Impact of liver graft steatosis on long-term post-transplant hepatic steatosis and fibrosis via magnetic resonance quantification
BackgroundThe rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has led to an increased occurrence of steatotic liver grafts (SLG) in liver transplantation (LT). However, the implications of SLG on post-transplant de novo hepatic steatosis (PTHS) and advanced fibr...
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Frontiers Media S.A.
2025-01-01
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| author | Lung-Yi Mak Lung-Yi Mak James Fung James Fung James Fung James Fung Gladys Lo Christine Shing-Yen Lo Trevor Kwan-Hung Wu Matthew Shing-Hin Chung Tiffany Cho-Lam Wong Tiffany Cho-Lam Wong Wai-Kay Seto Wai-Kay Seto Albert Chi-Yan Chan Albert Chi-Yan Chan Man-Fung Yuen Man-Fung Yuen |
| author_facet | Lung-Yi Mak Lung-Yi Mak James Fung James Fung James Fung James Fung Gladys Lo Christine Shing-Yen Lo Trevor Kwan-Hung Wu Matthew Shing-Hin Chung Tiffany Cho-Lam Wong Tiffany Cho-Lam Wong Wai-Kay Seto Wai-Kay Seto Albert Chi-Yan Chan Albert Chi-Yan Chan Man-Fung Yuen Man-Fung Yuen |
| author_sort | Lung-Yi Mak |
| collection | DOAJ |
| description | BackgroundThe rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has led to an increased occurrence of steatotic liver grafts (SLG) in liver transplantation (LT). However, the implications of SLG on post-transplant de novo hepatic steatosis (PTHS) and advanced fibrosis (≥F3) remain uncertain. This study aimed to characterize PTHS and ≥ F3 using magnetic resonance imaging (MRI) in patients who underwent LT for non-MASLD indications and to examine their relationship with SLG.MethodsPost-LT patients with implant biopsy fat content data were recruited for MRI assessments. MRI-proton density fat fraction (MRI-PDFF) and MR elastography (MRE) were performed using a 1.5 Tesla Optima 450 W MR scanner with a 3D volumetric sequence. PTHS and ≥ F3 were defined as MRI-PDFF ≥5% and MRE ≥3.64 kPa, respectively. SLG was defined as implant biopsy fat content ≥5%.ResultsA total of 292 patients (70.5% men, median age at LT: 51.9 years, 22.6% with SLG) were recruited. The majority (73.6%) were transplanted for hepatitis B virus (HBV)-related complications. MRI performed at a median of 12.2 years post-LT identified PTHS in 27.4 and 10.6% of patients. PTHS was independently associated with SLG (OR 2.067, 95% CI 1.082–3.951), central obesity (OR 3.952, 95% CI 1.768–8.832), and hypertension (OR 2.510, 95% CI 1.268–4.966). In contrast, ≥F3 was associated with sex, change in BMI, and abnormal liver biochemistry but not with PTHS or SLG.ConclusionMRI identified a high prevalence of PTHS, which was associated with SLG and metabolic risk factors among Chinese patients transplanted for non-MASLD indications. Advanced graft fibrosis was not associated with PTHS or SLG. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-a299533acdcd4ef2b6e40e14279b34542025-01-17T06:50:41ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15020551502055Impact of liver graft steatosis on long-term post-transplant hepatic steatosis and fibrosis via magnetic resonance quantificationLung-Yi Mak0Lung-Yi Mak1James Fung2James Fung3James Fung4James Fung5Gladys Lo6Christine Shing-Yen Lo7Trevor Kwan-Hung Wu8Matthew Shing-Hin Chung9Tiffany Cho-Lam Wong10Tiffany Cho-Lam Wong11Wai-Kay Seto12Wai-Kay Seto13Albert Chi-Yan Chan14Albert Chi-Yan Chan15Man-Fung Yuen16Man-Fung Yuen17Department of Medicine, School of Clinical Medicine, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaState Key Laboratory of Liver Research, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaDepartment of Medicine, School of Clinical Medicine, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaState Key Laboratory of Liver Research, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaDepartment of Surgery, School of Clinical Medicine, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaLiver Transplantation Unit, Queen Mary Hospital, Hong Kong SAR, ChinaDepartment of Diagnostic and Interventional Radiology, Hong Kong Sanatorium and Hospital, Hong Kong SAR, ChinaDepartment of Diagnostic and Interventional Radiology, Hong Kong Sanatorium and Hospital, Hong Kong SAR, ChinaDepartment of Medicine, School of Clinical Medicine, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaDepartment of Medicine, School of Clinical Medicine, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaDepartment of Surgery, School of Clinical Medicine, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaLiver Transplantation Unit, Queen Mary Hospital, Hong Kong SAR, ChinaDepartment of Medicine, School of Clinical Medicine, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaState Key Laboratory of Liver Research, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaDepartment of Surgery, School of Clinical Medicine, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaLiver Transplantation Unit, Queen Mary Hospital, Hong Kong SAR, ChinaDepartment of Medicine, School of Clinical Medicine, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaState Key Laboratory of Liver Research, The LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaBackgroundThe rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has led to an increased occurrence of steatotic liver grafts (SLG) in liver transplantation (LT). However, the implications of SLG on post-transplant de novo hepatic steatosis (PTHS) and advanced fibrosis (≥F3) remain uncertain. This study aimed to characterize PTHS and ≥ F3 using magnetic resonance imaging (MRI) in patients who underwent LT for non-MASLD indications and to examine their relationship with SLG.MethodsPost-LT patients with implant biopsy fat content data were recruited for MRI assessments. MRI-proton density fat fraction (MRI-PDFF) and MR elastography (MRE) were performed using a 1.5 Tesla Optima 450 W MR scanner with a 3D volumetric sequence. PTHS and ≥ F3 were defined as MRI-PDFF ≥5% and MRE ≥3.64 kPa, respectively. SLG was defined as implant biopsy fat content ≥5%.ResultsA total of 292 patients (70.5% men, median age at LT: 51.9 years, 22.6% with SLG) were recruited. The majority (73.6%) were transplanted for hepatitis B virus (HBV)-related complications. MRI performed at a median of 12.2 years post-LT identified PTHS in 27.4 and 10.6% of patients. PTHS was independently associated with SLG (OR 2.067, 95% CI 1.082–3.951), central obesity (OR 3.952, 95% CI 1.768–8.832), and hypertension (OR 2.510, 95% CI 1.268–4.966). In contrast, ≥F3 was associated with sex, change in BMI, and abnormal liver biochemistry but not with PTHS or SLG.ConclusionMRI identified a high prevalence of PTHS, which was associated with SLG and metabolic risk factors among Chinese patients transplanted for non-MASLD indications. Advanced graft fibrosis was not associated with PTHS or SLG.https://www.frontiersin.org/articles/10.3389/fmed.2024.1502055/fullMASLDliver transplantmetabolic dysfunctionimplant biopsyorgan donationsteatotic graft |
| spellingShingle | Lung-Yi Mak Lung-Yi Mak James Fung James Fung James Fung James Fung Gladys Lo Christine Shing-Yen Lo Trevor Kwan-Hung Wu Matthew Shing-Hin Chung Tiffany Cho-Lam Wong Tiffany Cho-Lam Wong Wai-Kay Seto Wai-Kay Seto Albert Chi-Yan Chan Albert Chi-Yan Chan Man-Fung Yuen Man-Fung Yuen Impact of liver graft steatosis on long-term post-transplant hepatic steatosis and fibrosis via magnetic resonance quantification Frontiers in Medicine MASLD liver transplant metabolic dysfunction implant biopsy organ donation steatotic graft |
| title | Impact of liver graft steatosis on long-term post-transplant hepatic steatosis and fibrosis via magnetic resonance quantification |
| title_full | Impact of liver graft steatosis on long-term post-transplant hepatic steatosis and fibrosis via magnetic resonance quantification |
| title_fullStr | Impact of liver graft steatosis on long-term post-transplant hepatic steatosis and fibrosis via magnetic resonance quantification |
| title_full_unstemmed | Impact of liver graft steatosis on long-term post-transplant hepatic steatosis and fibrosis via magnetic resonance quantification |
| title_short | Impact of liver graft steatosis on long-term post-transplant hepatic steatosis and fibrosis via magnetic resonance quantification |
| title_sort | impact of liver graft steatosis on long term post transplant hepatic steatosis and fibrosis via magnetic resonance quantification |
| topic | MASLD liver transplant metabolic dysfunction implant biopsy organ donation steatotic graft |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1502055/full |
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