Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci.

Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci.

Human ear morphology, a complex anatomical structure represented by a multidimensional set of correlated and heritable phenotypes, has a poorly understood genetic architecture. In this study, we quantitatively assessed 136 ear morphology traits using deep learning analysis of digital face images in...

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Main Authors: Yi Li, Ziyi Xiong, Manfei Zhang, Pirro G Hysi, Yu Qian, Kaustubh Adhikari, Jun Weng, Sijie Wu, Siyuan Du, Rolando Gonzalez-Jose, Lavinia Schuler-Faccini, Maria-Catira Bortolini, Victor Acuna-Alonzo, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Gabriel Bedoya, Francisco Rothhammer, Jiucun Wang, Jingze Tan, Ziyu Yuan, Li Jin, André G Uitterlinden, Mohsen Ghanbari, M Arfan Ikram, Tamar Nijsten, Xiangyu Zhu, Zhen Lei, Peilin Jia, Andres Ruiz-Linares, Timothy D Spector, Sijia Wang, Manfred Kayser, Fan Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-07-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010786&type=printable
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