Chemical Composition, Antioxidant, and Enzyme Inhibitory Activities of <i>Artemisia schmidtiana</i> Maxim. Essential Oil
<i>Artemisia schmidtiana</i> Maxim., a plant belonging to the Asteraceae family, is renowned for its extensive ethnomedicinal applications and distinctive aromatic qualities. This study evaluated the chemical composition, antioxidant capacity, and inhibitory effects on acetylcholinestera...
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2025-05-01
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| author | Xinyu Zhu Xu Liu |
| author_facet | Xinyu Zhu Xu Liu |
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| description | <i>Artemisia schmidtiana</i> Maxim., a plant belonging to the Asteraceae family, is renowned for its extensive ethnomedicinal applications and distinctive aromatic qualities. This study evaluated the chemical composition, antioxidant capacity, and inhibitory effects on acetylcholinesterase (AChE), α-glucosidase, and β-lactamase of its essential oil (EO). The major constituents of the EO were identified as germacrene D (16.29%), falcarinol (11.02%), β-caryophyllene (9.43%), α-zingiberene (7.93%), phytol (6.06%), and α-humulene (4.04%). The EO demonstrated radical scavenging activity against DPPH (44.9% at 5 mg/mL) and ABTS (IC<sub>50</sub> = 0.72 ± 0.02 mg/mL) radicals, with a FRAP antioxidant capacity of 126.61 ± 0.59 μmol·g<sup>−1</sup>. Additionally, the EO exhibited modest AChE inhibition (16.7% at 250 μg/mL) and significant inhibition of α-glucosidase and β-lactamase, with IC<sub>50</sub> values of 178.80 ± 17.02 μg/mL and 40.06 ± 8.22 μg/mL, respectively. Molecular docking revealed favorable interactions between the major EO compounds and the tested enzymes, providing a theoretical foundation for future drug development. These findings suggest that <i>A. schmidtiana</i> EO holds potential for applications in the food and pharmaceutical industries, warranting further investigation. |
| format | Article |
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| institution | DOAJ |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-a29126406e284d02b9e2a2add8e8976a2025-08-20T03:14:32ZengMDPI AGBiomolecules2218-273X2025-05-0115573610.3390/biom15050736Chemical Composition, Antioxidant, and Enzyme Inhibitory Activities of <i>Artemisia schmidtiana</i> Maxim. Essential OilXinyu Zhu0Xu Liu1SDU-ANU Joint Science College, Shandong University, Weihai 264209, ChinaMarine College, Shandong University, Weihai 264209, China<i>Artemisia schmidtiana</i> Maxim., a plant belonging to the Asteraceae family, is renowned for its extensive ethnomedicinal applications and distinctive aromatic qualities. This study evaluated the chemical composition, antioxidant capacity, and inhibitory effects on acetylcholinesterase (AChE), α-glucosidase, and β-lactamase of its essential oil (EO). The major constituents of the EO were identified as germacrene D (16.29%), falcarinol (11.02%), β-caryophyllene (9.43%), α-zingiberene (7.93%), phytol (6.06%), and α-humulene (4.04%). The EO demonstrated radical scavenging activity against DPPH (44.9% at 5 mg/mL) and ABTS (IC<sub>50</sub> = 0.72 ± 0.02 mg/mL) radicals, with a FRAP antioxidant capacity of 126.61 ± 0.59 μmol·g<sup>−1</sup>. Additionally, the EO exhibited modest AChE inhibition (16.7% at 250 μg/mL) and significant inhibition of α-glucosidase and β-lactamase, with IC<sub>50</sub> values of 178.80 ± 17.02 μg/mL and 40.06 ± 8.22 μg/mL, respectively. Molecular docking revealed favorable interactions between the major EO compounds and the tested enzymes, providing a theoretical foundation for future drug development. These findings suggest that <i>A. schmidtiana</i> EO holds potential for applications in the food and pharmaceutical industries, warranting further investigation.https://www.mdpi.com/2218-273X/15/5/736<i>Artemisia schmidtiana</i> Maxim.essential oilchemical compositionbiological activitymolecular docking |
| spellingShingle | Xinyu Zhu Xu Liu Chemical Composition, Antioxidant, and Enzyme Inhibitory Activities of <i>Artemisia schmidtiana</i> Maxim. Essential Oil Biomolecules <i>Artemisia schmidtiana</i> Maxim. essential oil chemical composition biological activity molecular docking |
| title | Chemical Composition, Antioxidant, and Enzyme Inhibitory Activities of <i>Artemisia schmidtiana</i> Maxim. Essential Oil |
| title_full | Chemical Composition, Antioxidant, and Enzyme Inhibitory Activities of <i>Artemisia schmidtiana</i> Maxim. Essential Oil |
| title_fullStr | Chemical Composition, Antioxidant, and Enzyme Inhibitory Activities of <i>Artemisia schmidtiana</i> Maxim. Essential Oil |
| title_full_unstemmed | Chemical Composition, Antioxidant, and Enzyme Inhibitory Activities of <i>Artemisia schmidtiana</i> Maxim. Essential Oil |
| title_short | Chemical Composition, Antioxidant, and Enzyme Inhibitory Activities of <i>Artemisia schmidtiana</i> Maxim. Essential Oil |
| title_sort | chemical composition antioxidant and enzyme inhibitory activities of i artemisia schmidtiana i maxim essential oil |
| topic | <i>Artemisia schmidtiana</i> Maxim. essential oil chemical composition biological activity molecular docking |
| url | https://www.mdpi.com/2218-273X/15/5/736 |
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