Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy
<p>Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-<mml:math alttext="$alpha$"> <mml:mi>α</mml:mi> </mml:math>: TNF-<mml:math alttext="$alpha$&...
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| Format: | Article |
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| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/97257 |
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| description | <p>Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-<mml:math alttext="$alpha$"> <mml:mi>α</mml:mi> </mml:math>: TNF-<mml:math alttext="$alpha$"> <mml:mi>α</mml:mi> </mml:math>), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to general and spinal anaesthesia groups (<mml:math alttext="$n=7$"> <mml:mi>n</mml:mi> <mml:mo>=</mml:mo> <mml:mn>7</mml:mn> </mml:math>). Blood samples were drawn before induction and 24 hours after surgery. Perioperative levels of IL-6, TNF-<mml:math alttext="$alpha$"> <mml:mi>α</mml:mi> </mml:math>, CRP, cortisol, and leptin were comparable among the groups. Twenty four hours after surgery, TNF-<mml:math alttext="$alpha$"> <mml:mi>α</mml:mi> </mml:math> and cortisol did not change; IL-6 and CRP increased significantly in all patients. Significant increase in leptin levels was found in patients undergoing spinal anaesthesia. Except for the increase in leptin levels, there was no significant difference related to the effects of general and spinal anaesthesia.</p> |
| format | Article |
| id | doaj-art-a2c955e0cd5345d9b79a61e4a6eedb00 |
| institution | OA Journals |
| issn | 0962-9351 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a2c955e0cd5345d9b79a61e4a6eedb002025-08-20T02:20:45ZengWileyMediators of Inflammation0962-93512006-01-012006Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy<p>Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-<mml:math alttext="$alpha$"> <mml:mi>α</mml:mi> </mml:math>: TNF-<mml:math alttext="$alpha$"> <mml:mi>α</mml:mi> </mml:math>), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to general and spinal anaesthesia groups (<mml:math alttext="$n=7$"> <mml:mi>n</mml:mi> <mml:mo>=</mml:mo> <mml:mn>7</mml:mn> </mml:math>). Blood samples were drawn before induction and 24 hours after surgery. Perioperative levels of IL-6, TNF-<mml:math alttext="$alpha$"> <mml:mi>α</mml:mi> </mml:math>, CRP, cortisol, and leptin were comparable among the groups. Twenty four hours after surgery, TNF-<mml:math alttext="$alpha$"> <mml:mi>α</mml:mi> </mml:math> and cortisol did not change; IL-6 and CRP increased significantly in all patients. Significant increase in leptin levels was found in patients undergoing spinal anaesthesia. Except for the increase in leptin levels, there was no significant difference related to the effects of general and spinal anaesthesia.</p>http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/97257 |
| spellingShingle | Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy Mediators of Inflammation |
| title | Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy |
| title_full | Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy |
| title_fullStr | Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy |
| title_full_unstemmed | Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy |
| title_short | Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy |
| title_sort | similar effects of general and spinal anaesthesia on perioperative stress response in patients undergoing haemorrhoidectomy |
| url | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/97257 |