Opioid System and Epithelial–Mesenchymal Transition
Opioids are a challenging class of drugs due to their dual role. They alleviate pain, but also pose a risk of dependency, or trigger constipation, particularly in cancer patients, who require the more potent painkillers in more advanced stages of the disease, closely linked to pain resulting from ge...
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MDPI AG
2025-01-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/18/1/120 |
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| author | Marzena Łazarczyk Dominik Skiba Michel-Edwar Mickael Kinga Jaskuła Agata Nawrocka Piotr Religa Mariusz Sacharczuk |
| author_facet | Marzena Łazarczyk Dominik Skiba Michel-Edwar Mickael Kinga Jaskuła Agata Nawrocka Piotr Religa Mariusz Sacharczuk |
| author_sort | Marzena Łazarczyk |
| collection | DOAJ |
| description | Opioids are a challenging class of drugs due to their dual role. They alleviate pain, but also pose a risk of dependency, or trigger constipation, particularly in cancer patients, who require the more potent painkillers in more advanced stages of the disease, closely linked to pain resulting from general inflammation, bone metastases, and primary or secondary tumour outgrowth-related nerve damage. Clinicians’ vigilance considering treatment with opioids is necessary, bearing in mind extensive data accumulated over decades that have reported the contribution of opioids to immunosuppression, tumour progression, or impaired tissue regeneration, either following opioid use during surgical tumour resection and post-surgical pain treatment, or as a result of other diseases like diabetes, where chronic wounds healing constitutes a challenge. During last few years, an increasing trend for seeking relationships between opioids and epithelial–mesenchymal transition (EMT) in cancer research can be observed. Transiently lasting EMT is desirable during wound healing, but in cancer, or vital organ fibrogenesis, EMT appears to be an obstacle to overcome, forcing to adjust treatment strategies that would reduce the risk for worsening of the disease outcome and patient prognosis. The same opioid may demonstrate promoting or inhibitory effect on EMT, dependently on various conditions in particular clinical cases. We have summarized current findings on this issue to uncover some rules that govern opioid-mediated EMT induction or repression; however, many aspects still remain to be elucidated. |
| format | Article |
| id | doaj-art-a26b896e151640e995018394c7c4b6dc |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-a26b896e151640e995018394c7c4b6dc2025-01-24T13:45:28ZengMDPI AGPharmaceuticals1424-82472025-01-0118112010.3390/ph18010120Opioid System and Epithelial–Mesenchymal TransitionMarzena Łazarczyk0Dominik Skiba1Michel-Edwar Mickael2Kinga Jaskuła3Agata Nawrocka4Piotr Religa5Mariusz Sacharczuk6Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postepu 36A, 05-552 Jastrzebiec, PolandDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postepu 36A, 05-552 Jastrzebiec, PolandDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postepu 36A, 05-552 Jastrzebiec, PolandDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postepu 36A, 05-552 Jastrzebiec, PolandDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postepu 36A, 05-552 Jastrzebiec, PolandDepartment of Medicine, Karolinska Institute, 171 77 Solna, SwedenDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postepu 36A, 05-552 Jastrzebiec, PolandOpioids are a challenging class of drugs due to their dual role. They alleviate pain, but also pose a risk of dependency, or trigger constipation, particularly in cancer patients, who require the more potent painkillers in more advanced stages of the disease, closely linked to pain resulting from general inflammation, bone metastases, and primary or secondary tumour outgrowth-related nerve damage. Clinicians’ vigilance considering treatment with opioids is necessary, bearing in mind extensive data accumulated over decades that have reported the contribution of opioids to immunosuppression, tumour progression, or impaired tissue regeneration, either following opioid use during surgical tumour resection and post-surgical pain treatment, or as a result of other diseases like diabetes, where chronic wounds healing constitutes a challenge. During last few years, an increasing trend for seeking relationships between opioids and epithelial–mesenchymal transition (EMT) in cancer research can be observed. Transiently lasting EMT is desirable during wound healing, but in cancer, or vital organ fibrogenesis, EMT appears to be an obstacle to overcome, forcing to adjust treatment strategies that would reduce the risk for worsening of the disease outcome and patient prognosis. The same opioid may demonstrate promoting or inhibitory effect on EMT, dependently on various conditions in particular clinical cases. We have summarized current findings on this issue to uncover some rules that govern opioid-mediated EMT induction or repression; however, many aspects still remain to be elucidated.https://www.mdpi.com/1424-8247/18/1/120epithelial to mesenchymal transitionopioidE-cadherinN-cadherinvimentin |
| spellingShingle | Marzena Łazarczyk Dominik Skiba Michel-Edwar Mickael Kinga Jaskuła Agata Nawrocka Piotr Religa Mariusz Sacharczuk Opioid System and Epithelial–Mesenchymal Transition Pharmaceuticals epithelial to mesenchymal transition opioid E-cadherin N-cadherin vimentin |
| title | Opioid System and Epithelial–Mesenchymal Transition |
| title_full | Opioid System and Epithelial–Mesenchymal Transition |
| title_fullStr | Opioid System and Epithelial–Mesenchymal Transition |
| title_full_unstemmed | Opioid System and Epithelial–Mesenchymal Transition |
| title_short | Opioid System and Epithelial–Mesenchymal Transition |
| title_sort | opioid system and epithelial mesenchymal transition |
| topic | epithelial to mesenchymal transition opioid E-cadherin N-cadherin vimentin |
| url | https://www.mdpi.com/1424-8247/18/1/120 |
| work_keys_str_mv | AT marzenałazarczyk opioidsystemandepithelialmesenchymaltransition AT dominikskiba opioidsystemandepithelialmesenchymaltransition AT micheledwarmickael opioidsystemandepithelialmesenchymaltransition AT kingajaskuła opioidsystemandepithelialmesenchymaltransition AT agatanawrocka opioidsystemandepithelialmesenchymaltransition AT piotrreliga opioidsystemandepithelialmesenchymaltransition AT mariuszsacharczuk opioidsystemandepithelialmesenchymaltransition |