Urban-rural difference in adverse outcomes of pulmonary tuberculosis in patients with pulmonary tuberculosis-diabetes mellitus comorbidity
Objective:To investigate the urban and rural differences in adverse outcomes of pulmonary tuberculosis (PTB) in patients with pulmonary tuberculosis-diabetes mellitus comorbidity (PTB-DM), so as to provide insights into improving the prevention and treatment measures for PTB-DM. Methods:Patients wit...
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Editorial Office of China Preventive Medicine Journal
2025-01-01
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| Series: | 预防医学 |
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| Online Access: | http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2025.01.002 |
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| author | FANG Zijian, LI Qingchun，XIE Li，SONG Xu，DAI Ruoqi，WU Yifei，JIA Qingjun，CHENG Qinglin |
| author_facet | FANG Zijian, LI Qingchun，XIE Li，SONG Xu，DAI Ruoqi，WU Yifei，JIA Qingjun，CHENG Qinglin |
| author_sort | FANG Zijian, LI Qingchun，XIE Li，SONG Xu，DAI Ruoqi，WU Yifei，JIA Qingjun，CHENG Qinglin |
| collection | DOAJ |
| description | Objective:To investigate the urban and rural differences in adverse outcomes of pulmonary tuberculosis (PTB) in patients with pulmonary tuberculosis-diabetes mellitus comorbidity (PTB-DM), so as to provide insights into improving the prevention and treatment measures for PTB-DM. Methods:Patients with PTB-DM who were admitted and discharged from 14 designated tuberculosis hospitals in Hangzhou City from 2018 to 2022 were selected. Basic information, and history of diagnosis and treatment were collected through hospital information systems. The adverse outcomes of PTB were defined as endpoints, and the proportions of adverse outcomes of PTB in urban and rural patients with PTB-DM were analyzed. Factors affecting the adverse outcomes of PTB were identified using a multivariable Cox proportional hazards regression model. Results:A total of 823 patients with PTB-DM were enrolled, including 354 (43.01%) urban and 469 (56.99%) rural patients. There were 112 (13.61%) patients with adverse outcomes of PTB. The proportions of adverse outcomes of PTB in urban and rural patients were 14.41% and 13.01%, respectively, with no statistically significant difference (P>0.05). Multivariable Cox proportional hazards regression analysis identified first diagnosed in county-level hospitals or above (HR=2.107, 95%CI: 1.181-3.758) and drug resistance (HR=3.303, 95%CI: 1.653-6.600) as the risk factors for adverse outcomes of PTB in urban patients with PTB-DM, while the treatment/observed management throughout the process (HR=0.470, 95%CI: 0.274-0.803) and fixed-dose combinations throughout the process (HR=0.331, 95%CI: 0.151-0.729) as the protective factors for adverse outcomes in rural patients with PTB-DM. Conclusions:There are differences in influencing factors for adverse outcomes of PTB in urban and rural patients with PTB-DM. The adverse outcomes of PTB are associated with first diagnosed hospitals and drug resistance in urban patients, and are associated with the treatment/observed management and fixed-dose combinations throughout the process in rural patients. |
| format | Article |
| id | doaj-art-a2c7c94eddae42b4917c341ed3fac291 |
| institution | Kabale University |
| issn | 2096-5087 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of China Preventive Medicine Journal |
| record_format | Article |
| series | 预防医学 |
