Assessment of histology's performance compared with PCR in the diagnosis of Helicobacter pylori infection
Aim: Histology is the most widely used test to detect H. pylori. PCR is less used but allows the detection of both infection and antibiotics' resistance. Methods: We conducted a monocentric cross-sectional study, collecting 97 symptomatic patients to assess the diagnostic performance of histolo...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Future Science OA |
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| Online Access: | https://www.tandfonline.com/doi/10.2144/fsoa-2023-0217 |
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| author | Manel Moalla Lassaad Chtourou Basma Mnif Slim Charfi Hend Smaoui Mon Boudabous Leila Mnif Ali Amouri Hela Gdoura Adnene Hammami Tahya Boudawara Nabil Tahri |
| author_facet | Manel Moalla Lassaad Chtourou Basma Mnif Slim Charfi Hend Smaoui Mon Boudabous Leila Mnif Ali Amouri Hela Gdoura Adnene Hammami Tahya Boudawara Nabil Tahri |
| author_sort | Manel Moalla |
| collection | DOAJ |
| description | Aim: Histology is the most widely used test to detect H. pylori. PCR is less used but allows the detection of both infection and antibiotics' resistance. Methods: We conducted a monocentric cross-sectional study, collecting 97 symptomatic patients to assess the diagnostic performance of histology in the detection of H. pylori infection compared with PCR. Results: Sensitivity of histology in comparison with PCR was 81.5% and specificity was 56.3%. A history of anti-H. pylori therapy intake, as well as the density of the bacterium on the gastric sample and the presence of gastric atrophy, were significantly correlated to the PCR's result in terms of H. pylori detection. Conclusion: Thus, histology can be considered as an efficient test compared with PCR in H. pylori detection. |
| format | Article |
| id | doaj-art-a271eee4d1d84fcb8ead2262dc4c315d |
| institution | DOAJ |
| issn | 2056-5623 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-a271eee4d1d84fcb8ead2262dc4c315d2025-08-20T02:41:39ZengTaylor & Francis GroupFuture Science OA2056-56232024-12-0110110.2144/fsoa-2023-0217Assessment of histology's performance compared with PCR in the diagnosis of Helicobacter pylori infectionManel Moalla0Lassaad Chtourou1Basma Mnif2Slim Charfi3Hend Smaoui4Mon Boudabous5Leila Mnif6Ali Amouri7Hela Gdoura8Adnene Hammami9Tahya Boudawara10Nabil Tahri11Gastroenterology department, Hedi Chaker hospital, Sfax, TunisiaGastroenterology department, Hedi Chaker hospital, Sfax, TunisiaMicrobiology department, Habib Bourguiba hospital, Sfax, TunisiaPathology department, Habib Bourguiba hospital, Sfax, TunisiaGastroenterology department, Hedi Chaker hospital, Sfax, TunisiaGastroenterology department, Hedi Chaker hospital, Sfax, TunisiaGastroenterology department, Hedi Chaker hospital, Sfax, TunisiaGastroenterology department, Hedi Chaker hospital, Sfax, TunisiaGastroenterology department, Hedi Chaker hospital, Sfax, TunisiaMicrobiology department, Habib Bourguiba hospital, Sfax, TunisiaPathology department, Habib Bourguiba hospital, Sfax, TunisiaGastroenterology department, Hedi Chaker hospital, Sfax, TunisiaAim: Histology is the most widely used test to detect H. pylori. PCR is less used but allows the detection of both infection and antibiotics' resistance. Methods: We conducted a monocentric cross-sectional study, collecting 97 symptomatic patients to assess the diagnostic performance of histology in the detection of H. pylori infection compared with PCR. Results: Sensitivity of histology in comparison with PCR was 81.5% and specificity was 56.3%. A history of anti-H. pylori therapy intake, as well as the density of the bacterium on the gastric sample and the presence of gastric atrophy, were significantly correlated to the PCR's result in terms of H. pylori detection. Conclusion: Thus, histology can be considered as an efficient test compared with PCR in H. pylori detection.https://www.tandfonline.com/doi/10.2144/fsoa-2023-0217diagnostic methodsHelicobacter pylorihistologypathologyPCR |
| spellingShingle | Manel Moalla Lassaad Chtourou Basma Mnif Slim Charfi Hend Smaoui Mon Boudabous Leila Mnif Ali Amouri Hela Gdoura Adnene Hammami Tahya Boudawara Nabil Tahri Assessment of histology's performance compared with PCR in the diagnosis of Helicobacter pylori infection Future Science OA diagnostic methods Helicobacter pylori histology pathology PCR |
| title | Assessment of histology's performance compared with PCR in the diagnosis of Helicobacter pylori infection |
| title_full | Assessment of histology's performance compared with PCR in the diagnosis of Helicobacter pylori infection |
| title_fullStr | Assessment of histology's performance compared with PCR in the diagnosis of Helicobacter pylori infection |
| title_full_unstemmed | Assessment of histology's performance compared with PCR in the diagnosis of Helicobacter pylori infection |
| title_short | Assessment of histology's performance compared with PCR in the diagnosis of Helicobacter pylori infection |
| title_sort | assessment of histology s performance compared with pcr in the diagnosis of helicobacter pylori infection |
| topic | diagnostic methods Helicobacter pylori histology pathology PCR |
| url | https://www.tandfonline.com/doi/10.2144/fsoa-2023-0217 |
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