Development and validation of LC-MS/MS method for tomivosertib quantification in plasma: insights into pharmacokinetics and metabolic stability

Development and validation of LC-MS/MS method for tomivosertib quantification in plasma: insights into pharmacokinetics and metabolic stability

Abstract A rapid, selective, and sensitive liquid chromatography-tandem mass spectrometry (LC–MS/MS) assay was developed and validated for quantifying tomivosertib (eFT508) in plasma from preclinical animals (rat and mouse). Tomivosertib was quantified using LC–MS/MS assay involving simple protein p...

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Bibliographic Details
Main Authors: Mamata Panthi, Romit Kumar Subba, Ji-Hoon Oh, Dang-Khoa Vo, Kwang-Hoon Chun, Han-Joo Maeng
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:Journal of Analytical Science and Technology
Subjects:
LC–MS/MS
Validation
Pharmacokinetic
Plasma
Tomivosertib
Online Access:https://doi.org/10.1186/s40543-025-00500-5
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