3,3′,5,5′-Tetrabromobiphenyl (BB-80) and Its Hydroxylation Product (OH-BB-80) Mediate Immunotoxicity and Inhibit Embryonic Development in Zebrafish (<i>Danio rerio</i>) via the TLR4/NF-κB Signaling Pathway

3,3′,5,5′-Tetrabromobiphenyl (BB-80) and Its Hydroxylation Product (OH-BB-80) Mediate Immunotoxicity and Inhibit Embryonic Development in Zebrafish (<i>Danio rerio</i>) via the TLR4/NF-κB Signaling Pathway

Polybrominated biphenyls (PBBs) are metabolically transformed into monohydroxylated PBBs (OH-PBBs) in the environment and living organisms. Although OH-PBBs pose a significant health threat to organisms, little is known about the immunotoxicity of OH-PBBs. Therefore, the objectives of this study wer...

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Bibliographic Details
Main Authors: Yongjian Shao, Yinan Zhang, Xiaofang Zhang, Yu Han, Zhiquan Liu, Jiafeng Ding, Binhao Wang, Hangjun Zhang
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Toxics
Subjects:
immunotoxicity
inflammation
oxidative stress
TLR4/NF-κB
zebrafish
Online Access:https://www.mdpi.com/2305-6304/13/4/293
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