Ferroptosis and its impact on common diseases

Ferroptosis is a novel form of programmed cell death characterized by iron accumulation, lipid peroxidation, and a decline in antioxidant capacity, all of which are regulated by gene expression. The onset of numerous diseases is closely associated with ferroptosis. Common diseases affect a large pop...

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Main Authors: Pengjian Zou, Qiuming He, Huimin Xia, Wei Zhong
Format: Article
Language:English
Published: PeerJ Inc. 2024-12-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/18708.pdf
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author Pengjian Zou
Qiuming He
Huimin Xia
Wei Zhong
author_facet Pengjian Zou
Qiuming He
Huimin Xia
Wei Zhong
author_sort Pengjian Zou
collection DOAJ
description Ferroptosis is a novel form of programmed cell death characterized by iron accumulation, lipid peroxidation, and a decline in antioxidant capacity, all of which are regulated by gene expression. The onset of numerous diseases is closely associated with ferroptosis. Common diseases affect a large population, reduce the quality of life, and impose an increased burden on the healthcare system. The role of ferroptosis in common diseases, its therapeutic potential, and even its translation into clinical drug treatments are currently significant research topics worldwide. This study preliminarily explores the theoretical basis of ferroptosis, its mechanism and treatment prospect in common diseases including ischaemia-reperfusion injury, inflammatory bowel diseases, liver fibrosis, acute kidney injury, diabetic kidney disease, stroke, Alzheimer’s disease, cardiovascular disease, immune and cancer. This review provides a theoretical foundation for the further study and development of ferroptosis, as well as for the prevention and treatment of common diseases.
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institution Kabale University
issn 2167-8359
language English
publishDate 2024-12-01
publisher PeerJ Inc.
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series PeerJ
spelling doaj-art-a2bd06460ee044d892df74d6442a295c2024-12-21T15:05:15ZengPeerJ Inc.PeerJ2167-83592024-12-0112e1870810.7717/peerj.18708Ferroptosis and its impact on common diseasesPengjian ZouQiuming HeHuimin XiaWei ZhongFerroptosis is a novel form of programmed cell death characterized by iron accumulation, lipid peroxidation, and a decline in antioxidant capacity, all of which are regulated by gene expression. The onset of numerous diseases is closely associated with ferroptosis. Common diseases affect a large population, reduce the quality of life, and impose an increased burden on the healthcare system. The role of ferroptosis in common diseases, its therapeutic potential, and even its translation into clinical drug treatments are currently significant research topics worldwide. This study preliminarily explores the theoretical basis of ferroptosis, its mechanism and treatment prospect in common diseases including ischaemia-reperfusion injury, inflammatory bowel diseases, liver fibrosis, acute kidney injury, diabetic kidney disease, stroke, Alzheimer’s disease, cardiovascular disease, immune and cancer. This review provides a theoretical foundation for the further study and development of ferroptosis, as well as for the prevention and treatment of common diseases.https://peerj.com/articles/18708.pdfFerroptosisMechanismInducerInhibitorTreatment
spellingShingle Pengjian Zou
Qiuming He
Huimin Xia
Wei Zhong
Ferroptosis and its impact on common diseases
PeerJ
Ferroptosis
Mechanism
Inducer
Inhibitor
Treatment
title Ferroptosis and its impact on common diseases
title_full Ferroptosis and its impact on common diseases
title_fullStr Ferroptosis and its impact on common diseases
title_full_unstemmed Ferroptosis and its impact on common diseases
title_short Ferroptosis and its impact on common diseases
title_sort ferroptosis and its impact on common diseases
topic Ferroptosis
Mechanism
Inducer
Inhibitor
Treatment
url https://peerj.com/articles/18708.pdf
work_keys_str_mv AT pengjianzou ferroptosisanditsimpactoncommondiseases
AT qiuminghe ferroptosisanditsimpactoncommondiseases
AT huiminxia ferroptosisanditsimpactoncommondiseases
AT weizhong ferroptosisanditsimpactoncommondiseases