Clinicopathological features of 71 patients with amyloidosis nephropathy
Objective To explore the clinicopathological features of patients with amyloidosis nephropathy to provide more rationales for clinical diagnosis and treatment.Methods From December 1997 to December 2019,clinicopathological data were retrospectively reviewed for 71 patients with amyloidosis diagnosed...
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Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | Zhao Xue Yu Che Wang Rong |
| author_facet | Zhao Xue Yu Che Wang Rong |
| author_sort | Zhao Xue |
| collection | DOAJ |
| description | Objective To explore the clinicopathological features of patients with amyloidosis nephropathy to provide more rationales for clinical diagnosis and treatment.Methods From December 1997 to December 2019,clinicopathological data were retrospectively reviewed for 71 patients with amyloidosis diagnosed by renal biopsy.Results The mean age was（57.2±9.9）years, 71.8% were aged 50 to 69 years and male-to-female ratio was 1.7∶1.The age and hemoglobin levels of males were higher than those of females.And the differences were statistically significant（P<0.05）.Hemoglobin and serum calcium in patients with higher serum creatinine（Scr）were significantly lower（P<0.05）while urea nitrogen, cystatin C,β<sub>2</sub>-microglobulin and uric acid were significantly higher than those with normal creatinine（P<0.05）.In a declining order, amyloid was deposited in glomerular mesangial area（96.2%）,capillary wall（28.3%）,interstitial small vessel wall（47.2%）,tubules（15.1%）,renal interstitium（5.7%）and subendothelium（1.9%）.In group of higher Scr, the rates of amyloid deposition were both higher in glomeruli（P=0.032）and tubular atrophy >10%（P=0.024）.However, no significant difference existed in clinicopathological parameters between patients with nephrotic-range proteinuria and non-nephrotic-range proteinuria.Conclusion Amyloidosis nephropathy occurs predominantly in middle-aged and elderly males.Glomerular damage is common in patients with amyloidosis nephropathy.And the degree of glomerular amyloidosis in renal tissue is associated with renal insufficiency rather than the level of urinary protein. |
| format | Article |
| id | doaj-art-a2dfc9cf920f4d669189f57d6fee96c8 |
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| issn | 1671-2390 |
| language | zho |
| publishDate | 2021-01-01 |
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| spelling | doaj-art-a2dfc9cf920f4d669189f57d6fee96c82025-08-20T02:16:13ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902021-01-012145546257905170Clinicopathological features of 71 patients with amyloidosis nephropathyZhao XueYu CheWang RongObjective To explore the clinicopathological features of patients with amyloidosis nephropathy to provide more rationales for clinical diagnosis and treatment.Methods From December 1997 to December 2019,clinicopathological data were retrospectively reviewed for 71 patients with amyloidosis diagnosed by renal biopsy.Results The mean age was（57.2±9.9）years, 71.8% were aged 50 to 69 years and male-to-female ratio was 1.7∶1.The age and hemoglobin levels of males were higher than those of females.And the differences were statistically significant（P<0.05）.Hemoglobin and serum calcium in patients with higher serum creatinine（Scr）were significantly lower（P<0.05）while urea nitrogen, cystatin C,β<sub>2</sub>-microglobulin and uric acid were significantly higher than those with normal creatinine（P<0.05）.In a declining order, amyloid was deposited in glomerular mesangial area（96.2%）,capillary wall（28.3%）,interstitial small vessel wall（47.2%）,tubules（15.1%）,renal interstitium（5.7%）and subendothelium（1.9%）.In group of higher Scr, the rates of amyloid deposition were both higher in glomeruli（P=0.032）and tubular atrophy >10%（P=0.024）.However, no significant difference existed in clinicopathological parameters between patients with nephrotic-range proteinuria and non-nephrotic-range proteinuria.Conclusion Amyloidosis nephropathy occurs predominantly in middle-aged and elderly males.Glomerular damage is common in patients with amyloidosis nephropathy.And the degree of glomerular amyloidosis in renal tissue is associated with renal insufficiency rather than the level of urinary protein.http://www.lcszb.com/thesisDetails?columnId=57905170&Fpath=home&index=0AmyloidosisPathology clinicalRenal insufficiency |
| spellingShingle | Zhao Xue Yu Che Wang Rong Clinicopathological features of 71 patients with amyloidosis nephropathy Linchuang shenzangbing zazhi Amyloidosis Pathology clinical Renal insufficiency |
| title | Clinicopathological features of 71 patients with amyloidosis nephropathy |
| title_full | Clinicopathological features of 71 patients with amyloidosis nephropathy |
| title_fullStr | Clinicopathological features of 71 patients with amyloidosis nephropathy |
| title_full_unstemmed | Clinicopathological features of 71 patients with amyloidosis nephropathy |
| title_short | Clinicopathological features of 71 patients with amyloidosis nephropathy |
| title_sort | clinicopathological features of 71 patients with amyloidosis nephropathy |
| topic | Amyloidosis Pathology clinical Renal insufficiency |
| url | http://www.lcszb.com/thesisDetails?columnId=57905170&Fpath=home&index=0 |
| work_keys_str_mv | AT zhaoxue clinicopathologicalfeaturesof71patientswithamyloidosisnephropathy AT yuche clinicopathologicalfeaturesof71patientswithamyloidosisnephropathy AT wangrong clinicopathologicalfeaturesof71patientswithamyloidosisnephropathy |