Hemophagocytic Lymphohistiocytosis Complicating Erythroleukemia in a Child with Monosomy 7: A Case Report and Review of the Literature
Herein, the first case of childhood erythrophagocytosis following chemotherapy for erythroleukemia in a child with monosomy 7 is reported. A 5-year-old boy presented with anemia, thrombocytopenia, and hepatosplenomegaly in whom erythroleukemia was diagnosed. Prolonged pancytopenia accompanied by per...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/581073 |
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| author | Samin Alavi Maryam Ebadi Alireza Jenabzadeh M. T. Arzanian Sh. Shamsian |
| author_facet | Samin Alavi Maryam Ebadi Alireza Jenabzadeh M. T. Arzanian Sh. Shamsian |
| author_sort | Samin Alavi |
| collection | DOAJ |
| description | Herein, the first case of childhood erythrophagocytosis following chemotherapy for erythroleukemia in a child with monosomy 7 is reported. A 5-year-old boy presented with anemia, thrombocytopenia, and hepatosplenomegaly in whom erythroleukemia was diagnosed. Prolonged pancytopenia accompanied by persistent fever and huge splenomegaly and hepatomegaly became evident after 2 courses of chemotherapy. On bone marrow aspiration, macrophages phagocytosing erythroid precursors were observed and the diagnosis of HLH was established; additionally, monosomy 7 was detected on bone marrow cytogenetic examination. In conclusion, monosomy 7 can lead to erythrophagocytosis associated with erythroid leukemia and should be considered among the chromosomal abnormalities contributing to the association. |
| format | Article |
| id | doaj-art-a2952d444ffb47e6b34b301b76c33a09 |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-a2952d444ffb47e6b34b301b76c33a092025-08-20T02:20:55ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/581073581073Hemophagocytic Lymphohistiocytosis Complicating Erythroleukemia in a Child with Monosomy 7: A Case Report and Review of the LiteratureSamin Alavi0Maryam Ebadi1Alireza Jenabzadeh2M. T. Arzanian3Sh. Shamsian4Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Mofid Children’s Hospital, Tehran 15468-15514, IranTehran University of Medical Sciences, Tehran, IranPediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Mofid Children’s Hospital, Tehran 15468-15514, IranPediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Mofid Children’s Hospital, Tehran 15468-15514, IranPediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Mofid Children’s Hospital, Tehran 15468-15514, IranHerein, the first case of childhood erythrophagocytosis following chemotherapy for erythroleukemia in a child with monosomy 7 is reported. A 5-year-old boy presented with anemia, thrombocytopenia, and hepatosplenomegaly in whom erythroleukemia was diagnosed. Prolonged pancytopenia accompanied by persistent fever and huge splenomegaly and hepatomegaly became evident after 2 courses of chemotherapy. On bone marrow aspiration, macrophages phagocytosing erythroid precursors were observed and the diagnosis of HLH was established; additionally, monosomy 7 was detected on bone marrow cytogenetic examination. In conclusion, monosomy 7 can lead to erythrophagocytosis associated with erythroid leukemia and should be considered among the chromosomal abnormalities contributing to the association.http://dx.doi.org/10.1155/2013/581073 |
| spellingShingle | Samin Alavi Maryam Ebadi Alireza Jenabzadeh M. T. Arzanian Sh. Shamsian Hemophagocytic Lymphohistiocytosis Complicating Erythroleukemia in a Child with Monosomy 7: A Case Report and Review of the Literature Case Reports in Hematology |
| title | Hemophagocytic Lymphohistiocytosis Complicating Erythroleukemia in a Child with Monosomy 7: A Case Report and Review of the Literature |
| title_full | Hemophagocytic Lymphohistiocytosis Complicating Erythroleukemia in a Child with Monosomy 7: A Case Report and Review of the Literature |
| title_fullStr | Hemophagocytic Lymphohistiocytosis Complicating Erythroleukemia in a Child with Monosomy 7: A Case Report and Review of the Literature |
| title_full_unstemmed | Hemophagocytic Lymphohistiocytosis Complicating Erythroleukemia in a Child with Monosomy 7: A Case Report and Review of the Literature |
| title_short | Hemophagocytic Lymphohistiocytosis Complicating Erythroleukemia in a Child with Monosomy 7: A Case Report and Review of the Literature |
| title_sort | hemophagocytic lymphohistiocytosis complicating erythroleukemia in a child with monosomy 7 a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2013/581073 |
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