| spelling | doaj-art-a2c7c94eddae42b4917c341ed3fac2912025-02-07T06:06:25ZzhoEditorial Office of China Preventive Medicine Journal预防医学2096-50872025-01-0137171110.19485/j.cnki.issn2096-5087.2025.01.002Urban-rural difference in adverse outcomes of pulmonary tuberculosis in patients with pulmonary tuberculosis-diabetes mellitus comorbidityFANG Zijian, LI Qingchun，XIE Li，SONG Xu，DAI Ruoqi，WU Yifei，JIA Qingjun，CHENG QinglinObjective:To investigate the urban and rural differences in adverse outcomes of pulmonary tuberculosis (PTB) in patients with pulmonary tuberculosis-diabetes mellitus comorbidity (PTB-DM), so as to provide insights into improving the prevention and treatment measures for PTB-DM. Methods:Patients with PTB-DM who were admitted and discharged from 14 designated tuberculosis hospitals in Hangzhou City from 2018 to 2022 were selected. Basic information, and history of diagnosis and treatment were collected through hospital information systems. The adverse outcomes of PTB were defined as endpoints, and the proportions of adverse outcomes of PTB in urban and rural patients with PTB-DM were analyzed. Factors affecting the adverse outcomes of PTB were identified using a multivariable Cox proportional hazards regression model. Results:A total of 823 patients with PTB-DM were enrolled, including 354 (43.01%) urban and 469 (56.99%) rural patients. There were 112 (13.61%) patients with adverse outcomes of PTB. The proportions of adverse outcomes of PTB in urban and rural patients were 14.41% and 13.01%, respectively, with no statistically significant difference (P>0.05). Multivariable Cox proportional hazards regression analysis identified first diagnosed in county-level hospitals or above (HR=2.107, 95%CI: 1.181-3.758) and drug resistance (HR=3.303, 95%CI: 1.653-6.600) as the risk factors for adverse outcomes of PTB in urban patients with PTB-DM, while the treatment/observed management throughout the process (HR=0.470, 95%CI: 0.274-0.803) and fixed-dose combinations throughout the process (HR=0.331, 95%CI: 0.151-0.729) as the protective factors for adverse outcomes in rural patients with PTB-DM. Conclusions:There are differences in influencing factors for adverse outcomes of PTB in urban and rural patients with PTB-DM. The adverse outcomes of PTB are associated with first diagnosed hospitals and drug resistance in urban patients, and are associated with the treatment/observed management and fixed-dose combinations throughout the process in rural patients.http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2025.01.002pulmonary tuberculosisdiabetes mellituscomorbidityadverse outcomeurban-rural difference |
| spellingShingle | FANG Zijian, LI Qingchun，XIE Li，SONG Xu，DAI Ruoqi，WU Yifei，JIA Qingjun，CHENG Qinglin Urban-rural difference in adverse outcomes of pulmonary tuberculosis in patients with pulmonary tuberculosis-diabetes mellitus comorbidity 预防医学 pulmonary tuberculosis diabetes mellitus comorbidity adverse outcome urban-rural difference |
| title | Urban-rural difference in adverse outcomes of pulmonary tuberculosis in patients with pulmonary tuberculosis-diabetes mellitus comorbidity |
| title_full | Urban-rural difference in adverse outcomes of pulmonary tuberculosis in patients with pulmonary tuberculosis-diabetes mellitus comorbidity |
| title_fullStr | Urban-rural difference in adverse outcomes of pulmonary tuberculosis in patients with pulmonary tuberculosis-diabetes mellitus comorbidity |
| title_full_unstemmed | Urban-rural difference in adverse outcomes of pulmonary tuberculosis in patients with pulmonary tuberculosis-diabetes mellitus comorbidity |
| title_short | Urban-rural difference in adverse outcomes of pulmonary tuberculosis in patients with pulmonary tuberculosis-diabetes mellitus comorbidity |
| title_sort | urban rural difference in adverse outcomes of pulmonary tuberculosis in patients with pulmonary tuberculosis diabetes mellitus comorbidity |
| topic | pulmonary tuberculosis diabetes mellitus comorbidity adverse outcome urban-rural difference |
| url | http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2025.01.002 |
| work_keys_str_mv | AT fangzijianliqingchunxielisongxudairuoqiwuyifeijiaqingjunchengqinglin urbanruraldifferenceinadverseoutcomesofpulmonarytuberculosisinpatientswithpulmonarytuberculosisdiabetesmellituscomorbidity |