Islet organoids: a new hope for islet transplantation in diabetes

Islet organoids: a new hope for islet transplantation in diabetes

Diabetes mellitus, including Type 1 diabetes (T1D) and advanced Type 2 diabetes (T2D), remains a major global health challenge due to the destruction or dysfunction of insulin-producing β-cells. Islet transplantation offers a promising therapeutic strategy. However, it is limited by organ shortage g...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xuemei Yu, Chengkong Liu, Zheng Kuang, Siyuan Song, Limin Tian, Yi Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Immunology
Subjects:	islet organoids diabetes treatment Procr+ progenitors chemically induced pluripotent stem cells (CiPSCs) endoderm stem cells (EnSCs) β-cell regeneration
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1540209/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Innovations in intestinal organoid technology featuring an open apical surface
by: Ye Chen, et al.
Published: (2025-06-01)

Multitasking muscle: engineering iPSC-derived myogenic progenitors to do more
by: Mark Stephen Hamer, et al.
Published: (2025-01-01)

Patient-derived cornea organoid model to study metabolomic characterization of rare disease: aniridia-associated keratopathy
by: Ali Can Koc, et al.
Published: (2025-01-01)

Neuroligin-3 R451C induces gain-of-function gene expression in astroglia in an astroglia-enriched brain organoid model
by: Rui Dang, et al.
Published: (2025-01-01)

Research advances in the construction of stem cell-derived ovarian organoids
by: Tianyue Zhang, et al.
Published: (2024-12-01)

Protocol for generating a pancreatic cancer organoid associated with heterogeneous tumor microenvironment
by: Kenta Takeuchi, et al.
Published: (2025-03-01)

Pluripotent stem cells from the perspective of developmental potential and their characteristics
by: In-Won Lee, et al.
Published: (2024-12-01)

The necessity of cell banks
by: A. G. Menzorov, et al.
Published: (2017-02-01)

Stem Cell Therapy for the Treatment of Amyotrophic Lateral Sclerosis: Comparison of the Efficacy of Mesenchymal Stem Cells, Neural Stem Cells, and Induced Pluripotent Stem Cells
by: Lauren Frawley, et al.
Published: (2024-12-01)

Duodenal Organoids From Metabolic Dysfunction-Associated Steatohepatitis Patients Exhibit Absorptive and Barrier Alterations
by: Alia Hadefi, et al.
Published: (2025-01-01)

Transcriptomic and Functional Landscape of Adult Human Spinal Cord NSPCs Compared to iPSC-Derived Neural Progenitor Cells
by: Sasi Kumar Jagadeesan, et al.
Published: (2025-01-01)

The Critical Role of YAP/BMP/ID1 Axis on Simulated Microgravity‐Induced Neural Tube Defects in Human Brain Organoids
by: Di Guo, et al.
Published: (2025-02-01)

Constructing a potential HLA haplo-homozygous induced pluripotent stem cell haplobank using data from an umbilical cord blood bank
by: Ji He, et al.
Published: (2025-02-01)

MOUSE AND HUMAN EMBRYONIC STEM CELLS
by: A. G. Menzorov
Published: (2014-12-01)

Protocol for generating human assembloids to investigate thalamocortical and corticothalamic synaptic transmission and plasticity
by: Anjana Nityanandam, et al.
Published: (2025-03-01)

Induced pluripotent stem cell–related approaches to generate dopaminergic neurons for Parkinson’s disease
by: Ling-Xiao Yi, et al.
Published: (2025-11-01)

Stem Cell Therapy for Diseases of Livestock Animals: An In-Depth Review
by: Raghavendra B. Narasimha, et al.
Published: (2025-01-01)

Advances in liver organoids: replicating hepatic complexity for toxicity assessment and disease modeling
by: Weidong Shao, et al.
Published: (2025-01-01)

Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington’s disease phenotypes
by: Danielle A. Simmons, et al.
Published: (2025-03-01)

Hepatobiliary organoid research: the progress and applications
by: Rui-Qi Zou, et al.
Published: (2025-02-01)

Induced mesenchymal stem cells generated from periodontal ligament fibroblast for regenerative therapy
by: Hemanathan Vembuli, et al.
Published: (2025-02-01)

Bi-Hormonal Endocrine Cell Presence Within the Islets of Langerhans of the Human Pancreas Throughout Life
by: Jiwon Hahm, et al.
Published: (2025-01-01)

Protocol for differentiating cardiomyocytes and generating engineered heart tissues from human feeder-free extended pluripotent stem cells
by: Zhongjun Wan, et al.
Published: (2025-03-01)

The role of KLF4 in human primordial germ cell development
by: Sun-Min Lee, et al.
Published: (2025-01-01)

Efficient chimeric mouse production using a novel embryonic stem cell line
by: G. V. Kontsevaya, et al.
Published: (2017-02-01)

BRD8 Guards the Pluripotent State by Sensing and Maintaining Histone Acetylation
by: Li Sun, et al.
Published: (2025-02-01)

A systematic review of progenitor survival and maturation in Parkinsonian models
by: Giulia Comini, et al.
Published: (2025-11-01)

Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance
by: Tianming Qiu, et al.
Published: (2025-01-01)

Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity
by: Matthew C. Austin, et al.
Published: (2025-01-01)

Bioinformatic Prediction of Novel microRNAs Encoded in Krüppel-like Factor 4 Gene
by: Mina Zahiri, et al.
Published: (2024-02-01)

Stem Cells: Innovations, Applications, and Future Directions
by: Tejaspreet Kaur, et al.
Published: (2024-12-01)

Phase-dependent iron depletion differentially regulates the niche of intestinal stem cells in experimental colitis via ERK/STAT3 signaling pathway
by: Shubin Wang, et al.
Published: (2025-01-01)

The differentiation state of small intestinal organoid models influences prediction of drug-induced toxicity
by: Jessica A. Klein, et al.
Published: (2025-01-01)

Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy
by: Xingren Liu, et al.
Published: (2025-01-01)

Review: Livestock cell types with myogenic differentiation potential: Considerations for the development of cultured meat
by: M. Olenic, et al.
Published: (2025-02-01)

The Rise of Pluripotent Stem Cell-Derived Glia Models of Neuroinflammation
by: Srishti Kala, et al.
Published: (2025-01-01)

Sporadic ALS hiPSC-derived motor neurons show axonal defects linked to altered axon guidance pathways
by: Lisha Ye, et al.
Published: (2025-03-01)

From Serendipity to Precision: Integrating AI, Multi-Omics, and Human-Specific Models for Personalized Neuropsychiatric Care
by: Masaru Tanaka
Published: (2025-01-01)

Comparison of human-induced pluripotent stem cell-derived macrophages with peripheral blood-derived macrophages using single-cell genomics
by: ZHANG Yutong, et al.
Published: (2024-12-01)

Cylindroma Mimicking Neurofibroma
by: Vinod Kumar Gonuru, et al.
Published: (2023-09-01)