Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Injection of the Growth Factors-Rich Catfish Skin-Derived Fraction-B: An Introductory Report
Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells. The regeneration of durable insulin-producing β-cells remains a critical challenge. This study investigated the regenerative potential of Fraction-B (FB), a catfish skin-derived preparation rich in growth fac...
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MDPI AG
2025-06-01
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| author | Jassim M. Al-Hassan Waleed M. Renno Sosamma Oommen Divya Nair Bincy Maniyalil Paul Bincy Mathew Jijin Kumar Afna Ummerkutty Cecil Pace-Asciak |
| author_facet | Jassim M. Al-Hassan Waleed M. Renno Sosamma Oommen Divya Nair Bincy Maniyalil Paul Bincy Mathew Jijin Kumar Afna Ummerkutty Cecil Pace-Asciak |
| author_sort | Jassim M. Al-Hassan |
| collection | DOAJ |
| description | Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells. The regeneration of durable insulin-producing β-cells remains a critical challenge. This study investigated the regenerative potential of Fraction-B (FB), a catfish skin-derived preparation rich in growth factors, in a T1D rat model to regenerate active β-cells. Sprague Dawley rats with T1D caused by streptozotocin injection received daily intraperitoneal injections of FB for 8 weeks. FB treatment significantly reduced blood glucose to a level close to that of normal control animals, increased serum insulin and C-peptide, and restored pancreatic insulin content. Histopathological and immunohistochemical analyses confirmed the regeneration of insulin-producing β-cells in pancreatic islets. FB treatment also improved diabetes-related health issues through a reduction in inflammation and oxidative stress, and an improvement in lipid profiles without toxicity or side effects. The regenerated β-cells remained functional for 48 weeks without the use of immunosuppressants, until the animals were sacrificed. These findings suggest FB treatment to be a promising procedure for translational research into T1D treatment. |
| format | Article |
| id | doaj-art-a2b88d2b446046aab55a5878b2cd1f25 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Biomolecules |
| spelling | doaj-art-a2b88d2b446046aab55a5878b2cd1f252025-08-20T03:58:27ZengMDPI AGBiomolecules2218-273X2025-06-0115792910.3390/biom15070929Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Injection of the Growth Factors-Rich Catfish Skin-Derived Fraction-B: An Introductory ReportJassim M. Al-Hassan0Waleed M. Renno1Sosamma Oommen2Divya Nair3Bincy Maniyalil Paul4Bincy Mathew5Jijin Kumar6Afna Ummerkutty7Cecil Pace-Asciak8Health Sciences Research Centre, Khaldiya Campus, Abdullah Al-Salem University, P.O. Box 2249, Safat 13023, Kuwait City, KuwaitDepartment of Anatomy, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait City, KuwaitHealth Sciences Research Centre, Khaldiya Campus, Abdullah Al-Salem University, P.O. Box 2249, Safat 13023, Kuwait City, KuwaitBiological Sciences Department, Faculty of Science, Shedadiya Campus, Kuwait University, P.O. Box 5969, Safat 13060, KuwaitBiological Sciences Department, Faculty of Science, Shedadiya Campus, Kuwait University, P.O. Box 5969, Safat 13060, KuwaitHealth Sciences Research Centre, Khaldiya Campus, Abdullah Al-Salem University, P.O. Box 2249, Safat 13023, Kuwait City, KuwaitDepartment of Anatomy, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait City, KuwaitHealth Sciences Research Centre, Khaldiya Campus, Abdullah Al-Salem University, P.O. Box 2249, Safat 13023, Kuwait City, KuwaitTranslational Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON M5G OA4, CanadaType 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells. The regeneration of durable insulin-producing β-cells remains a critical challenge. This study investigated the regenerative potential of Fraction-B (FB), a catfish skin-derived preparation rich in growth factors, in a T1D rat model to regenerate active β-cells. Sprague Dawley rats with T1D caused by streptozotocin injection received daily intraperitoneal injections of FB for 8 weeks. FB treatment significantly reduced blood glucose to a level close to that of normal control animals, increased serum insulin and C-peptide, and restored pancreatic insulin content. Histopathological and immunohistochemical analyses confirmed the regeneration of insulin-producing β-cells in pancreatic islets. FB treatment also improved diabetes-related health issues through a reduction in inflammation and oxidative stress, and an improvement in lipid profiles without toxicity or side effects. The regenerated β-cells remained functional for 48 weeks without the use of immunosuppressants, until the animals were sacrificed. These findings suggest FB treatment to be a promising procedure for translational research into T1D treatment.https://www.mdpi.com/2218-273X/15/7/929diabetescatfishFraction-Bβ-cellsstem cellslipids |
| spellingShingle | Jassim M. Al-Hassan Waleed M. Renno Sosamma Oommen Divya Nair Bincy Maniyalil Paul Bincy Mathew Jijin Kumar Afna Ummerkutty Cecil Pace-Asciak Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Injection of the Growth Factors-Rich Catfish Skin-Derived Fraction-B: An Introductory Report Biomolecules diabetes catfish Fraction-B β-cells stem cells lipids |
| title | Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Injection of the Growth Factors-Rich Catfish Skin-Derived Fraction-B: An Introductory Report |
| title_full | Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Injection of the Growth Factors-Rich Catfish Skin-Derived Fraction-B: An Introductory Report |
| title_fullStr | Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Injection of the Growth Factors-Rich Catfish Skin-Derived Fraction-B: An Introductory Report |
| title_full_unstemmed | Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Injection of the Growth Factors-Rich Catfish Skin-Derived Fraction-B: An Introductory Report |
| title_short | Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Injection of the Growth Factors-Rich Catfish Skin-Derived Fraction-B: An Introductory Report |
| title_sort | regeneration of insulin producing β cells reduction in inflammation and oxidation stress and improvement in lipid profile in a type 1 diabetes rat model by intraperitoneal injection of the growth factors rich catfish skin derived fraction b an introductory report |
| topic | diabetes catfish Fraction-B β-cells stem cells lipids |
| url | https://www.mdpi.com/2218-273X/15/7/929 |
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