From Traditional Amazon Use to Food Applications: <i>Tapirira guianensis</i> Seed Extracts as a Triad of Antiproliferative Effect, Oxidative Defense, and Antimalarial Activity
<i>Tapirira guianensis</i> is a tropical plant found in South America and is widely used by indigenous communities owing to its medicinal properties. Its seeds are rich in phenolic compounds that are known for their anti-inflammatory, antioxidant, and antimicrobial properties. Despite it...
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MDPI AG
2025-02-01
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| author | Marcell Crispim Thaise Caputo Silva Amanda dos Santos Lima Laura da Silva Cruz Nathalia Alves Bento Thiago Mendanha Cruz Yasmin Stelle Josiana Moreira Mar Daniel de Queiroz Rocha Jaqueline de Araújo Bezerra Luciana Azevedo |
| author_facet | Marcell Crispim Thaise Caputo Silva Amanda dos Santos Lima Laura da Silva Cruz Nathalia Alves Bento Thiago Mendanha Cruz Yasmin Stelle Josiana Moreira Mar Daniel de Queiroz Rocha Jaqueline de Araújo Bezerra Luciana Azevedo |
| author_sort | Marcell Crispim |
| collection | DOAJ |
| description | <i>Tapirira guianensis</i> is a tropical plant found in South America and is widely used by indigenous communities owing to its medicinal properties. Its seeds are rich in phenolic compounds that are known for their anti-inflammatory, antioxidant, and antimicrobial properties. Despite its traditional use, there are limited scientific data on the biological activities of its seed extracts, especially in the context of antimalarial and cytoprotective effects. In this study, we investigated the chemical composition, antioxidant potential, cytotoxic effects, and antimalarial properties of hydroethanolic, ethanolic, and aqueous seed extracts. A 1:1 (<i>v</i>/<i>v</i>) water/ethanol combination efficiently extracted bioactive compounds and delivered the highest phenolic compound content. Furthermore, the hydroethanolic extracts exhibited significant biological activities, including an ability to reduce cancer-cell viability, protect against damage caused by reactive oxygen species (ROS), and decrease chromosomal aberrations, while exhibiting high efficacy against both chloroquine-sensitive and chloroquine-resistant <i>Plasmodium falciparum</i> strains. Hence, the use of <i>T. guianensis</i> seed extract as a natural source of bioactive compounds with cytoprotective, antiproliferative, antioxidant, and antimalarial properties is innovative and highlights the need for additional in vivo studies to better elucidate its mechanisms of action and safety. |
| format | Article |
| id | doaj-art-a286d4e0cd7c4a0fac910baad2744b86 |
| institution | OA Journals |
| issn | 2304-8158 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Foods |
| spelling | doaj-art-a286d4e0cd7c4a0fac910baad2744b862025-08-20T02:12:25ZengMDPI AGFoods2304-81582025-02-0114346710.3390/foods14030467From Traditional Amazon Use to Food Applications: <i>Tapirira guianensis</i> Seed Extracts as a Triad of Antiproliferative Effect, Oxidative Defense, and Antimalarial ActivityMarcell Crispim0Thaise Caputo Silva1Amanda dos Santos Lima2Laura da Silva Cruz3Nathalia Alves Bento4Thiago Mendanha Cruz5Yasmin Stelle6Josiana Moreira Mar7Daniel de Queiroz Rocha8Jaqueline de Araújo Bezerra9Luciana Azevedo10Nutritional and Toxicological Analysis Laboratory In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37130-000, MG, BrazilNutritional and Toxicological Analysis Laboratory In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37130-000, MG, BrazilNutritional and Toxicological Analysis Laboratory In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37130-000, MG, BrazilNutritional and Toxicological Analysis Laboratory In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37130-000, MG, BrazilNutritional and Toxicological Analysis Laboratory In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37130-000, MG, BrazilDepartment of Chemistry, State University of Ponta Grossa (UEPG), Ponta Grossa 84030-900, PR, BrazilDepartment