Evaluation of Some Immunological Parameters in Patients with COVID-19 in Mosul City, Iraq
Background: Coronavirus disease 2019 (COVID-19), also known as severe acute respiratory syndrome coronavirus 2, is a viral disease caused by a coronavirus involved in severe acute respiratory syndrome that causes mild, moderate, and severe respiratory system infections. World Health Organization has...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | https://doi.org/10.4103/MJBL.MJBL_36_23 |
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| author | Mohammed Fadhil Haddad Fawwaz Fadhil Ali Mohammed H. Sharif Alkatib Shihab A. Al-Bajari |
| author_facet | Mohammed Fadhil Haddad Fawwaz Fadhil Ali Mohammed H. Sharif Alkatib Shihab A. Al-Bajari |
| author_sort | Mohammed Fadhil Haddad |
| collection | DOAJ |
| description | Background: Coronavirus disease 2019 (COVID-19), also known as severe acute respiratory syndrome coronavirus 2, is a viral disease caused by a coronavirus involved in severe acute respiratory syndrome that causes mild, moderate, and severe respiratory system infections. World Health Organization has documented that COVID-19 infections are rapidly spreading and have become a global pandemic. Objectives: This study aimed to investigate the association of specific immunological parameters in COVID-19-infected patients in Mosul, Iraq. Materials and Methods: A total of 268 confirmed COVID-19 patients were enrolled in this study (129 males and 139 females). One hundred seventy-nine healthy participants were chosen randomly (81 males and 98 females) as a control. All patients admitted to Al-Salam Teaching Hospital, Iraq from February to May 2021 were included in the study. Blood samples were collected from the participants for serum to estimate levels of C-reactive protein (CRP), interleukin-6 (IL-6), and interleukin-10 (IL-10) using an enzyme-linked immunosorbent assay technique. The total white blood cells (WBC), neutrophils, lymphocytes, and monocytes were also measured. Results: This study revealed that most COVID-19 patients showed high levels of serum CRP, IL-6, and IL-10. The patients with COVID-19 had a significantly higher total WBC count than healthy controls, with 12.21 and 6.93 cells per 103/L, respectively. However, the results showed a reduction in lymphocyte counts in COVID-19 patients. The hematological analysis was statistically significant for all parameters that were estimated in all COVID-19 patients, and controls and was compatible with clinical significance (P = 0.005). Conclusion: Infections with COVID-19 may elevate the levels of serum CRP, IL-6, and IL-10. Therefore, monitoring these immunological markers is essential, particularly in individuals with severe COVID-19 infection. |
| format | Article |
| id | doaj-art-a2da88a0c52e42ce898ebde2164a090d |
| institution | OA Journals |
| issn | 1812-156X 2312-6760 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj-art-a2da88a0c52e42ce898ebde2164a090d2025-08-20T02:36:46ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602025-04-0122234234810.4103/MJBL.MJBL_36_23Evaluation of Some Immunological Parameters in Patients with COVID-19 in Mosul City, IraqMohammed Fadhil HaddadFawwaz Fadhil AliMohammed H. Sharif AlkatibShihab A. Al-BajariBackground: Coronavirus disease 2019 (COVID-19), also known as severe acute respiratory syndrome coronavirus 2, is a viral disease caused by a coronavirus involved in severe acute respiratory syndrome that causes mild, moderate, and severe respiratory system infections. World Health Organization has documented that COVID-19 infections are rapidly spreading and have become a global pandemic. Objectives: This study aimed to investigate the association of specific immunological parameters in COVID-19-infected patients in Mosul, Iraq. Materials and Methods: A total of 268 confirmed COVID-19 patients were enrolled in this study (129 males and 139 females). One hundred seventy-nine healthy participants were chosen randomly (81 males and 98 females) as a control. All patients admitted to Al-Salam Teaching Hospital, Iraq from February to May 2021 were included in the study. Blood samples were collected from the participants for serum to estimate levels of C-reactive protein (CRP), interleukin-6 (IL-6), and interleukin-10 (IL-10) using an enzyme-linked immunosorbent assay technique. The total white blood cells (WBC), neutrophils, lymphocytes, and monocytes were also measured. Results: This study revealed that most COVID-19 patients showed high levels of serum CRP, IL-6, and IL-10. The patients with COVID-19 had a significantly higher total WBC count than healthy controls, with 12.21 and 6.93 cells per 103/L, respectively. However, the results showed a reduction in lymphocyte counts in COVID-19 patients. The hematological analysis was statistically significant for all parameters that were estimated in all COVID-19 patients, and controls and was compatible with clinical significance (P = 0.005). Conclusion: Infections with COVID-19 may elevate the levels of serum CRP, IL-6, and IL-10. Therefore, monitoring these immunological markers is essential, particularly in individuals with severe COVID-19 infection.https://doi.org/10.4103/MJBL.MJBL_36_23covid-19crpil-10il-6immunological parameters |
| spellingShingle | Mohammed Fadhil Haddad Fawwaz Fadhil Ali Mohammed H. Sharif Alkatib Shihab A. Al-Bajari Evaluation of Some Immunological Parameters in Patients with COVID-19 in Mosul City, Iraq Medical Journal of Babylon covid-19 crp il-10 il-6 immunological parameters |
| title | Evaluation of Some Immunological Parameters in Patients with COVID-19 in Mosul City, Iraq |
| title_full | Evaluation of Some Immunological Parameters in Patients with COVID-19 in Mosul City, Iraq |
| title_fullStr | Evaluation of Some Immunological Parameters in Patients with COVID-19 in Mosul City, Iraq |
| title_full_unstemmed | Evaluation of Some Immunological Parameters in Patients with COVID-19 in Mosul City, Iraq |
| title_short | Evaluation of Some Immunological Parameters in Patients with COVID-19 in Mosul City, Iraq |
| title_sort | evaluation of some immunological parameters in patients with covid 19 in mosul city iraq |
| topic | covid-19 crp il-10 il-6 immunological parameters |
| url | https://doi.org/10.4103/MJBL.MJBL_36_23 |
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