Premenopausal Breast Cancer Risk Factors and Associations with Molecular Subtypes: A Case-Control Study
Background. Breast cancer (BC) is the most prevalent cancer in women and the leading cause of women’s cancer-related deaths and morbidity worldwide. In Rwanda, BC incidence is increasing with an unacceptably high mortality rate in premenopausal women. Objectives. The purpose was to identify modifiab...
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Wiley
2021-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2021/5560559 |
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| author | Faustin Ntirenganya Jean Damascene Twagirumukiza Georges Bucyibaruta Belson Rugwizangoga Stephen Rulisa |
| author_facet | Faustin Ntirenganya Jean Damascene Twagirumukiza Georges Bucyibaruta Belson Rugwizangoga Stephen Rulisa |
| author_sort | Faustin Ntirenganya |
| collection | DOAJ |
| description | Background. Breast cancer (BC) is the most prevalent cancer in women and the leading cause of women’s cancer-related deaths and morbidity worldwide. In Rwanda, BC incidence is increasing with an unacceptably high mortality rate in premenopausal women. Objectives. The purpose was to identify modifiable BC risk factors and assess associations between common breast cancer risks factors and molecular subtypes in premenopausal women in Rwanda. Methods. This was a case-control study. Premenopausal women with histological confirmation of BC and frequency-matched for age controls were recruited. A preestablished questionnaire was administered to both cases and controls for sociodemographics, BC probable risk factors, and clinical and pathological characteristics. BC was classified into luminal A, luminal B, HER2-type, basal-like (triple negative), and unclassified molecular subtypes by immunohistochemistry (IHC). Odds ratio (OR) and 95% confidence interval (CI) were estimated using multivariate logistic regression analysis. Results. 340 participants were recruited into the study (170 cases vs. 170 controls). The median age was 39 years. The majority of cases presented at advanced stages of the disease (51.2% in stages III and IV) and had invasive ductal carcinoma (98.2%). 60.6% had subtypes of poor prognosis (HER2 enriched 14.7%, triple negative 12.9%, and unclassified 32.9%). Alcohol intake AOR=3.73,95%CI 2.19−6.32,p<0.001, obesity/overweight in adolescence or early adulthood AOR=10.86,95%CI 4.82−24.4,p<0.001, history of primary infertility AOR=33.8,95%CI 3.5−321.5,p=0.002, nulliparity AOR=3.75,95%CI 1.61−8.75,p=0.002, and a history of benign breast disease AOR=6.06,95%CI 1.19−30.73,p=0.03 were associated with the occurrence of premenopausal breast cancer. There was no significant difference between risk factor stratification per molecular subtype. Conclusion. Several reproductive, environmental, and lifestyle risk factors have been identified to be associated with premenopausal BC. Among them, alcohol intake and obesity/overweight during adolescence/early adulthood can be modified. Interventions targeting alcohol consumption and obesity/overweight in adolescents and young adults may decrease the incidence of premenopausal breast cancer. |
| format | Article |
| id | doaj-art-a2927ea199064a7c96722dfb24d29f51 |
| institution | OA Journals |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-a2927ea199064a7c96722dfb24d29f512025-08-20T02:20:55ZengWileyInternational Journal of Breast Cancer2090-31702090-31892021-01-01202110.1155/2021/55605595560559Premenopausal Breast Cancer Risk Factors and Associations with Molecular Subtypes: A Case-Control StudyFaustin Ntirenganya0Jean Damascene Twagirumukiza1Georges Bucyibaruta2Belson Rugwizangoga3Stephen Rulisa4College of Medicine and Health Sciences, School of Medicine and Pharmacy, University of Rwanda, RwandaCollege of Medicine and Health Sciences, School of Public Health, University of Rwanda, RwandaBiostatistics, Spatio-Temporal Modeling of Infectious Diseases: Environment and Health Department, University of Waterloo, CanadaCollege of Medicine and Health Sciences, School of Medicine and Pharmacy, University of Rwanda, RwandaCollege of Medicine and Health Sciences, School of Medicine and Pharmacy, University of Rwanda, RwandaBackground. Breast cancer (BC) is the most prevalent cancer in women and the leading cause of women’s cancer-related deaths and morbidity worldwide. In Rwanda, BC incidence is increasing with an unacceptably high mortality rate in premenopausal women. Objectives. The purpose was to identify modifiable BC risk factors and assess associations between common breast cancer risks factors and molecular subtypes in premenopausal women in Rwanda. Methods. This was a case-control study. Premenopausal women with histological confirmation of BC and frequency-matched for age controls were recruited. A preestablished questionnaire was administered to both cases and controls for sociodemographics, BC probable risk factors, and clinical and pathological characteristics. BC was classified into luminal A, luminal B, HER2-type, basal-like (triple negative), and unclassified molecular subtypes by immunohistochemistry (IHC). Odds ratio (OR) and 95% confidence interval (CI) were estimated using multivariate logistic regression analysis. Results. 340 participants were recruited into the study (170 cases vs. 170 controls). The median age was 39 years. The majority of cases presented at advanced stages of the disease (51.2% in stages III and IV) and had invasive ductal carcinoma (98.2%). 60.6% had subtypes of poor prognosis (HER2 enriched 14.7%, triple negative 12.9%, and unclassified 32.9%). Alcohol intake AOR=3.73,95%CI 2.19−6.32,p<0.001, obesity/overweight in adolescence or early adulthood AOR=10.86,95%CI 4.82−24.4,p<0.001, history of primary infertility AOR=33.8,95%CI 3.5−321.5,p=0.002, nulliparity AOR=3.75,95%CI 1.61−8.75,p=0.002, and a history of benign breast disease AOR=6.06,95%CI 1.19−30.73,p=0.03 were associated with the occurrence of premenopausal breast cancer. There was no significant difference between risk factor stratification per molecular subtype. Conclusion. Several reproductive, environmental, and lifestyle risk factors have been identified to be associated with premenopausal BC. Among them, alcohol intake and obesity/overweight during adolescence/early adulthood can be modified. Interventions targeting alcohol consumption and obesity/overweight in adolescents and young adults may decrease the incidence of premenopausal breast cancer.http://dx.doi.org/10.1155/2021/5560559 |
| spellingShingle | Faustin Ntirenganya Jean Damascene Twagirumukiza Georges Bucyibaruta Belson Rugwizangoga Stephen Rulisa Premenopausal Breast Cancer Risk Factors and Associations with Molecular Subtypes: A Case-Control Study International Journal of Breast Cancer |
| title | Premenopausal Breast Cancer Risk Factors and Associations with Molecular Subtypes: A Case-Control Study |
| title_full | Premenopausal Breast Cancer Risk Factors and Associations with Molecular Subtypes: A Case-Control Study |
| title_fullStr | Premenopausal Breast Cancer Risk Factors and Associations with Molecular Subtypes: A Case-Control Study |
| title_full_unstemmed | Premenopausal Breast Cancer Risk Factors and Associations with Molecular Subtypes: A Case-Control Study |
| title_short | Premenopausal Breast Cancer Risk Factors and Associations with Molecular Subtypes: A Case-Control Study |
| title_sort | premenopausal breast cancer risk factors and associations with molecular subtypes a case control study |
| url | http://dx.doi.org/10.1155/2021/5560559 |
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