A narrative review of pediatric peripheral arterial aneurysms
Background: Pediatric peripheral arterial aneurysms are uncommon and their natural history and management protocols are not well-defined. Methods: This is a single-center retrospective review of medical records of pediatric peripheral arterial aneurysms along with their treatment, outcomes and genet...
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Elsevier
2025-01-01
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| Series: | JVS-Vascular Insights |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949912725000613 |
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| author | Yashashwini Sudina, MS Prajna B. Kota, MS, MCh Vijaya Tourani, MD Prem Chand Gupta, MS |
| author_facet | Yashashwini Sudina, MS Prajna B. Kota, MS, MCh Vijaya Tourani, MD Prem Chand Gupta, MS |
| author_sort | Yashashwini Sudina, MS |
| collection | DOAJ |
| description | Background: Pediatric peripheral arterial aneurysms are uncommon and their natural history and management protocols are not well-defined. Methods: This is a single-center retrospective review of medical records of pediatric peripheral arterial aneurysms along with their treatment, outcomes and genetic studies. We also performed a systematic review of the literature on pediatric arterial aneurysms. Results: From our records we identified five aneurysms in five children involving the radial, facial, subclavian, costocervical trunk, and axillary arteries. All aneurysms were treated surgically with good outcomes and genetic studies were abnormal in four of the five patients. Histopathology was nonspecific for any etiology and showed myxoid degeneration of the tunica media for all aneurysms. This systematic review included 147 articles from 6484 publications that were used for synthesis. We included 195 children with 321 aneurysms in this analysis. There was a male preponderance (63.4%) with mean age of 6.3 years (range 2 days to 18 years). Iliac artery was most frequently affected (26.8%), followed by brachial artery (19.3%). Nearly one-third had bilateral aneurysms and 43% had aneurysms at multiple sites. Concurrent visceral aneurysms, predominantly aortic, renal, and coronary were seen in 55 children (37.4%). The commonest etiology was idiopathic (41%) followed by Kawasaki disease (23.5%) and infection (7.2%). Genetic testing was done for 14 children, with 7 having a contributing genetic component. Treatment protocols included medical management, open surgery, endovascular intervention, hybrid repairs, and observation only. Conclusions: Pediatric arterial aneurysms can be treated surgically with good outcomes and may often be associated with genetic abnormalities. The approach to treatment is diverse, and it is difficult to recommend a standardized protocol. |
| format | Article |
| id | doaj-art-a294cd2c1e894c7bb9d7ab7ddc596461 |
| institution | Kabale University |
| issn | 2949-9127 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JVS-Vascular Insights |
| spelling | doaj-art-a294cd2c1e894c7bb9d7ab7ddc5964612025-08-20T03:44:57ZengElsevierJVS-Vascular Insights2949-91272025-01-01310024410.1016/j.jvsvi.2025.100244A narrative review of pediatric peripheral arterial aneurysmsYashashwini Sudina, MS0Prajna B. Kota, MS, MCh1Vijaya Tourani, MD2Prem Chand Gupta, MS3Vascular Division, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PADivision of Vascular and Thoracic Surgery, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, IndiaDepartment of Pathology, Care Hospitals, Hyderabad, IndiaDepartment of Vascular Surgery, Care Hospitals, Hyderabad, India; Correspondence: Prem Chand Gupta, MS, Clinical Director and Chief, Department of Vascular Surgery, Care Hospital, Road No 10, Banjara Hills, Hyderabad 500034, IndiaBackground: Pediatric peripheral arterial aneurysms are uncommon and their natural history and management protocols are not well-defined. Methods: This is a single-center retrospective review of medical records of pediatric peripheral arterial aneurysms along with their treatment, outcomes and genetic studies. We also performed a systematic review of the literature on pediatric arterial aneurysms. Results: From our records we identified five aneurysms in five children involving the radial, facial, subclavian, costocervical trunk, and axillary arteries. All aneurysms were treated surgically with good outcomes and genetic studies were abnormal in four of the five patients. Histopathology was nonspecific for any etiology and showed myxoid degeneration of the tunica media for all aneurysms. This systematic review included 147 articles from 6484 publications that were used for synthesis. We included 195 children with 321 aneurysms in this analysis. There was a male preponderance (63.4%) with mean age of 6.3 years (range 2 days to 18 years). Iliac artery was most frequently affected (26.8%), followed by brachial artery (19.3%). Nearly one-third had bilateral aneurysms and 43% had aneurysms at multiple sites. Concurrent visceral aneurysms, predominantly aortic, renal, and coronary were seen in 55 children (37.4%). The commonest etiology was idiopathic (41%) followed by Kawasaki disease (23.5%) and infection (7.2%). Genetic testing was done for 14 children, with 7 having a contributing genetic component. Treatment protocols included medical management, open surgery, endovascular intervention, hybrid repairs, and observation only. Conclusions: Pediatric arterial aneurysms can be treated surgically with good outcomes and may often be associated with genetic abnormalities. The approach to treatment is diverse, and it is difficult to recommend a standardized protocol.http://www.sciencedirect.com/science/article/pii/S2949912725000613Arterial aneurysmChildrenGenetic study |
| spellingShingle | Yashashwini Sudina, MS Prajna B. Kota, MS, MCh Vijaya Tourani, MD Prem Chand Gupta, MS A narrative review of pediatric peripheral arterial aneurysms JVS-Vascular Insights Arterial aneurysm Children Genetic study |
| title | A narrative review of pediatric peripheral arterial aneurysms |
| title_full | A narrative review of pediatric peripheral arterial aneurysms |
| title_fullStr | A narrative review of pediatric peripheral arterial aneurysms |
| title_full_unstemmed | A narrative review of pediatric peripheral arterial aneurysms |
| title_short | A narrative review of pediatric peripheral arterial aneurysms |
| title_sort | narrative review of pediatric peripheral arterial aneurysms |
| topic | Arterial aneurysm Children Genetic study |
| url | http://www.sciencedirect.com/science/article/pii/S2949912725000613 |
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