Th17 Response and Inflammatory Autoimmune Diseases
The proinflammatory activity of T helper 17 (Th17) cells can be beneficial to the host during infection. However, uncontrolled or inappropriate Th17 activation has been linked to several autoimmune and autoinflammatory pathologies. Indeed, preclinical and clinical data show that Th17 cells are assoc...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/819467 |
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| _version_ | 1849399389657759744 |
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| author | Janelle C. Waite Dimitris Skokos |
| author_facet | Janelle C. Waite Dimitris Skokos |
| author_sort | Janelle C. Waite |
| collection | DOAJ |
| description | The proinflammatory activity of T helper 17 (Th17) cells can be beneficial to the host during infection. However, uncontrolled or inappropriate Th17 activation has been linked to several autoimmune and autoinflammatory pathologies. Indeed, preclinical and clinical data show that Th17 cells are associated with several autoimmune diseases such as arthritis, multiple sclerosis, psoriasis, and lupus. Furthermore, targeting the interleukin-17 (IL-17) pathway has attenuated disease severity in preclinical models of autoimmune diseases. Interestingly, a recent report brings to light a potential role for Th17 cells in the autoinflammatory disorder adult-onset Still's disease (AOSD). Whether Th17 cells are the cause or are directly involved in AOSD remains to be shown. In this paper, we discuss the biology of Th17 cells, their role in autoimmune disease development, and in AOSD in particular, as well as the growing interest of the pharmaceutical industry in their use as therapeutic targets. |
| format | Article |
| id | doaj-art-a2c8f0eb65ca449e8da0d40958190824 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-a2c8f0eb65ca449e8da0d409581908242025-08-20T03:38:19ZengWileyInternational Journal of Inflammation2090-80402042-00992012-01-01201210.1155/2012/819467819467Th17 Response and Inflammatory Autoimmune DiseasesJanelle C. Waite0Dimitris Skokos1Department of Immunity and Inflammation, Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USADepartment of Immunity and Inflammation, Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USAThe proinflammatory activity of T helper 17 (Th17) cells can be beneficial to the host during infection. However, uncontrolled or inappropriate Th17 activation has been linked to several autoimmune and autoinflammatory pathologies. Indeed, preclinical and clinical data show that Th17 cells are associated with several autoimmune diseases such as arthritis, multiple sclerosis, psoriasis, and lupus. Furthermore, targeting the interleukin-17 (IL-17) pathway has attenuated disease severity in preclinical models of autoimmune diseases. Interestingly, a recent report brings to light a potential role for Th17 cells in the autoinflammatory disorder adult-onset Still's disease (AOSD). Whether Th17 cells are the cause or are directly involved in AOSD remains to be shown. In this paper, we discuss the biology of Th17 cells, their role in autoimmune disease development, and in AOSD in particular, as well as the growing interest of the pharmaceutical industry in their use as therapeutic targets.http://dx.doi.org/10.1155/2012/819467 |
| spellingShingle | Janelle C. Waite Dimitris Skokos Th17 Response and Inflammatory Autoimmune Diseases International Journal of Inflammation |
| title | Th17 Response and Inflammatory Autoimmune Diseases |
| title_full | Th17 Response and Inflammatory Autoimmune Diseases |
| title_fullStr | Th17 Response and Inflammatory Autoimmune Diseases |
| title_full_unstemmed | Th17 Response and Inflammatory Autoimmune Diseases |
| title_short | Th17 Response and Inflammatory Autoimmune Diseases |
| title_sort | th17 response and inflammatory autoimmune diseases |
| url | http://dx.doi.org/10.1155/2012/819467 |
| work_keys_str_mv | AT janellecwaite th17responseandinflammatoryautoimmunediseases AT dimitrisskokos th17responseandinflammatoryautoimmunediseases |