Potassium-competitive Acid Blockers: A New Therapeutic Strategy for Helicobacter pylori Eradication
The escalating prevalence of clarithromycin resistance in cases of Helicobacter pylori, insufficient acid suppression, and pharmacodynamic variations secondary to inter-individual differences in CYP2C19 polymorphism collectively contribute to suboptimal eradication rates observed with proton pump in...
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| Format: | Article |
| Language: | English |
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Korean College of Helicobacter and Upper Gastrointestinal Research
2023-09-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
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| Online Access: | http://www.helicojournal.org/upload/pdf/kjhugr-2023-0041.pdf |
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| author | Byeong Yun Ahn Soo-Jeong Cho |
| author_facet | Byeong Yun Ahn Soo-Jeong Cho |
| author_sort | Byeong Yun Ahn |
| collection | DOAJ |
| description | The escalating prevalence of clarithromycin resistance in cases of Helicobacter pylori, insufficient acid suppression, and pharmacodynamic variations secondary to inter-individual differences in CYP2C19 polymorphism collectively contribute to suboptimal eradication rates observed with proton pump inhibitor (PPI)-based therapy. Compared with PPIs, potassium-competitive acid blockers (PCABs) produce rapid, potent, and long-lasting suppression of gastric acid through reversible inhibition of gastric H+, K+-ATPase. PCAB-based therapy results in significant inhibition of acid secretion and has therefore emerged as a novel and effective approach for H. pylori eradication. In this study, we review the efficacy and safety profile of PCAB-based eradication regimens comprising vonoprazan, tegoprazan, and fexuprazan. |
| format | Article |
| id | doaj-art-a29f4f1171df4405b9652e7f8ffc7e4a |
| institution | Kabale University |
| issn | 1738-3331 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-a29f4f1171df4405b9652e7f8ffc7e4a2025-08-20T03:35:50ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312023-09-0123317417910.7704/kjhugr.2023.0041790Potassium-competitive Acid Blockers: A New Therapeutic Strategy for Helicobacter pylori EradicationByeong Yun Ahn0Soo-Jeong Cho1Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, KoreaThe escalating prevalence of clarithromycin resistance in cases of Helicobacter pylori, insufficient acid suppression, and pharmacodynamic variations secondary to inter-individual differences in CYP2C19 polymorphism collectively contribute to suboptimal eradication rates observed with proton pump inhibitor (PPI)-based therapy. Compared with PPIs, potassium-competitive acid blockers (PCABs) produce rapid, potent, and long-lasting suppression of gastric acid through reversible inhibition of gastric H+, K+-ATPase. PCAB-based therapy results in significant inhibition of acid secretion and has therefore emerged as a novel and effective approach for H. pylori eradication. In this study, we review the efficacy and safety profile of PCAB-based eradication regimens comprising vonoprazan, tegoprazan, and fexuprazan.http://www.helicojournal.org/upload/pdf/kjhugr-2023-0041.pdfdrug resistance, microbialdrug therapygastric acid proton pump inhibitors |
| spellingShingle | Byeong Yun Ahn Soo-Jeong Cho Potassium-competitive Acid Blockers: A New Therapeutic Strategy for Helicobacter pylori Eradication The Korean Journal of Helicobacter and Upper Gastrointestinal Research drug resistance, microbial drug therapy gastric acid proton pump inhibitors |
| title | Potassium-competitive Acid Blockers: A New Therapeutic Strategy for Helicobacter pylori Eradication |
| title_full | Potassium-competitive Acid Blockers: A New Therapeutic Strategy for Helicobacter pylori Eradication |
| title_fullStr | Potassium-competitive Acid Blockers: A New Therapeutic Strategy for Helicobacter pylori Eradication |
| title_full_unstemmed | Potassium-competitive Acid Blockers: A New Therapeutic Strategy for Helicobacter pylori Eradication |
| title_short | Potassium-competitive Acid Blockers: A New Therapeutic Strategy for Helicobacter pylori Eradication |
| title_sort | potassium competitive acid blockers a new therapeutic strategy for helicobacter pylori eradication |
| topic | drug resistance, microbial drug therapy gastric acid proton pump inhibitors |
| url | http://www.helicojournal.org/upload/pdf/kjhugr-2023-0041.pdf |
| work_keys_str_mv | AT byeongyunahn potassiumcompetitiveacidblockersanewtherapeuticstrategyforhelicobacterpylorieradication AT soojeongcho potassiumcompetitiveacidblockersanewtherapeuticstrategyforhelicobacterpylorieradication |