Effects of BNT162b2 mRNA Covid-19 vaccine on vascular function.
The effects of Covid-19 vaccines on vascular function are still controversial. We evaluated the effects of BNT162b2 vaccine (BioNTech and Pfizer) on endothelial function assessed by flow-mediated vasodilation (FMD) and vascular smooth muscle function assessed by nitroglycerine-induced vasodilation (...
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0302512&type=printable |
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| author | Takayuki Yamaji Takahiro Harada Yu Hashimoto Yukiko Nakano Masato Kajikawa Kenichi Yoshimura Chikara Goto Yiming Han Aya Mizobuchi Farina Mohamad Yusoff Shinji Kishimoto Tatsuya Maruhashi Ayumu Nakashima Yukihito Higashi |
| author_facet | Takayuki Yamaji Takahiro Harada Yu Hashimoto Yukiko Nakano Masato Kajikawa Kenichi Yoshimura Chikara Goto Yiming Han Aya Mizobuchi Farina Mohamad Yusoff Shinji Kishimoto Tatsuya Maruhashi Ayumu Nakashima Yukihito Higashi |
| author_sort | Takayuki Yamaji |
| collection | DOAJ |
| description | The effects of Covid-19 vaccines on vascular function are still controversial. We evaluated the effects of BNT162b2 vaccine (BioNTech and Pfizer) on endothelial function assessed by flow-mediated vasodilation (FMD) and vascular smooth muscle function assessed by nitroglycerine-induced vasodilation (NID). This study was a prospective observational study. A total of 23 medical staff at Hiroshima University Hospital were enrolled in this study. FMD and NID were measured before vaccination and two weeks and six months after the 2nd dose of vaccination. FMD was significantly smaller two weeks after the 2nd dose of vaccination than before vaccination (6.5±2.4% and 8.2±2.6%, p = 0.03). FMD was significantly larger at six months than at two weeks after the 2nd dose of vaccination (8.2±3.0% and 6.5±2.4%, p = 0.03). There was no significant difference between FMD before vaccination and that at six months after the 2nd dose of vaccination (8.2±2.6% to 8.2±3.0%, p = 0.96). NID values were similar before vaccination and at two weeks, and six months after vaccination (p = 0.89). The BNT162b2 Covid-19 vaccine temporally impaired endothelial function but not vascular smooth muscle function, and the impaired endothelial function returned to the baseline level within six months after vaccination. |
| format | Article |
| id | doaj-art-a2ac3d2589874c81bc54bd765b75cb66 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-a2ac3d2589874c81bc54bd765b75cb662025-08-20T03:02:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01194e030251210.1371/journal.pone.0302512Effects of BNT162b2 mRNA Covid-19 vaccine on vascular function.Takayuki YamajiTakahiro HaradaYu HashimotoYukiko NakanoMasato KajikawaKenichi YoshimuraChikara GotoYiming HanAya MizobuchiFarina Mohamad YusoffShinji KishimotoTatsuya MaruhashiAyumu NakashimaYukihito HigashiThe effects of Covid-19 vaccines on vascular function are still controversial. We evaluated the effects of BNT162b2 vaccine (BioNTech and Pfizer) on endothelial function assessed by flow-mediated vasodilation (FMD) and vascular smooth muscle function assessed by nitroglycerine-induced vasodilation (NID). This study was a prospective observational study. A total of 23 medical staff at Hiroshima University Hospital were enrolled in this study. FMD and NID were measured before vaccination and two weeks and six months after the 2nd dose of vaccination. FMD was significantly smaller two weeks after the 2nd dose of vaccination than before vaccination (6.5±2.4% and 8.2±2.6%, p = 0.03). FMD was significantly larger at six months than at two weeks after the 2nd dose of vaccination (8.2±3.0% and 6.5±2.4%, p = 0.03). There was no significant difference between FMD before vaccination and that at six months after the 2nd dose of vaccination (8.2±2.6% to 8.2±3.0%, p = 0.96). NID values were similar before vaccination and at two weeks, and six months after vaccination (p = 0.89). The BNT162b2 Covid-19 vaccine temporally impaired endothelial function but not vascular smooth muscle function, and the impaired endothelial function returned to the baseline level within six months after vaccination.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0302512&type=printable |
| spellingShingle | Takayuki Yamaji Takahiro Harada Yu Hashimoto Yukiko Nakano Masato Kajikawa Kenichi Yoshimura Chikara Goto Yiming Han Aya Mizobuchi Farina Mohamad Yusoff Shinji Kishimoto Tatsuya Maruhashi Ayumu Nakashima Yukihito Higashi Effects of BNT162b2 mRNA Covid-19 vaccine on vascular function. PLoS ONE |
| title | Effects of BNT162b2 mRNA Covid-19 vaccine on vascular function. |
| title_full | Effects of BNT162b2 mRNA Covid-19 vaccine on vascular function. |
| title_fullStr | Effects of BNT162b2 mRNA Covid-19 vaccine on vascular function. |
| title_full_unstemmed | Effects of BNT162b2 mRNA Covid-19 vaccine on vascular function. |
| title_short | Effects of BNT162b2 mRNA Covid-19 vaccine on vascular function. |
| title_sort | effects of bnt162b2 mrna covid 19 vaccine on vascular function |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0302512&type=printable |
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