Assessment of IL-27 as a Predictive Biomarker for Immune Response in Asthmatic Patients in Diyala Governorate
Asthma is a persistent inflammatory respiratory disease characterized by coughing, wheezing, and intermittent dyspnea, as well as a sensation of chest tightness. The relationship between interleukin-27 (IL-27) and asthma is not precisely known yet. This study attempted to estimate the serum level...
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University of Thi-Qar
2025-06-01
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| Series: | مجلة علوم ذي قار |
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| Online Access: | https://jsci.utq.edu.iq/index.php/main/article/view/1368 |
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| author | Ahmed Salman Hind Jaber Ekhlas Saddam |
| author_facet | Ahmed Salman Hind Jaber Ekhlas Saddam |
| author_sort | Ahmed Salman |
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Asthma is a persistent inflammatory respiratory disease characterized by coughing, wheezing, and intermittent dyspnea, as well as a sensation of chest tightness. The relationship between interleukin-27 (IL-27) and asthma is not precisely known yet. This study attempted to estimate the serum level of IL-27 and its relationship with immunological and inflammatory markers in patients suffering from asthma. The demographic characteristics of this study were analyzed statistically. The serum levels of IL-27 were evaluated by Enzyme-linked immunosorbent assay (ELISA). CRP and Total IgE were evaluated by Cobas C111 and Cobas E411, respectively. The study showed a highly significant difference in IL-27, CRP, and total IgE when we compared between the patient group (62.12 ± 16.58 pg/ml, 11.2 ± 6.29 mg/l, and 297.26 ± 86.6 IU/ml), and the healthy control group (39.32 ± 3.576 pg/ml, 2.49 ± 1.1 mg/l, and 93 ± 18.3 IU/ml) respectively. ROC analysis of the studied biomarkers showed high sensitivity and specificity. That observation of elevation in all studied biomarker levels in asthma patients indicates a strong evidence in the diagnosis of asthma, as well as in the differentiation between acute and chronic cases, and in determining the severity of asthma.
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| format | Article |
| id | doaj-art-a293ff7ded8a402da69643d03d6384cf |
| institution | DOAJ |
| issn | 1991-8690 2709-0256 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | University of Thi-Qar |
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| series | مجلة علوم ذي قار |
| spelling | doaj-art-a293ff7ded8a402da69643d03d6384cf2025-08-20T03:13:07ZengUniversity of Thi-Qarمجلة علوم ذي قار1991-86902709-02562025-06-0112110.32792/utq/utjsci/v12i1.1368Assessment of IL-27 as a Predictive Biomarker for Immune Response in Asthmatic Patients in Diyala GovernorateAhmed Salman0Hind Jaber1Ekhlas Saddam2Department of Medical Laboratory Techniques, College of Health and Medical Techniques, Middle Technical UniversityDepartment of Medical Laboratory Techniques, College of Health and Medical Techniques, Middle Technical UniversityDepartment of Medical Laboratory Techniques, College of Health and Medical Techniques, Middle Technical University Asthma is a persistent inflammatory respiratory disease characterized by coughing, wheezing, and intermittent dyspnea, as well as a sensation of chest tightness. The relationship between interleukin-27 (IL-27) and asthma is not precisely known yet. This study attempted to estimate the serum level of IL-27 and its relationship with immunological and inflammatory markers in patients suffering from asthma. The demographic characteristics of this study were analyzed statistically. The serum levels of IL-27 were evaluated by Enzyme-linked immunosorbent assay (ELISA). CRP and Total IgE were evaluated by Cobas C111 and Cobas E411, respectively. The study showed a highly significant difference in IL-27, CRP, and total IgE when we compared between the patient group (62.12 ± 16.58 pg/ml, 11.2 ± 6.29 mg/l, and 297.26 ± 86.6 IU/ml), and the healthy control group (39.32 ± 3.576 pg/ml, 2.49 ± 1.1 mg/l, and 93 ± 18.3 IU/ml) respectively. ROC analysis of the studied biomarkers showed high sensitivity and specificity. That observation of elevation in all studied biomarker levels in asthma patients indicates a strong evidence in the diagnosis of asthma, as well as in the differentiation between acute and chronic cases, and in determining the severity of asthma. https://jsci.utq.edu.iq/index.php/main/article/view/1368AllergyAsthmaIL-27CRPTotal IgE |
| spellingShingle | Ahmed Salman Hind Jaber Ekhlas Saddam Assessment of IL-27 as a Predictive Biomarker for Immune Response in Asthmatic Patients in Diyala Governorate مجلة علوم ذي قار Allergy Asthma IL-27 CRP Total IgE |
| title | Assessment of IL-27 as a Predictive Biomarker for Immune Response in Asthmatic Patients in Diyala Governorate |
| title_full | Assessment of IL-27 as a Predictive Biomarker for Immune Response in Asthmatic Patients in Diyala Governorate |
| title_fullStr | Assessment of IL-27 as a Predictive Biomarker for Immune Response in Asthmatic Patients in Diyala Governorate |
| title_full_unstemmed | Assessment of IL-27 as a Predictive Biomarker for Immune Response in Asthmatic Patients in Diyala Governorate |
| title_short | Assessment of IL-27 as a Predictive Biomarker for Immune Response in Asthmatic Patients in Diyala Governorate |
| title_sort | assessment of il 27 as a predictive biomarker for immune response in asthmatic patients in diyala governorate |
| topic | Allergy Asthma IL-27 CRP Total IgE |
| url | https://jsci.utq.edu.iq/index.php/main/article/view/1368 |
| work_keys_str_mv | AT ahmedsalman assessmentofil27asapredictivebiomarkerforimmuneresponseinasthmaticpatientsindiyalagovernorate AT hindjaber assessmentofil27asapredictivebiomarkerforimmuneresponseinasthmaticpatientsindiyalagovernorate AT ekhlassaddam assessmentofil27asapredictivebiomarkerforimmuneresponseinasthmaticpatientsindiyalagovernorate |