoral temperatures are non-uniform in tumors, one has to account for differential biologic effects in different parts of a tumor that occur simultaneously during and after hyperthermia. |
| format | Article |
| id | doaj-art-a2dff764c7d040acbea41570ed72ce09 |
| institution | OA Journals |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-a2dff764c7d040acbea41570ed72ce092025-08-20T02:35:39ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572025-12-0142110.1080/02656736.2024.2447952A translational review of hyperthermia biologyMark W. Dewhirst0Gustavo S. Montana Distinguished Professor Emeritus of Radiation Oncology, Duke University School of Medicine, Durham, NC, USAThis review was written to be included in the Special Collection ‘Therapy Ultrasound: Medicine’s Swiss Army Knife?’ The purpose of this review is to provide basic presentation and interpretation of the fundamentals of hyperthermia biology, as it pertains to uses of therapeutic ultrasound. The fundamentals are presented but in the setting of a translational interpretation and a view toward the future. Subjects that require future research and development are highlighted. The effects of hyperthermia are time and temperature dependent. Because intra-tumoral temperatures are non-uniform in tumors, one has to account for differential biologic effects in different parts of a tumor that occur simultaneously during and after hyperthermia.https://www.tandfonline.com/doi/10.1080/02656736.2024.2447952Hyperthermiathermal doseheat radiosensitizationtumor physiologyhypoxia |
| spellingShingle | Mark W. Dewhirst A translational review of hyperthermia biology International Journal of Hyperthermia Hyperthermia thermal dose heat radiosensitization tumor physiology hypoxia |
| title | A translational review of hyperthermia biology |
| title_full | A translational review of hyperthermia biology |
| title_fullStr | A translational review of hyperthermia biology |
| title_full_unstemmed | A translational review of hyperthermia biology |
| title_short | A translational review of hyperthermia biology |
| title_sort | translational review of hyperthermia biology |
| topic | Hyperthermia thermal dose heat radiosensitization tumor physiology hypoxia |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2447952 |
| work_keys_str_mv | AT markwdewhirst atranslationalreviewofhyperthermiabiology AT markwdewhirst translationalreviewofhyperthermiabiology |