Studying HLA class I polymorphism in brain tumour patients
The present study aimed at shed light on the association between HLA-class I antigens (A, B and Cw) and brain tumours (meningioma and glioma) in the basis of their individual frequencies or two-locus association A total of 52 brain tumour patients were enrolled in this study, with an age range of...
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University of Baghdad, College of Science for Women
2012-09-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/1387 |
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| description | The present study aimed at shed light on the association between HLA-class I antigens (A, B and Cw) and brain tumours (meningioma and glioma) in the basis of their individual frequencies or two-locus association A total of 52 brain tumour patients were enrolled in this study, with an age range of 7-68 years. The patients were divided into two clinical groups; meningioma (20 cases) and glioma (22 cases), while the remaining 10 cases represented other types of brain tumour. Control samples included 47 Iraqi Arab apparently healthy blood volunteers, with an age range of 15-50 year. Three HLA antigens showed a significant increased frequency in total patients as compared to controls. They were B13 (34.6 vs. 6.5%), B40 (15.4 vs. 2.2%) and Cw3 (15.4 vs. 2.2%). In contrast, B5 was significantly decreased (15.4 vs. 34.8%). In meningioma patients, only B13 was significantly increased (35.0 vs. 6.5%), while in glioma patients, B13 (36.4 vs. 6.5%) and Cw5 (36.4 vs. 2.2%) were significantly increased. Variations between patients and controls have been also encountered for the observed and expected HLA-two locus associations (B13-Cw3, B13-Cw5 and B40-Cw5). |
| format | Article |
| id | doaj-art-a281168881304869b6f687cae2fdfb46 |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2012-09-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-a281168881304869b6f687cae2fdfb462025-08-20T03:56:59ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862012-09-019310.21123/bsj.9.3.481-490Studying HLA class I polymorphism in brain tumour patientsBaghdad Science JournalThe present study aimed at shed light on the association between HLA-class I antigens (A, B and Cw) and brain tumours (meningioma and glioma) in the basis of their individual frequencies or two-locus association A total of 52 brain tumour patients were enrolled in this study, with an age range of 7-68 years. The patients were divided into two clinical groups; meningioma (20 cases) and glioma (22 cases), while the remaining 10 cases represented other types of brain tumour. Control samples included 47 Iraqi Arab apparently healthy blood volunteers, with an age range of 15-50 year. Three HLA antigens showed a significant increased frequency in total patients as compared to controls. They were B13 (34.6 vs. 6.5%), B40 (15.4 vs. 2.2%) and Cw3 (15.4 vs. 2.2%). In contrast, B5 was significantly decreased (15.4 vs. 34.8%). In meningioma patients, only B13 was significantly increased (35.0 vs. 6.5%), while in glioma patients, B13 (36.4 vs. 6.5%) and Cw5 (36.4 vs. 2.2%) were significantly increased. Variations between patients and controls have been also encountered for the observed and expected HLA-two locus associations (B13-Cw3, B13-Cw5 and B40-Cw5).http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/1387" Brain tumour, HLA-class I, Two locus associations" |
| spellingShingle | Baghdad Science Journal Studying HLA class I polymorphism in brain tumour patients مجلة بغداد للعلوم " Brain tumour, HLA-class I, Two locus associations" |
| title | Studying HLA class I polymorphism in brain tumour patients |
| title_full | Studying HLA class I polymorphism in brain tumour patients |
| title_fullStr | Studying HLA class I polymorphism in brain tumour patients |
| title_full_unstemmed | Studying HLA class I polymorphism in brain tumour patients |
| title_short | Studying HLA class I polymorphism in brain tumour patients |
| title_sort | studying hla class i polymorphism in brain tumour patients |
| topic | " Brain tumour, HLA-class I, Two locus associations" |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/1387 |
| work_keys_str_mv | AT baghdadsciencejournal studyinghlaclassipolymorphisminbraintumourpatients |