Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis
Background: Neonicotinoids (NEOs) are well-designed highly selective pesticides that target nicotinic acetylcholine receptors. However, their extensive use, accumulation, and biomagnification pose significant risks to humans. Increasing evidence has suggested that NEOs may affect glucose homeostasis...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324016725 |
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| author | Wenwen Zhu Jiali Fang Chenbo Ji Hong Zhong Tianying Zhong Xianwei Cui |
| author_facet | Wenwen Zhu Jiali Fang Chenbo Ji Hong Zhong Tianying Zhong Xianwei Cui |
| author_sort | Wenwen Zhu |
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| description | Background: Neonicotinoids (NEOs) are well-designed highly selective pesticides that target nicotinic acetylcholine receptors. However, their extensive use, accumulation, and biomagnification pose significant risks to humans. Increasing evidence has suggested that NEOs may affect glucose homeostasis, but little research has linked NEOs exposure to gestational diabetes mellitus (GDM), which is the most common disease in pregnancy. We here aimed to investigate the association between NEOs exposure and GDM occurrence. Methods: 100 pregnant women who completed a 75 g oral glucose tolerance test (OGTT) at 24–28 weeks of gestation were enrolled. Urinary concentrations of seven widely used NEOs were quantified using ultra-high performance liquid chromatography multiple reaction monitoring mass spectrometry (UHPLC-MRM-MS/MS). Correlation analysis revealed the associations between NEOs concentrations and glucose homeostasis parameters. The toxic effects of thiamethoxam (TMX) and clothianidin (CLO) were assessed using pregnant mice, and the potential mechanism in impairing glucose disposition regarding brown adipose tissue (BAT) thermogenesis has been elucidated. Results: Among the 100 urine samples, 88 % were contaminated by NEOs with concentrations ranging from 2.50 to 491.34 nmol/L. TMX and CLO were the most frequently detected NEOs, highly detected in women with GDM. Moreover, we found statistically significant associations between TMX concentrations and 1hBG, and 2hBG. Exposure to mixed NEOs during gestation resulted in elevated glucose levels and impaired insulin sensitivity in normal pregnant and GDM mice models. In addition, we found the metabolic disorders induced by NEOs were linked to the deterioration of BAT thermogenesis in vivo. Conclusion: In general, we demonstrated that prenatal exposures to NEOs were associated with an increased risk of GDM by deteriorating the thermogenic capacity of BAT |
| format | Article |
| id | doaj-art-a2a14de76b214294992731913c6b33e6 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-a2a14de76b214294992731913c6b33e62025-02-12T05:29:55ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117596Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesisWenwen Zhu0Jiali Fang1Chenbo Ji2Hong Zhong3Tianying Zhong4Xianwei Cui5Nanjing Women and Children’s Healthcare Institute, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, ChinaNanjing Women and Children’s Healthcare Institute, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, ChinaNanjing Women and Children’s Healthcare Institute, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, ChinaCorrespondence to: Nanjing Women and Children’s Healthcare Institute, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, 123 Tianfei Alley, Mochou Road, Nanjing, Jiangsu 210004, China.; Nanjing Women and Children’s Healthcare Institute, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, ChinaCorrespondence to: Nanjing Women and Children’s Healthcare Institute, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, 123 Tianfei Alley, Mochou Road, Nanjing, Jiangsu 210004, China.; Nanjing Women and Children’s Healthcare Institute, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, ChinaCorrespondence to: Nanjing Women and Children’s Healthcare Institute, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, 123 Tianfei Alley, Mochou Road, Nanjing, Jiangsu 210004, China.; Nanjing Women and Children’s Healthcare Institute, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing, ChinaBackground: Neonicotinoids (NEOs) are well-designed highly selective pesticides that target nicotinic acetylcholine receptors. However, their extensive use, accumulation, and biomagnification pose significant risks to humans. Increasing evidence has suggested that NEOs may affect glucose homeostasis, but little research has linked NEOs exposure to gestational diabetes mellitus (GDM), which is the most common disease in pregnancy. We here aimed to investigate the association between NEOs exposure and GDM occurrence. Methods: 100 pregnant women who completed a 75 g oral glucose tolerance test (OGTT) at 24–28 weeks of gestation were enrolled. Urinary concentrations of seven widely used NEOs were quantified using ultra-high performance liquid chromatography multiple reaction monitoring mass spectrometry (UHPLC-MRM-MS/MS). Correlation analysis revealed the associations between NEOs concentrations and glucose homeostasis parameters. The toxic effects of thiamethoxam (TMX) and clothianidin (CLO) were assessed using pregnant mice, and the potential mechanism in impairing glucose disposition regarding brown adipose tissue (BAT) thermogenesis has been elucidated. Results: Among the 100 urine samples, 88 % were contaminated by NEOs with concentrations ranging from 2.50 to 491.34 nmol/L. TMX and CLO were the most frequently detected NEOs, highly detected in women with GDM. Moreover, we found statistically significant associations between TMX concentrations and 1hBG, and 2hBG. Exposure to mixed NEOs during gestation resulted in elevated glucose levels and impaired insulin sensitivity in normal pregnant and GDM mice models. In addition, we found the metabolic disorders induced by NEOs were linked to the deterioration of BAT thermogenesis in vivo. Conclusion: In general, we demonstrated that prenatal exposures to NEOs were associated with an increased risk of GDM by deteriorating the thermogenic capacity of BAThttp://www.sciencedirect.com/science/article/pii/S0147651324016725NeonicotinoidsGestational diabetes mellitusGlucose metabolismBrown adipose tissueThermogenesis |
| spellingShingle | Wenwen Zhu Jiali Fang Chenbo Ji Hong Zhong Tianying Zhong Xianwei Cui Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis Ecotoxicology and Environmental Safety Neonicotinoids Gestational diabetes mellitus Glucose metabolism Brown adipose tissue Thermogenesis |
| title | Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis |
| title_full | Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis |
| title_fullStr | Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis |
| title_full_unstemmed | Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis |
| title_short | Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis |
| title_sort | maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis |
| topic | Neonicotinoids Gestational diabetes mellitus Glucose metabolism Brown adipose tissue Thermogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324016725 |
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