POSITRON EMISION TOMOGRAPHY FOR DETECTION OF DISTANT METASTASES IN PATIENTS WITH BREAST CANCER
Background. Standard imaging techniques, including chest x-ray, ultrasonography, magnetic resonance imaging and computed tomography have some limitations in terms of their ability to detect distant metastases.The purpose of the study was to search for additional diagnostic techniques for breast canc...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2020-03-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/1327 |
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| author | N. G. Chanchikova E. A. Karlova A. S. Savelyeva O. A. Silkina V. I. Chernov R. V. Zelchan I. G. Sinilkin O. D. Bragina A. A. Medvedeva |
| author_facet | N. G. Chanchikova E. A. Karlova A. S. Savelyeva O. A. Silkina V. I. Chernov R. V. Zelchan I. G. Sinilkin O. D. Bragina A. A. Medvedeva |
| author_sort | N. G. Chanchikova |
| collection | DOAJ |
| description | Background. Standard imaging techniques, including chest x-ray, ultrasonography, magnetic resonance imaging and computed tomography have some limitations in terms of their ability to detect distant metastases.The purpose of the study was to search for additional diagnostic techniques for breast cancer detection. Material and methods. Results of 18F-FDG PET/scans were retrospectively analyzed in 50 breast cancer patients. Results. Traditional imaging techniques showed suspicion for distant metastases in 29 patients. Of them, metastatic disease was histologically confirmed in 16 patients. Sensitivity and specificity of traditional imaging techniques were 80 % and 67.5 %, respectively. Distant metastases were not detected by 18F-FDG PET/CT in 29 patients, however in one of these patients, both CT and cytological examination performed during the follow-up period revealed pleural metastases. 18F-FDG PET/CT detected distant metastases in 21 patients. Of these patients, two had no evidence of metastases confirmed by biopsy and other diagnostic imaging methods as well as during follow-up period. The sensitivity and specificity of 18F-FDG PET/CT in detection of distant metastases were 95 % and 93.3 %, respectively.Conclusion. Sensitivity of 18F-FDG PET/CT in the detection of breast cancer distant metastasis was significantly higher than that of the traditional imaging techniques. |
| format | Article |
| id | doaj-art-a26b3f268b704f3ba097018f28ef267a |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2020-03-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-a26b3f268b704f3ba097018f28ef267a2025-08-20T02:59:08ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682020-03-01191909610.21294/1814-4861-2020-19-1-90-96715POSITRON EMISION TOMOGRAPHY FOR DETECTION OF DISTANT METASTASES IN PATIENTS WITH BREAST CANCERN. G. Chanchikova0E. A. Karlova1A. S. Savelyeva2O. A. Silkina3V. I. Chernov4R. V. Zelchan5I. G. Sinilkin6O. D. Bragina7A. A. Medvedeva8Center of Nuclear MedicineCenter of Nuclear MedicineCenter of Nuclear MedicineCenter of Nuclear MedicineCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, National Research Tomsk Polytechnic UniversityNuclear Medicine Department, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesBackground. Standard imaging techniques, including chest x-ray, ultrasonography, magnetic resonance imaging and computed tomography have some limitations in terms of their ability to detect distant metastases.The purpose of the study was to search for additional diagnostic techniques for breast cancer detection. Material and methods. Results of 18F-FDG PET/scans were retrospectively analyzed in 50 breast cancer patients. Results. Traditional imaging techniques showed suspicion for distant metastases in 29 patients. Of them, metastatic disease was histologically confirmed in 16 patients. Sensitivity and specificity of traditional imaging techniques were 80 % and 67.5 %, respectively. Distant metastases were not detected by 18F-FDG PET/CT in 29 patients, however in one of these patients, both CT and cytological examination performed during the follow-up period revealed pleural metastases. 18F-FDG PET/CT detected distant metastases in 21 patients. Of these patients, two had no evidence of metastases confirmed by biopsy and other diagnostic imaging methods as well as during follow-up period. The sensitivity and specificity of 18F-FDG PET/CT in detection of distant metastases were 95 % and 93.3 %, respectively.Conclusion. Sensitivity of 18F-FDG PET/CT in the detection of breast cancer distant metastasis was significantly higher than that of the traditional imaging techniques.https://www.siboncoj.ru/jour/article/view/1327positron emision tomographypet/ct18f-fdgdistant metastasesbreast cancer |
| spellingShingle | N. G. Chanchikova E. A. Karlova A. S. Savelyeva O. A. Silkina V. I. Chernov R. V. Zelchan I. G. Sinilkin O. D. Bragina A. A. Medvedeva POSITRON EMISION TOMOGRAPHY FOR DETECTION OF DISTANT METASTASES IN PATIENTS WITH BREAST CANCER Сибирский онкологический журнал positron emision tomography pet/ct 18f-fdg distant metastases breast cancer |
| title | POSITRON EMISION TOMOGRAPHY FOR DETECTION OF DISTANT METASTASES IN PATIENTS WITH BREAST CANCER |
| title_full | POSITRON EMISION TOMOGRAPHY FOR DETECTION OF DISTANT METASTASES IN PATIENTS WITH BREAST CANCER |
| title_fullStr | POSITRON EMISION TOMOGRAPHY FOR DETECTION OF DISTANT METASTASES IN PATIENTS WITH BREAST CANCER |
| title_full_unstemmed | POSITRON EMISION TOMOGRAPHY FOR DETECTION OF DISTANT METASTASES IN PATIENTS WITH BREAST CANCER |
| title_short | POSITRON EMISION TOMOGRAPHY FOR DETECTION OF DISTANT METASTASES IN PATIENTS WITH BREAST CANCER |
| title_sort | positron emision tomography for detection of distant metastases in patients with breast cancer |
| topic | positron emision tomography pet/ct 18f-fdg distant metastases breast cancer |
| url | https://www.siboncoj.ru/jour/article/view/1327 |
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