Oxyresveratrol enhances hair regeneration in human dermal papilla cell and androgenetic alopecia mouse model
Abstract Alopecia, or hair loss, is a common dermatological condition caused by multiple factors. Oxyresveratrol (ORV), a compound derived from the heartwood of Artocarpus lakoocha, is recognized for its potent antioxidant properties, with recent studies highlighting its anti-inflammatory effect acr...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-02581-z |
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| author | Hung Gia Tran Aussavashai Shuayprom Alisa Ruchusatsawat Kornvalee Meesilpavikkai Virgil A. S. H. Dalm Kriangsak Ruchusatsawat Jongkonnee Wongpiyabovorn |
| author_facet | Hung Gia Tran Aussavashai Shuayprom Alisa Ruchusatsawat Kornvalee Meesilpavikkai Virgil A. S. H. Dalm Kriangsak Ruchusatsawat Jongkonnee Wongpiyabovorn |
| author_sort | Hung Gia Tran |
| collection | DOAJ |
| description | Abstract Alopecia, or hair loss, is a common dermatological condition caused by multiple factors. Oxyresveratrol (ORV), a compound derived from the heartwood of Artocarpus lakoocha, is recognized for its potent antioxidant properties, with recent studies highlighting its anti-inflammatory effect across various cell types. This study aims to explore the therapeutic potential of ORV in treating alopecia. We evaluated the effects of ORV on Human Follicle Dermal Papilla Cells (HFDPCs) and an androgenetic alopecia (AGA) mouse model. Oxidative stress in HFDPCs was induced using hydrogen peroxide (H2O2), and dihydrotestosterone (DHT) was used to simulate AGA in both HFDPCs and C57BL/6NJcl mice. Our finding demonstrated that ORV significantly enhanced HFDPCs proliferation. In H2O2-induced oxidative stress conditions, pretreatment with ORV decreased reactive oxygen species (ROS) levels and reduced the production of pro-inflammatory cytokine. In the AGA model, ORV inhibited β-Catenin phosphorylation in HFDPCs, thereby promoting hair growth and maintaining skin thickness, hair bulb size, and count in mice. Overall, ORV demonstrated anti-inflammatory and hair-regenerative effects in both in vitro and in vivo models of alopecia. These findings suggest that ORV is a promising candidate for the treatment of hair loss. |
| format | Article |
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| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-a2aab9c8a5d047c5b5e0d6afabb3e66a2025-08-20T01:53:12ZengNature PortfolioScientific Reports2045-23222025-05-0115111310.1038/s41598-025-02581-zOxyresveratrol enhances hair regeneration in human dermal papilla cell and androgenetic alopecia mouse modelHung Gia Tran0Aussavashai Shuayprom1Alisa Ruchusatsawat2Kornvalee Meesilpavikkai3Virgil A. S. H. Dalm4Kriangsak Ruchusatsawat5Jongkonnee Wongpiyabovorn6Center of Excellence in Immune-Mediated Diseases, Division of Immunology, Department of Microbiology, Faculty of Medicine, Chulalongkorn UniversityRegional Medical Sciences Center 3 Nakhonsawan, Department of Medical Sciences, Ministry of Public HealthEngineering Science Classroom, King Mongkut’s University of TechnologyDepartment of Microbiology, Faculty of Medicine, Chulalongkorn UniversityDepartment of Immunology, Laboratory Medical Immunology, Erasmus University Medical CenterMedical Sciences Technical Office, Department of Medical Sciences, Ministry of Public HealthCenter of Excellence in Immune-Mediated Diseases, Division of Immunology, Department of Microbiology, Faculty of Medicine, Chulalongkorn UniversityAbstract Alopecia, or hair loss, is a common dermatological condition caused by multiple factors. Oxyresveratrol (ORV), a compound derived from the heartwood of Artocarpus lakoocha, is recognized for its potent antioxidant properties, with recent studies highlighting its anti-inflammatory effect across various cell types. This study aims to explore the therapeutic potential of ORV in treating alopecia. We evaluated the effects of ORV on Human Follicle Dermal Papilla Cells (HFDPCs) and an androgenetic alopecia (AGA) mouse model. Oxidative stress in HFDPCs was induced using hydrogen peroxide (H2O2), and dihydrotestosterone (DHT) was used to simulate AGA in both HFDPCs and C57BL/6NJcl mice. Our finding demonstrated that ORV significantly enhanced HFDPCs proliferation. In H2O2-induced oxidative stress conditions, pretreatment with ORV decreased reactive oxygen species (ROS) levels and reduced the production of pro-inflammatory cytokine. In the AGA model, ORV inhibited β-Catenin phosphorylation in HFDPCs, thereby promoting hair growth and maintaining skin thickness, hair bulb size, and count in mice. Overall, ORV demonstrated anti-inflammatory and hair-regenerative effects in both in vitro and in vivo models of alopecia. These findings suggest that ORV is a promising candidate for the treatment of hair loss.https://doi.org/10.1038/s41598-025-02581-zAlopeciaAnti-inflammationHair regenerationDihydrotestosteroneOxyresveratrol |
| spellingShingle | Hung Gia Tran Aussavashai Shuayprom Alisa Ruchusatsawat Kornvalee Meesilpavikkai Virgil A. S. H. Dalm Kriangsak Ruchusatsawat Jongkonnee Wongpiyabovorn Oxyresveratrol enhances hair regeneration in human dermal papilla cell and androgenetic alopecia mouse model Scientific Reports Alopecia Anti-inflammation Hair regeneration Dihydrotestosterone Oxyresveratrol |
| title | Oxyresveratrol enhances hair regeneration in human dermal papilla cell and androgenetic alopecia mouse model |
| title_full | Oxyresveratrol enhances hair regeneration in human dermal papilla cell and androgenetic alopecia mouse model |
| title_fullStr | Oxyresveratrol enhances hair regeneration in human dermal papilla cell and androgenetic alopecia mouse model |
| title_full_unstemmed | Oxyresveratrol enhances hair regeneration in human dermal papilla cell and androgenetic alopecia mouse model |
| title_short | Oxyresveratrol enhances hair regeneration in human dermal papilla cell and androgenetic alopecia mouse model |
| title_sort | oxyresveratrol enhances hair regeneration in human dermal papilla cell and androgenetic alopecia mouse model |
| topic | Alopecia Anti-inflammation Hair regeneration Dihydrotestosterone Oxyresveratrol |
| url | https://doi.org/10.1038/s41598-025-02581-z |
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