Identifying individuals at-risk of developing Parkinson’s disease using a population-based recruitment strategy: The Healthy Brain Ageing Kassel Study
Abstract Neurodegeneration in Parkinson’s disease (PD) occurs before motor features develop: assessing risk factors and identifying prodromal markers is necessary to recruit prodromal cohorts, improve early diagnosis, and develop preventive therapies. As part of Healthy Brain Ageing (HeBA), we imple...
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| Format: | Article |
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Nature Portfolio
2025-07-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01008-w |
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| author | Sebastian Schade Soumyabrata Ghosh Alicia Garrido Philipp Mahlknecht Tainá M. Marques Corinne G. C. Horlings Sonja R. Jónsdóttir Elisabeth Lang Claire Pauly Kavita Rege Susana Schnell Maritta Starke Horst Hakelberg Eduardo Tolosa Claudia Trenkwalder Tamara Wicke Healthy Brain Ageing (HeBA) Consortium Rejko Krüger Maria J. Marti Werner Poewe Venkata P. Satagopam Brit Mollenhauer |
| author_facet | Sebastian Schade Soumyabrata Ghosh Alicia Garrido Philipp Mahlknecht Tainá M. Marques Corinne G. C. Horlings Sonja R. Jónsdóttir Elisabeth Lang Claire Pauly Kavita Rege Susana Schnell Maritta Starke Horst Hakelberg Eduardo Tolosa Claudia Trenkwalder Tamara Wicke Healthy Brain Ageing (HeBA) Consortium Rejko Krüger Maria J. Marti Werner Poewe Venkata P. Satagopam Brit Mollenhauer |
| author_sort | Sebastian Schade |
| collection | DOAJ |
| description | Abstract Neurodegeneration in Parkinson’s disease (PD) occurs before motor features develop: assessing risk factors and identifying prodromal markers is necessary to recruit prodromal cohorts, improve early diagnosis, and develop preventive therapies. As part of Healthy Brain Ageing (HeBA), we implemented a stepwise, population-based screening to identify people at high risk of developing PD. Residents (n = 158,818; 50-80 years) in and around Kassel, Germany were invited to complete an online survey with questions for prodromal symptoms and risk factors. An individual risk score was calculated (International Parkinson and Movement Disorder Society criteria). Selected individuals received a smell test. 8001 of 8774 survey responses were valid; the response rate to the smell test mailings (n = 3021) was 90%. Hyposmic participants (n = 1019) had more subjective hyposmia and subjective memory impairment (p < 0.01). Follow-up visits will validate the recruitment strategy and monitor conversion to manifest PD. Our recruitment strategy identifies people who might be at risk for PD. |
| format | Article |
| id | doaj-art-a2bd5725c8b9421dbefb1f30ebf5a281 |
| institution | DOAJ |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-a2bd5725c8b9421dbefb1f30ebf5a2812025-08-20T03:04:26ZengNature Portfolionpj Parkinson's Disease2373-80572025-07-0111111010.1038/s41531-025-01008-wIdentifying individuals at-risk of developing Parkinson’s disease using a population-based recruitment strategy: The Healthy Brain Ageing Kassel StudySebastian Schade0Soumyabrata Ghosh1Alicia Garrido2Philipp Mahlknecht3Tainá M. Marques4Corinne G. C. Horlings5Sonja R. Jónsdóttir6Elisabeth Lang7Claire Pauly8Kavita Rege9Susana Schnell10Maritta Starke11Horst Hakelberg12Eduardo Tolosa13Claudia Trenkwalder14Tamara Wicke15Healthy Brain Ageing (HeBA) ConsortiumRejko Krüger16Maria J. Marti17Werner Poewe18Venkata P. Satagopam19Brit Mollenhauer20Paracelsus-Elena-Klinik KasselLuxembourg Centre for Systems Biomedicine (LCSB), University of LuxembourgParkinson’s disease & Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED: CB06/05/0018-ISCIII)Department of Neurology, Medical University of InnsbruckLuxembourg Institute of Health (LIH)Department of Neurology, Medical University of InnsbruckLuxembourg Institute of Health (LIH)Paracelsus-Elena-Klinik KasselLuxembourg Institute of Health (LIH)Luxembourg Centre for Systems Biomedicine (LCSB), University of LuxembourgParacelsus-Elena-Klinik KasselParacelsus-Elena-Klinik KasselParacelsus-Elena-Klinik KasselParkinson’s disease & Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED: CB06/05/0018-ISCIII)Paracelsus-Elena-Klinik KasselParacelsus-Elena-Klinik KasselLuxembourg Centre for Systems Biomedicine (LCSB), University of LuxembourgParkinson’s disease & Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED: CB06/05/0018-ISCIII)Department of Neurology, Medical University of InnsbruckLuxembourg Centre for Systems Biomedicine (LCSB), University of LuxembourgParacelsus-Elena-Klinik KasselAbstract Neurodegeneration in Parkinson’s disease (PD) occurs before motor features develop: assessing risk factors and identifying prodromal markers is necessary to recruit prodromal cohorts, improve early diagnosis, and develop preventive therapies. As part of Healthy Brain Ageing (HeBA), we implemented a stepwise, population-based screening to identify people at high risk of developing PD. Residents (n = 158,818; 50-80 years) in and around Kassel, Germany were invited to complete an online survey with questions for prodromal symptoms and risk factors. An individual risk score was calculated (International Parkinson and Movement Disorder Society criteria). Selected individuals received a smell test. 8001 of 8774 survey responses were valid; the response rate to the smell test mailings (n = 3021) was 90%. Hyposmic participants (n = 1019) had more subjective hyposmia and subjective memory impairment (p < 0.01). Follow-up visits will validate the recruitment strategy and monitor conversion to manifest PD. Our recruitment strategy identifies people who might be at risk for PD.https://doi.org/10.1038/s41531-025-01008-w |
| spellingShingle | Sebastian Schade Soumyabrata Ghosh Alicia Garrido Philipp Mahlknecht Tainá M. Marques Corinne G. C. Horlings Sonja R. Jónsdóttir Elisabeth Lang Claire Pauly Kavita Rege Susana Schnell Maritta Starke Horst Hakelberg Eduardo Tolosa Claudia Trenkwalder Tamara Wicke Healthy Brain Ageing (HeBA) Consortium Rejko Krüger Maria J. Marti Werner Poewe Venkata P. Satagopam Brit Mollenhauer Identifying individuals at-risk of developing Parkinson’s disease using a population-based recruitment strategy: The Healthy Brain Ageing Kassel Study npj Parkinson's Disease |
| title | Identifying individuals at-risk of developing Parkinson’s disease using a population-based recruitment strategy: The Healthy Brain Ageing Kassel Study |
| title_full | Identifying individuals at-risk of developing Parkinson’s disease using a population-based recruitment strategy: The Healthy Brain Ageing Kassel Study |
| title_fullStr | Identifying individuals at-risk of developing Parkinson’s disease using a population-based recruitment strategy: The Healthy Brain Ageing Kassel Study |
| title_full_unstemmed | Identifying individuals at-risk of developing Parkinson’s disease using a population-based recruitment strategy: The Healthy Brain Ageing Kassel Study |
| title_short | Identifying individuals at-risk of developing Parkinson’s disease using a population-based recruitment strategy: The Healthy Brain Ageing Kassel Study |
| title_sort | identifying individuals at risk of developing parkinson s disease using a population based recruitment strategy the healthy brain ageing kassel study |
| url | https://doi.org/10.1038/s41531-025-01008-w |
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