Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia

Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia

Background: In recent decades, targeted therapy using small molecule inhibitors (SMI) have been shown very promising results in the treatment of a variety of solid and hematopoietic malignancies. However, their exact mechanisms, especiallay on the evasion strategies of tumor cells from the host immu...

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Main Authors: Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biochemistry and Biophysics Reports
Subjects:
ALL
Ibrutinib
Venetoclax
Immune checkpoint molecules
TGF-β
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825001323
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