Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment
Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder mainly in middle-elderly population, which represents diverse nonmotor symptoms (NMS) besides such well-documented motor symptoms as bradykinesia, resting tremor, rigidity, and postural instability. With the ad...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2020/2076942 |
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| author | Congcong Fang Longqin Lv Shanping Mao Huimin Dong Baohui Liu |
| author_facet | Congcong Fang Longqin Lv Shanping Mao Huimin Dong Baohui Liu |
| author_sort | Congcong Fang |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder mainly in middle-elderly population, which represents diverse nonmotor symptoms (NMS) besides such well-documented motor symptoms as bradykinesia, resting tremor, rigidity, and postural instability. With the advancement of aging trend worldwide, the global prevalence of PD is mounting up year after year. Nowadays, accumulating lines of studies have given a comprehensive and thorough coverage of motor symptoms in PD. Yet much less attention as compared has been paid to the nonmotor symptoms of PD, such as cognition deficits. Of note, a patient with PD who suffers from cognitive impairment may harbour a statistically significantly higher risk of progressing toward dementia, which negatively affects their life expectancy and daily functioning and overall lowers the global quality of life. Furthermore, it is a widely held view that cognitive dysfunction does not just occur in the late stage of PD. On the basis of numerous studies, mild cognitive impairment (MCI) is a harbinger of dementia in PD, which is observed as an intermediate state with considerable variability; some patients remain stable and some even revert to normal cognition. Considered that the timing, profile, and rate of cognitive impairment vary greatly among PD individuals, it is extremely urgent for researchers and clinicians alike to identify and predict future cognitive decline in this population. Simultaneously, early screening and canonical management of PD with cognitive deficits are very imperative to postpone the disease progression and improve the prognosis of patients. In our review, we focus on a description of cognitive decline in PD, expound emphatically the pathological mechanisms underlying cognition deficits in PD, then give a comprehensive overview of specific therapeutic strategies, and finally dissect what fresh insights may bring new exciting prospect for the subfield. |
| format | Article |
| id | doaj-art-a2cf9771951a4920ab9f7593702991e7 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-a2cf9771951a4920ab9f7593702991e72025-02-03T01:28:16ZengWileyParkinson's Disease2090-80832042-00802020-01-01202010.1155/2020/20769422076942Cognition Deficits in Parkinson’s Disease: Mechanisms and TreatmentCongcong Fang0Longqin Lv1Shanping Mao2Huimin Dong3Baohui Liu4Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaParkinson’s disease (PD) is the second most common progressive neurodegenerative disorder mainly in middle-elderly population, which represents diverse nonmotor symptoms (NMS) besides such well-documented motor symptoms as bradykinesia, resting tremor, rigidity, and postural instability. With the advancement of aging trend worldwide, the global prevalence of PD is mounting up year after year. Nowadays, accumulating lines of studies have given a comprehensive and thorough coverage of motor symptoms in PD. Yet much less attention as compared has been paid to the nonmotor symptoms of PD, such as cognition deficits. Of note, a patient with PD who suffers from cognitive impairment may harbour a statistically significantly higher risk of progressing toward dementia, which negatively affects their life expectancy and daily functioning and overall lowers the global quality of life. Furthermore, it is a widely held view that cognitive dysfunction does not just occur in the late stage of PD. On the basis of numerous studies, mild cognitive impairment (MCI) is a harbinger of dementia in PD, which is observed as an intermediate state with considerable variability; some patients remain stable and some even revert to normal cognition. Considered that the timing, profile, and rate of cognitive impairment vary greatly among PD individuals, it is extremely urgent for researchers and clinicians alike to identify and predict future cognitive decline in this population. Simultaneously, early screening and canonical management of PD with cognitive deficits are very imperative to postpone the disease progression and improve the prognosis of patients. In our review, we focus on a description of cognitive decline in PD, expound emphatically the pathological mechanisms underlying cognition deficits in PD, then give a comprehensive overview of specific therapeutic strategies, and finally dissect what fresh insights may bring new exciting prospect for the subfield.http://dx.doi.org/10.1155/2020/2076942 |
| spellingShingle | Congcong Fang Longqin Lv Shanping Mao Huimin Dong Baohui Liu Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment Parkinson's Disease |
| title | Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment |
| title_full | Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment |
| title_fullStr | Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment |
| title_full_unstemmed | Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment |
| title_short | Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment |
| title_sort | cognition deficits in parkinson s disease mechanisms and treatment |
| url | http://dx.doi.org/10.1155/2020/2076942 |
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