Ferroptosis and its impact on common diseases
Ferroptosis is a novel form of programmed cell death characterized by iron accumulation, lipid peroxidation, and a decline in antioxidant capacity, all of which are regulated by gene expression. The onset of numerous diseases is closely associated with ferroptosis. Common diseases affect a large pop...
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PeerJ Inc.
2024-12-01
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author | Pengjian Zou Qiuming He Huimin Xia Wei Zhong |
author_facet | Pengjian Zou Qiuming He Huimin Xia Wei Zhong |
author_sort | Pengjian Zou |
collection | DOAJ |
description | Ferroptosis is a novel form of programmed cell death characterized by iron accumulation, lipid peroxidation, and a decline in antioxidant capacity, all of which are regulated by gene expression. The onset of numerous diseases is closely associated with ferroptosis. Common diseases affect a large population, reduce the quality of life, and impose an increased burden on the healthcare system. The role of ferroptosis in common diseases, its therapeutic potential, and even its translation into clinical drug treatments are currently significant research topics worldwide. This study preliminarily explores the theoretical basis of ferroptosis, its mechanism and treatment prospect in common diseases including ischaemia-reperfusion injury, inflammatory bowel diseases, liver fibrosis, acute kidney injury, diabetic kidney disease, stroke, Alzheimer’s disease, cardiovascular disease, immune and cancer. This review provides a theoretical foundation for the further study and development of ferroptosis, as well as for the prevention and treatment of common diseases. |
format | Article |
id | doaj-art-a2bd06460ee044d892df74d6442a295c |
institution | Kabale University |
issn | 2167-8359 |
language | English |
publishDate | 2024-12-01 |
publisher | PeerJ Inc. |
record_format | Article |
series | PeerJ |
spelling | doaj-art-a2bd06460ee044d892df74d6442a295c2024-12-21T15:05:15ZengPeerJ Inc.PeerJ2167-83592024-12-0112e1870810.7717/peerj.18708Ferroptosis and its impact on common diseasesPengjian ZouQiuming HeHuimin XiaWei ZhongFerroptosis is a novel form of programmed cell death characterized by iron accumulation, lipid peroxidation, and a decline in antioxidant capacity, all of which are regulated by gene expression. The onset of numerous diseases is closely associated with ferroptosis. Common diseases affect a large population, reduce the quality of life, and impose an increased burden on the healthcare system. The role of ferroptosis in common diseases, its therapeutic potential, and even its translation into clinical drug treatments are currently significant research topics worldwide. This study preliminarily explores the theoretical basis of ferroptosis, its mechanism and treatment prospect in common diseases including ischaemia-reperfusion injury, inflammatory bowel diseases, liver fibrosis, acute kidney injury, diabetic kidney disease, stroke, Alzheimer’s disease, cardiovascular disease, immune and cancer. This review provides a theoretical foundation for the further study and development of ferroptosis, as well as for the prevention and treatment of common diseases.https://peerj.com/articles/18708.pdfFerroptosisMechanismInducerInhibitorTreatment |
spellingShingle | Pengjian Zou Qiuming He Huimin Xia Wei Zhong Ferroptosis and its impact on common diseases PeerJ Ferroptosis Mechanism Inducer Inhibitor Treatment |
title | Ferroptosis and its impact on common diseases |
title_full | Ferroptosis and its impact on common diseases |
title_fullStr | Ferroptosis and its impact on common diseases |
title_full_unstemmed | Ferroptosis and its impact on common diseases |
title_short | Ferroptosis and its impact on common diseases |
title_sort | ferroptosis and its impact on common diseases |
topic | Ferroptosis Mechanism Inducer Inhibitor Treatment |
url | https://peerj.com/articles/18708.pdf |
work_keys_str_mv | AT pengjianzou ferroptosisanditsimpactoncommondiseases AT qiuminghe ferroptosisanditsimpactoncommondiseases AT huiminxia ferroptosisanditsimpactoncommondiseases AT weizhong ferroptosisanditsimpactoncommondiseases |