of Chemistry, State University of Ponta Grossa (UEPG), Ponta Grossa 84030-900, PR, BrazilDepartment of Chemistry, Environment, and Food, Federal Institute of Education, Science and Technology of Amazonas, Manaus 69020-120, AM, BrazilDepartment of Chemistry, Environment, and Food, Federal Institute of Education, Science and Technology of Amazonas, Manaus 69020-120, AM, BrazilDepartment of Chemistry, Environment, and Food, Federal Institute of Education, Science and Technology of Amazonas, Manaus 69020-120, AM, BrazilNutritional and Toxicological Analysis Laboratory In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37130-000, MG, Brazil<i>Tapirira guianensis</i> is a tropical plant found in South America and is widely used by indigenous communities owing to its medicinal properties. Its seeds are rich in phenolic compounds that are known for their anti-inflammatory, antioxidant, and antimicrobial properties. Despite its traditional use, there are limited scientific data on the biological activities of its seed extracts, especially in the context of antimalarial and cytoprotective effects. In this study, we investigated the chemical composition, antioxidant potential, cytotoxic effects, and antimalarial properties of hydroethanolic, ethanolic, and aqueous seed extracts. A 1:1 (<i>v</i>/<i>v</i>) water/ethanol combination efficiently extracted bioactive compounds and delivered the highest phenolic compound content. Furthermore, the hydroethanolic extracts exhibited significant biological activities, including an ability to reduce cancer-cell viability, protect against damage caused by reactive oxygen species (ROS), and decrease chromosomal aberrations, while exhibiting high efficacy against both chloroquine-sensitive and chloroquine-resistant <i>Plasmodium falciparum</i> strains. Hence, the use of <i>T. guianensis</i> seed extract as a natural source of bioactive compounds with cytoprotective, antiproliferative, antioxidant, and antimalarial properties is innovative and highlights the need for additional in vivo studies to better elucidate its mechanisms of action and safety.https://www.mdpi.com/2304-8158/14/3/467erythrocytesantioxidantsby-product<i>Plasmodium falciparum</i> |
| spellingShingle | Marcell Crispim Thaise Caputo Silva Amanda dos Santos Lima Laura da Silva Cruz Nathalia Alves Bento Thiago Mendanha Cruz Yasmin Stelle Josiana Moreira Mar Daniel de Queiroz Rocha Jaqueline de Araújo Bezerra Luciana Azevedo From Traditional Amazon Use to Food Applications: <i>Tapirira guianensis</i> Seed Extracts as a Triad of Antiproliferative Effect, Oxidative Defense, and Antimalarial Activity Foods erythrocytes antioxidants by-product <i>Plasmodium falciparum</i> |
| title | From Traditional Amazon Use to Food Applications: <i>Tapirira guianensis</i> Seed Extracts as a Triad of Antiproliferative Effect, Oxidative Defense, and Antimalarial Activity |
| title_full | From Traditional Amazon Use to Food Applications: <i>Tapirira guianensis</i> Seed Extracts as a Triad of Antiproliferative Effect, Oxidative Defense, and Antimalarial Activity |
| title_fullStr | From Traditional Amazon Use to Food Applications: <i>Tapirira guianensis</i> Seed Extracts as a Triad of Antiproliferative Effect, Oxidative Defense, and Antimalarial Activity |
| title_full_unstemmed | From Traditional Amazon Use to Food Applications: <i>Tapirira guianensis</i> Seed Extracts as a Triad of Antiproliferative Effect, Oxidative Defense, and Antimalarial Activity |
| title_short | From Traditional Amazon Use to Food Applications: <i>Tapirira guianensis</i> Seed Extracts as a Triad of Antiproliferative Effect, Oxidative Defense, and Antimalarial Activity |
| title_sort | from traditional amazon use to food applications i tapirira guianensis i seed extracts as a triad of antiproliferative effect oxidative defense and antimalarial activity |
| topic | erythrocytes antioxidants by-product <i>Plasmodium falciparum</i> |
| url | https://www.mdpi.com/2304-8158/14/3/467 |
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