Methods of forensic examination of Nalbuphine
The article discusses the peculiarities of forensic examination of nalbuphine hydrochloride, a prescription medicine that can be purchased without a prescription in many pharmacies. At present, in Ukraine, nalbuphine is not subject to subject-quantitative accounting in healthcare facilities and by p...
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| Format: | Article |
| Language: | Ukrainian |
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Kharkiv National University of Internal Affairs
2024-03-01
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| Series: | Bulletin of Kharkiv National University of Internal Affairs |
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| Online Access: | https://visnyk.univd.edu.ua/index.php/VNUAF/article/view/714 |
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| author | I. О. Besedina |
| author_facet | I. О. Besedina |
| author_sort | I. О. Besedina |
| collection | DOAJ |
| description | The article discusses the peculiarities of forensic examination of nalbuphine hydrochloride, a prescription medicine that can be purchased without a prescription in many pharmacies. At present, in Ukraine, nalbuphine is not subject to subject-quantitative accounting in healthcare facilities and by pharmaceutical manufacturers, but in some countries it is included in the list of narcotic drugs. It is emphasised that nalbuphine hydrochloride is a synthetic opioid analgesic, which is chemically similar to morphine and phenanthrene. In terms of pharmacological action, it belongs to the group of opioid receptor agonists-antagonists (pentazocine, buprenorphine, butorphanol).
The article provides a brief overview of the effectiveness of nalbuphine for pain relief in various cases, as well as examples of abuse of opioids in combination preparations and facts of non-medical use of nalbuphine. The effectiveness of opioids as painkillers is undeniable, but today, given the risk/benefit ratio, the expediency of their long-term use is questionable. There are more and more recommendations to avoid the use of opioids. Nalbuphine in combination with other psychotropic substances, medicines and in large doses is life-threatening, so it is proposed to further study and control it more deeply at the state level by amending the Resolution of the Cabinet of Ministers of Ukraine “On Approval of the List of Narcotic Drugs, Psychotropic Substances and Precursors” of 6 May 2000 No. 770, in particular, to classify nalbuphine as a narcotic drug.
The article analyses the peculiarities of sampling and sample preparation, the main stages of chemical research of this potentially dangerous opioid using thin-layer chromatography, infrared spectroscopy, gas chromatography with a mass-selective detector. It is emphasised that the experimental data presented in the article will help in choosing the most appropriate methods and conditions for the study of nalbuphine, and will allow an objective assessment of the results of expert research. |
| format | Article |
| id | doaj-art-a2c292a8f87a47e6b748db2abea61de9 |
| institution | Kabale University |
| issn | 1999-5717 2617-278X |
| language | Ukrainian |
| publishDate | 2024-03-01 |
| publisher | Kharkiv National University of Internal Affairs |
| record_format | Article |
| series | Bulletin of Kharkiv National University of Internal Affairs |
| spelling | doaj-art-a2c292a8f87a47e6b748db2abea61de92025-02-02T22:19:50ZukrKharkiv National University of Internal AffairsBulletin of Kharkiv National University of Internal Affairs1999-57172617-278X2024-03-011041 (Part 1)16317510.32631/v.2024.1.14714Methods of forensic examination of NalbuphineI. О. Besedina0Kharkiv Scientific Research Expert and Criminalistic Center of the Ministry of Internal Affairs of UkraineThe article discusses the peculiarities of forensic examination of nalbuphine hydrochloride, a prescription medicine that can be purchased without a prescription in many pharmacies. At present, in Ukraine, nalbuphine is not subject to subject-quantitative accounting in healthcare facilities and by pharmaceutical manufacturers, but in some countries it is included in the list of narcotic drugs. It is emphasised that nalbuphine hydrochloride is a synthetic opioid analgesic, which is chemically similar to morphine and phenanthrene. In terms of pharmacological action, it belongs to the group of opioid receptor agonists-antagonists (pentazocine, buprenorphine, butorphanol). The article provides a brief overview of the effectiveness of nalbuphine for pain relief in various cases, as well as examples of abuse of opioids in combination preparations and facts of non-medical use of nalbuphine. The effectiveness of opioids as painkillers is undeniable, but today, given the risk/benefit ratio, the expediency of their long-term use is questionable. There are more and more recommendations to avoid the use of opioids. Nalbuphine in combination with other psychotropic substances, medicines and in large doses is life-threatening, so it is proposed to further study and control it more deeply at the state level by amending the Resolution of the Cabinet of Ministers of Ukraine “On Approval of the List of Narcotic Drugs, Psychotropic Substances and Precursors” of 6 May 2000 No. 770, in particular, to classify nalbuphine as a narcotic drug. The article analyses the peculiarities of sampling and sample preparation, the main stages of chemical research of this potentially dangerous opioid using thin-layer chromatography, infrared spectroscopy, gas chromatography with a mass-selective detector. It is emphasised that the experimental data presented in the article will help in choosing the most appropriate methods and conditions for the study of nalbuphine, and will allow an objective assessment of the results of expert research.https://visnyk.univd.edu.ua/index.php/VNUAF/article/view/714nalbuphineresearchopioids, drug addictionthin-layer chromatographyinfrared spectrometrychromatography-mass spectrometry. |
| spellingShingle | I. О. Besedina Methods of forensic examination of Nalbuphine Bulletin of Kharkiv National University of Internal Affairs nalbuphine research opioids, drug addiction thin-layer chromatography infrared spectrometry chromatography-mass spectrometry. |
| title | Methods of forensic examination of Nalbuphine |
| title_full | Methods of forensic examination of Nalbuphine |
| title_fullStr | Methods of forensic examination of Nalbuphine |
| title_full_unstemmed | Methods of forensic examination of Nalbuphine |
| title_short | Methods of forensic examination of Nalbuphine |
| title_sort | methods of forensic examination of nalbuphine |
| topic | nalbuphine research opioids, drug addiction thin-layer chromatography infrared spectrometry chromatography-mass spectrometry. |
| url | https://visnyk.univd.edu.ua/index.php/VNUAF/article/view/714 |
| work_keys_str_mv | AT iobesedina methodsofforensicexaminationofnalbuphine |