Differences in pretreatment symptoms of patients receiving injections or surgery to treat cartilage lesions of the knee: an International Cartilage Regeneration and Joint Preservation Society Patient Registry Study
Introduction: Some patients with cartilage defects of the knee are known to report similar quality of life (QoL) scores to patients listed for total knee arthroplasty. However, it is unknown whether patients waiting to undergo injections for a cartilage injury perceive their symptoms and QoL to be e...
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Elsevier
2024-09-01
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| Series: | Journal of Cartilage & Joint Preservation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667254523000689 |
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| author | Gwenllian F. Tawy Michael J. McNicholas |
| author_facet | Gwenllian F. Tawy Michael J. McNicholas |
| author_sort | Gwenllian F. Tawy |
| collection | DOAJ |
| description | Introduction: Some patients with cartilage defects of the knee are known to report similar quality of life (QoL) scores to patients listed for total knee arthroplasty. However, it is unknown whether patients waiting to undergo injections for a cartilage injury perceive their symptoms and QoL to be equivalent to those awaiting surgery. Objectives: Compare the pretreatment status of patients undergoing a knee injection or surgical intervention for cartilage lesions. The hypothesis was that there would be no clinical difference in scores between the 2 cohorts. Methods: Anonymous data from the International Cartilage Regeneration and Joint Preservation Society Registry were exported: demographics, type of intervention, pretreatment Knee Injury and Osteoarthritis Outcome Scores (KOOS) and Visual Analog Scores (VAS). The required sample size was 273 per cohort. Statistical analyses were used to compare the scores of each cohort (α = 0.05). Results: One thousand five hundred seventy-eight patients were included (993 surgeries vs 585 injections). The surgical cohort was 30 years younger than the injection cohort (P < .0001). There were no clinically significant differences in KOOS or VAS. However, KOOS aggregate scores, KOOS pain, and VAS were statistically poorer in the injection cohort (P < .0001; P = .04; P = .001). KOOS QoL was poorer in the surgical cohort (P < .0001). Conclusions: Our null hypothesis was accepted, as there were no clinically significant differences in the scores. Thus, both cohorts perceived their level of disability and severity of symptoms to be equivalent. Nevertheless, statistical analyses suggested that the younger surgical cohort perceived their QoL to be poorer, while pain levels were worse in the older injection cohort. |
| format | Article |
| id | doaj-art-a2b9086cd13443429490d80b71307e2a |
| institution | OA Journals |
| issn | 2667-2545 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cartilage & Joint Preservation |
| spelling | doaj-art-a2b9086cd13443429490d80b71307e2a2025-08-20T01:47:51ZengElsevierJournal of Cartilage & Joint Preservation2667-25452024-09-014310016210.1016/j.jcjp.2023.100162Differences in pretreatment symptoms of patients receiving injections or surgery to treat cartilage lesions of the knee: an International Cartilage Regeneration and Joint Preservation Society Patient Registry StudyGwenllian F. Tawy0Michael J. McNicholas1International Cartilage Regeneration & Joint Preservation Society, Zurich, Switzerland; Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, The University of Manchester, Manchester, UK; Gwenllian F. Tawy, University of Manchester, 1.541 Stopford Building, Oxford Road, Manchester M13 9PG, UK.Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, The University of Manchester, Manchester, UK; Department of Orthopaedics, Trafford General Hospital, Manchester University NHS Foundation Trust, Manchester, UK; Department of Trauma and Orthopaedics, Broadgreen Hospital, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UKIntroduction: Some patients with cartilage defects of the knee are known to report similar quality of life (QoL) scores to patients listed for total knee arthroplasty. However, it is unknown whether patients waiting to undergo injections for a cartilage injury perceive their symptoms and QoL to be equivalent to those awaiting surgery. Objectives: Compare the pretreatment status of patients undergoing a knee injection or surgical intervention for cartilage lesions. The hypothesis was that there would be no clinical difference in scores between the 2 cohorts. Methods: Anonymous data from the International Cartilage Regeneration and Joint Preservation Society Registry were exported: demographics, type of intervention, pretreatment Knee Injury and Osteoarthritis Outcome Scores (KOOS) and Visual Analog Scores (VAS). The required sample size was 273 per cohort. Statistical analyses were used to compare the scores of each cohort (α = 0.05). Results: One thousand five hundred seventy-eight patients were included (993 surgeries vs 585 injections). The surgical cohort was 30 years younger than the injection cohort (P < .0001). There were no clinically significant differences in KOOS or VAS. However, KOOS aggregate scores, KOOS pain, and VAS were statistically poorer in the injection cohort (P < .0001; P = .04; P = .001). KOOS QoL was poorer in the surgical cohort (P < .0001). Conclusions: Our null hypothesis was accepted, as there were no clinically significant differences in the scores. Thus, both cohorts perceived their level of disability and severity of symptoms to be equivalent. Nevertheless, statistical analyses suggested that the younger surgical cohort perceived their QoL to be poorer, while pain levels were worse in the older injection cohort.http://www.sciencedirect.com/science/article/pii/S2667254523000689Cartilage injuryKnee injectionsKnee surgeryPatient-reported outcomesRegistry |
| spellingShingle | Gwenllian F. Tawy Michael J. McNicholas Differences in pretreatment symptoms of patients receiving injections or surgery to treat cartilage lesions of the knee: an International Cartilage Regeneration and Joint Preservation Society Patient Registry Study Journal of Cartilage & Joint Preservation Cartilage injury Knee injections Knee surgery Patient-reported outcomes Registry |
| title | Differences in pretreatment symptoms of patients receiving injections or surgery to treat cartilage lesions of the knee: an International Cartilage Regeneration and Joint Preservation Society Patient Registry Study |
| title_full | Differences in pretreatment symptoms of patients receiving injections or surgery to treat cartilage lesions of the knee: an International Cartilage Regeneration and Joint Preservation Society Patient Registry Study |
| title_fullStr | Differences in pretreatment symptoms of patients receiving injections or surgery to treat cartilage lesions of the knee: an International Cartilage Regeneration and Joint Preservation Society Patient Registry Study |
| title_full_unstemmed | Differences in pretreatment symptoms of patients receiving injections or surgery to treat cartilage lesions of the knee: an International Cartilage Regeneration and Joint Preservation Society Patient Registry Study |
| title_short | Differences in pretreatment symptoms of patients receiving injections or surgery to treat cartilage lesions of the knee: an International Cartilage Regeneration and Joint Preservation Society Patient Registry Study |
| title_sort | differences in pretreatment symptoms of patients receiving injections or surgery to treat cartilage lesions of the knee an international cartilage regeneration and joint preservation society patient registry study |
| topic | Cartilage injury Knee injections Knee surgery Patient-reported outcomes Registry |
| url | http://www.sciencedirect.com/science/article/pii/S2667254523000689 |
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