Undeveloped Region in Target-Strategies and Potential in Antiviral Drug Discovery
Drug resistance is a looming threat to global health security, undermining the effectiveness of current treatments and increasing treatment failures. To address this challenge, it is necessary to explore innovative strategies by identifying new binding mechanisms and targeting previously undeveloped...
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2025-03-01
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| Series: | Pharmaceutical Fronts |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-2523-2174 |
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| _version_ | 1849393191915094016 |
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| author | Shaoqing Du Xinyong Liu Xueping Hu Peng Zhan |
| author_facet | Shaoqing Du Xinyong Liu Xueping Hu Peng Zhan |
| author_sort | Shaoqing Du |
| collection | DOAJ |
| description | Drug resistance is a looming threat to global health security, undermining the effectiveness of current treatments and increasing treatment failures. To address this challenge, it is necessary to explore innovative strategies by identifying new binding mechanisms and targeting previously undeveloped therapeutic avenues. This paper reviewed the potential of leveraging undeveloped domains to combat drug resistance and proposes a range of methodologies to accurately identify those specific targets. There is also an extensive review of the challenges associated with targeting undeveloped areas and strategies to effectively address them. In this process, the application of artificial intelligence (AI) can effectively improve the efficiency of drug design, while appropriate attention should be paid to the physicochemical and drug-like properties of pharmaceutical compounds in the realm of drug discovery. Given the above, focusing on these undeveloped areas could provide a promising pathway to address drug resistance; however, achieving this objective necessitates sustained investigative efforts and inventive approaches. |
| format | Article |
| id | doaj-art-a26d5ba266014cdb9af856c8fd35a5e8 |
| institution | Kabale University |
| issn | 2628-5088 2628-5096 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Pharmaceutical Fronts |
| spelling | doaj-art-a26d5ba266014cdb9af856c8fd35a5e82025-08-20T03:40:30ZengGeorg Thieme Verlag KGPharmaceutical Fronts2628-50882628-50962025-03-010701e1e810.1055/a-2523-2174Undeveloped Region in Target-Strategies and Potential in Antiviral Drug DiscoveryShaoqing Du0Xinyong Liu1Xueping Hu2Peng Zhan3Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of ChinaDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of ChinaInstitute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao, People's Republic of ChinaDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of ChinaDrug resistance is a looming threat to global health security, undermining the effectiveness of current treatments and increasing treatment failures. To address this challenge, it is necessary to explore innovative strategies by identifying new binding mechanisms and targeting previously undeveloped therapeutic avenues. This paper reviewed the potential of leveraging undeveloped domains to combat drug resistance and proposes a range of methodologies to accurately identify those specific targets. There is also an extensive review of the challenges associated with targeting undeveloped areas and strategies to effectively address them. In this process, the application of artificial intelligence (AI) can effectively improve the efficiency of drug design, while appropriate attention should be paid to the physicochemical and drug-like properties of pharmaceutical compounds in the realm of drug discovery. Given the above, focusing on these undeveloped areas could provide a promising pathway to address drug resistance; however, achieving this objective necessitates sustained investigative efforts and inventive approaches.http://www.thieme-connect.de/DOI/DOI?10.1055/a-2523-2174drug resistancetargeting undeveloped sitesantiviral drug designtarget-based drug discovery |
| spellingShingle | Shaoqing Du Xinyong Liu Xueping Hu Peng Zhan Undeveloped Region in Target-Strategies and Potential in Antiviral Drug Discovery Pharmaceutical Fronts drug resistance targeting undeveloped sites antiviral drug design target-based drug discovery |
| title | Undeveloped Region in Target-Strategies and Potential in Antiviral Drug Discovery |
| title_full | Undeveloped Region in Target-Strategies and Potential in Antiviral Drug Discovery |
| title_fullStr | Undeveloped Region in Target-Strategies and Potential in Antiviral Drug Discovery |
| title_full_unstemmed | Undeveloped Region in Target-Strategies and Potential in Antiviral Drug Discovery |
| title_short | Undeveloped Region in Target-Strategies and Potential in Antiviral Drug Discovery |
| title_sort | undeveloped region in target strategies and potential in antiviral drug discovery |
| topic | drug resistance targeting undeveloped sites antiviral drug design target-based drug discovery |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-2523-2174 |
| work_keys_str_mv | AT shaoqingdu undevelopedregionintargetstrategiesandpotentialinantiviraldrugdiscovery AT xinyongliu undevelopedregionintargetstrategiesandpotentialinantiviraldrugdiscovery AT xuepinghu undevelopedregionintargetstrategiesandpotentialinantiviraldrugdiscovery AT pengzhan undevelopedregionintargetstrategiesandpotentialinantiviraldrugdiscovery |