Exploring PTPN6 as a dual oncogenic and immunological marker in melanoma
Abstract Melanoma is an aggressive form of skin cancer known for its ability to avoid detection by the immune system and resist treatment. This study explores the role of PTPN6, a protein linked to lactate, as both an oncogene and an immune-related biomarker in melanoma. Using computational tools, w...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-03038-5 |
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| author | Piaopiao Bian Shaoyan Liu Qiuping Luo Zewen Feng Sanyan Li Wei Zhang |
| author_facet | Piaopiao Bian Shaoyan Liu Qiuping Luo Zewen Feng Sanyan Li Wei Zhang |
| author_sort | Piaopiao Bian |
| collection | DOAJ |
| description | Abstract Melanoma is an aggressive form of skin cancer known for its ability to avoid detection by the immune system and resist treatment. This study explores the role of PTPN6, a protein linked to lactate, as both an oncogene and an immune-related biomarker in melanoma. Using computational tools, we examined the expression and mutation patterns of lactate-related genes in skin cutaneous melanoma (SKCM) and identified different patient groups based on prognosis. Our results show that PTPN6 plays a key role in regulating immune responses, affecting the behavior of immune cells. This suggests that PTPN6 could be a promising target for new therapies. By combining insights from metabolism and immunology, our research lays the groundwork for personalized treatments that may improve outcomes for melanoma patients. |
| format | Article |
| id | doaj-art-a2a37fe0bc7844aba954400d59c125f9 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-a2a37fe0bc7844aba954400d59c125f92025-08-20T04:01:34ZengSpringerDiscover Oncology2730-60112025-07-0116111210.1007/s12672-025-03038-5Exploring PTPN6 as a dual oncogenic and immunological marker in melanomaPiaopiao Bian0Shaoyan Liu1Qiuping Luo2Zewen Feng3Sanyan Li4Wei Zhang5Department of Pathology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Pathology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Pathology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Pathology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Pathology, Qianjiang Central HospitalDepartment of Pathology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical UniversityAbstract Melanoma is an aggressive form of skin cancer known for its ability to avoid detection by the immune system and resist treatment. This study explores the role of PTPN6, a protein linked to lactate, as both an oncogene and an immune-related biomarker in melanoma. Using computational tools, we examined the expression and mutation patterns of lactate-related genes in skin cutaneous melanoma (SKCM) and identified different patient groups based on prognosis. Our results show that PTPN6 plays a key role in regulating immune responses, affecting the behavior of immune cells. This suggests that PTPN6 could be a promising target for new therapies. By combining insights from metabolism and immunology, our research lays the groundwork for personalized treatments that may improve outcomes for melanoma patients.https://doi.org/10.1007/s12672-025-03038-5MelanomaPTPN6PrognosisImmunogenicBiomarker |
| spellingShingle | Piaopiao Bian Shaoyan Liu Qiuping Luo Zewen Feng Sanyan Li Wei Zhang Exploring PTPN6 as a dual oncogenic and immunological marker in melanoma Discover Oncology Melanoma PTPN6 Prognosis Immunogenic Biomarker |
| title | Exploring PTPN6 as a dual oncogenic and immunological marker in melanoma |
| title_full | Exploring PTPN6 as a dual oncogenic and immunological marker in melanoma |
| title_fullStr | Exploring PTPN6 as a dual oncogenic and immunological marker in melanoma |
| title_full_unstemmed | Exploring PTPN6 as a dual oncogenic and immunological marker in melanoma |
| title_short | Exploring PTPN6 as a dual oncogenic and immunological marker in melanoma |
| title_sort | exploring ptpn6 as a dual oncogenic and immunological marker in melanoma |
| topic | Melanoma PTPN6 Prognosis Immunogenic Biomarker |
| url | https://doi.org/10.1007/s12672-025-03038-5 |
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