Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional Status
Because ghrelin is one of the key hormones in regulating feeding behavior and caloric status, it was suggested that ghrelin behavior might be closely associated with malnutrition state of patients with chronic liver disease (CLD). Thus, we aimed to assess serum ghrelin levels in children with CLD an...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/560516 |
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| author | Z. A. Elkabbany R. T. Hamza N. H. Mahmoud |
| author_facet | Z. A. Elkabbany R. T. Hamza N. H. Mahmoud |
| author_sort | Z. A. Elkabbany |
| collection | DOAJ |
| description | Because ghrelin is one of the key hormones in regulating feeding behavior and caloric status, it was suggested that ghrelin behavior might be closely associated with malnutrition state of patients with chronic liver disease (CLD). Thus, we aimed to assess serum ghrelin levels in children with CLD and its relation to anthropometric parameters and severity of CLD. Forty CLD patients were studied in comparison to 40 controls. All subjects were subjected to history, anthropometric, and laboratory assessment of liver functions and serum acylated ghrelin. Ghrelin was higher in patients than controls being higher with progress of Child’s grade and with deterioration of liver functions. Hyperghrelinemia was detected in 62.5% of cases. Ghrelin correlated negatively with body mass index standard deviation score (BMISDS (r=-0.95, P<0.001)), triceps skin fold thickness (TSFT (r=-0.88, P<0.001)), and subscapular skin fold thickness (SSFT (r=0.83, P<0.001)) percentiles. In conclusion, hyperghrelinemia may represent a compensatory mechanism trying to overcome malnutrition state complicating CLD and can be used as a parameter for early detection and assessment of the severity of malnutrition in children with CLD. |
| format | Article |
| id | doaj-art-a2b4f3c586bd407588fcf20fe60ddd0d |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a2b4f3c586bd407588fcf20fe60ddd0d2025-08-20T03:38:44ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/560516560516Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional StatusZ. A. Elkabbany0R. T. Hamza1N. H. Mahmoud2Departments of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, EgyptDepartments of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, EgyptClinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, EgyptBecause ghrelin is one of the key hormones in regulating feeding behavior and caloric status, it was suggested that ghrelin behavior might be closely associated with malnutrition state of patients with chronic liver disease (CLD). Thus, we aimed to assess serum ghrelin levels in children with CLD and its relation to anthropometric parameters and severity of CLD. Forty CLD patients were studied in comparison to 40 controls. All subjects were subjected to history, anthropometric, and laboratory assessment of liver functions and serum acylated ghrelin. Ghrelin was higher in patients than controls being higher with progress of Child’s grade and with deterioration of liver functions. Hyperghrelinemia was detected in 62.5% of cases. Ghrelin correlated negatively with body mass index standard deviation score (BMISDS (r=-0.95, P<0.001)), triceps skin fold thickness (TSFT (r=-0.88, P<0.001)), and subscapular skin fold thickness (SSFT (r=0.83, P<0.001)) percentiles. In conclusion, hyperghrelinemia may represent a compensatory mechanism trying to overcome malnutrition state complicating CLD and can be used as a parameter for early detection and assessment of the severity of malnutrition in children with CLD.http://dx.doi.org/10.1155/2014/560516 |
| spellingShingle | Z. A. Elkabbany R. T. Hamza N. H. Mahmoud Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional Status The Scientific World Journal |
| title | Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional Status |
| title_full | Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional Status |
| title_fullStr | Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional Status |
| title_full_unstemmed | Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional Status |
| title_short | Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional Status |
| title_sort | assessment of serum acylated ghrelin in children and adolescents with chronic liver diseases relation to nutritional status |
| url | http://dx.doi.org/10.1155/2014/560516 |
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